The Impact of Riboflavin on the Severity and Duration of Sports Related Concussion

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02235337

Enrollment

248

Registered

2014-09-09

Start date

2014-09-30

Completion date

2015-08-31

Last updated

2017-08-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sports Related Concussion

Keywords

Concussion, Sports related concussion, mTBI, Vitamin B, Riboflavin

Brief summary

The purpose of this study is to investigate the effectiveness of riboflavin to decrease the duration of time for a student-athlete to return to participation in sports after a sports related concussion.

Interventions

DRUGRiboflavin 400mg daily

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* All UVa and JMU student-athletes over the age of 18 years old who are diagnosed with a sports related concussion

Exclusion criteria

* Less than 18 years old * Greater than 24 hours have elapsed since the concussion occurred. * The student-athlete has already participated in the study during which he/she took Riboflavin * Non-sports related concussion not incurred while participating in the sport or training for the sport. As an example, a student-athlete who sustains a concussion as a result of a motor vehicle accident will be excluded from the study for that concussion

Design outcomes

Primary

Measure	Time frame
Time to return to full participation in sports after a sports related concussion	21 days or less

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026