Environmental Conditions, In Vitro Fertilisation
Conditions
Keywords
in vitro fertilisation, environmental conditions, pregnancy, live birth rate
Brief summary
The main purpose of the study is to assess the impact of environmental conditions on live-birth rates after intraconjugal IVF. The second purposes are * to assess the impact on pregnancies (prematurity, preeclampsia); * to assess the impact on newborn's health (stunted growth); * to evaluate the consistency of results observed between assisted pregnancies and spontaneous pregnancies.
Detailed description
This multicenter epidemiological study aims to analyze the individual standardized clinical records, collected prospectively since 2008 in the medically assisted procreation centers (MAP). These individual data will be mapped to the environmental data (meteorological and air quality), recorded in the area of residence of the mother at the time of conception and pregnancy, as well as to the socio-economic data. Choice of centers: * The study will be proposed to the 106 private or public centers in metropolitan France who are authorized for MAP procedures such as IVF and ICSI. * Only the centers who perform more than 200 oocyte retrievals per year will be selected to participate in the study. More than 80% of attempts performed by the selected centers should be available (without missing data) on the induced pregnancies and their outcome (minimum data set for each case: age of man and woman, cause of infertility, technique used, sperm collection method (ejaculation, surgical sperm retrieval techniques), total number of embryos obtained, clinical pregnancy or not, term of pregnancy, weight and height of the child at birth).
Interventions
None listed
Sponsors
UPRES EA 2506 (Santé-Environnement-Vieillissement), France
Assistance Publique - Hôpitaux de Paris
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Intraconjugal IVF and ICSI * Transfers of frozen embryos after intraconjugal IVF or ICSI
Exclusion criteria
* IVF and ICSI with sperm donation * IVF and ICSI with egg donation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Live birth rate | 1 year | Live birth rate after intraconjugal IVF (IVF and ICSI) by oocyte retrieval and by embryo transfer. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Fertilization rate | 1 year | Rate of fertilization (IVF and ICSI), rate of good quality embryos, rate of blastoformation (if prolonged culture), rate of embryo freezing. |
| Rates of clinical pregnancy | 1 year | Rates of assisted pregnancy, rate of spontaneous miscarriage, rate of medical termination of pregnancy, rate of pathology of pregnancy (pre-eclampsia, gestational diabetes, placenta praevia, signs of preterm labor with hospitalization). |
| Fetal growth restriction rate | 1 year | Fetal growth restriction rate, biometrics of child at birth (height, weight, head circumference, Body Mass Index), preterm birth rate, transfer rate to intensive care units. |
| Effect sizes and periods of susceptibility to environmental conditions | 5 years | Effect sizes and periods of susceptibility to environmental conditions among assisted pregnancies and spontaneous pregnancies. |
Countries
France
Contacts
Primary ContactAlain BEAUCHET, MD
Backup ContactPhilippe AEGERTER, MD, PhD
Outcome results
None listed