Frontotemporal Dementia, Progressive Supranuclear Palsy, Healthy Subjects
Conditions
Brief summary
Frontal patients are impaired in categorisation and analogical reasoning tasks, and different functional imaging studies from our group have shown the involvement of the prefrontal cortex in categorisation and analogy tasks. The aim of this project is to test our hypotheses about the role of the prefrontal cortex in explicit and implicit categorisation and analogy tasks.
Interventions
DEVICEtranscranial magnetic stimulation
OTHERMRI imaging
OTHEREEG recording
BEHAVIORALNeuropsychological examination
Sponsors
Fondation pour la Recherche Médicale
Institut National de la Santé Et de la Recherche Médicale, France
Study design
Allocation
NON_RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
20 Years to 85 Years
Healthy volunteers
Yes
Inclusion criteria
Healthy subjects: * subject affiliated to national health insurance * informed consent signed * normal neurological examination * subject aged at least 20 Patients: * FTD or PSP diagnostic criteria filled * patient affiliated to national health insurance * informed consent signed
Exclusion criteria
* Severe psychiatric symptomatology and psychotropic drug use * unability to understand or perform the cognitive tasks.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Performance in the implicat task | day of inclusion (one day) | Reaction time and accuracy will be registered for this categorization task. This task will be used in patients with FTD and in healthy controls (n=60). Participants will come only once during one day ot the research centre. |
| Performance in the Similitude task | from inclusion to 4 months after inclusion | Reaction time and accuracy will be recorded while healthy subjects perform this categorization task, after a session of rTMS or during on line TMS (n=40). Participants will come 3 to 5 times at the research centre in a maximum period of 4 months. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| recording of EEG | day of inclusion (one day) | EEG will be recorded in patients with FTD and in healthy controls for an analysis of event related potentials. Participants will come only once during one day a the research centre. |
| Analysis of MRI | day of inclusion (one day) | T1 MRI will be recorded for VBM analysis in patients with FTD and healthy controls. Participants will come only once during one day at the research centre |
Countries
France
Outcome results
None listed