Aging, Memory Disorders, Mild Cognitive Impairment
Conditions
Keywords
Dementia, Prevention, Physical Activity
Brief summary
The principal aim of this study is to verify whether a program of supervised, multimodal physical exercise improves cognitive function and/or reduces the rate of cognitive decline in older adults
Detailed description
Community-dwelling volunteers, recruited from social centers, were invited to an in-person assessment that included a medical history questionnaire and examination, anthropometric measurements, blood tests for cardiovascular risk, and several outcome measures. Participants meeting the inclusion criteria were divided in 3 groups (participants without subjective or objective cognitive impairment, with subjective memory complaints and with mild cognitive impairments) and randomly assigned (1:1) to an experimental group or a control group, using a list of random numbers generated by a statistical software. The list was kept in a sealed envelope and a researcher, not directly involved in the recruitment and in the evaluation of the participants, assigned the allocation numbers.
Interventions
BEHAVIORALIntervention group
Supervised, multimodal physical activity including aerobic, resistance and stretching exercises
BEHAVIORALControl group
Usual physical activity, generally consisting in long walks and/or stretching, toning and/or balance exercises, or posture education
Sponsors
University of Molise
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
50 Years to 90 Years
Healthy volunteers
Yes
Inclusion criteria
Age \> 50 years old
Exclusion criteria
* Medical conditions that compromise survival or limit physical activity * Geriatric Depression Scale-15 score of 6 or higher * Alcohol intake \> 4 units/day * Mini- Mental State Examination \< 24 * Clinical Dementia Rating score of 1 or more
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change of Mini Mental State Examination (MMSE) score from baseline to 48 months | Baseline and every 6-12 months, over an intervention period of 48 months | Scale for grading cognitive function |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change of neuropsychological test battery from baseline to 48 months | Baseline and every 6 -12 months, over an intervention period of 48 months | It includes: Frontal Assessment Battery, Rey's Auditory Verbal Learning Test, Prose Memory, Stroop Color Word Interference Test, Attentive Matrices, Raven's Progressive Matrices, Trial Making Test, designs copying with and without programming models. |
| Change of Geriatric Depression Scale (GDS) from baseline to 48 months | Baseline and every 6 -12 months, over an intervention period of 48 months | A self-report assessment for identifing depression in the elderly |
| Change of Short-form Health Survey (SF-36) from baseline to 48 months | Baseline and every 6 -12 months, over an intervention period of 48 months | Assessment of health status |
| Change of Physical Activity Scale for the Elderly (PASE) from baseline to 48 months | Baseline and every 6 -12 months, over an intervention period of 48 months | Assessment of physical activity level in elderly |
| Change of AAHPERD (American Alliance for Health, Physical Education, Recreation and Dance) fitness test battery from baseline to 48 months | Baseline and every 6 -12 months, over an intervention period of 48 months | Functional fitness assessment |
| Change of Memory Complaint Questionnaire (MAC-Q) from baseline to 48 months | Baseline and every 6 -12 months, over an intervention period of 48 months | Assessment of subjective memory complaint |
Other
| Measure | Time frame | Description |
|---|---|---|
| Change of Composite cognitive score (CCS) from baseline to 48 months | Baseline and every 6 -12 months, over an intervention period of 48 months | It is calculated by averaging the standardized scores (Z-score) of all neuropsychological tests, for assessing the overall changes in cognitive performance. |
Countries
Italy
Outcome results
None listed