Use of Gadolinium in CT Pulmonary Angiography

Efficacy of Gadolinium Contrast in CT Pulmonary Angiography in Patients With Allergy to Iodine

Status

Withdrawn

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02234375

Enrollment

Registered

2014-09-09

Start date

2017-07-31

Completion date

2019-12-31

Last updated

2020-02-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pulmonary Embolism

Keywords

Pulmonary embolism, Contrast, Computed tomography, Gadolinium

Brief summary

The study will investigate patients with clinical suspicion for pulmonary embolism (PE) who have a contraindication to iodine based contrast. These patients normally get investigated with studies such as ultrasound and nuclear medicine studies but the fastest and preferred investigation is CT with contrast to look for filling defects in the pulmonary arteries. The investigators will assess whether gadolinium, which is currently used with MRI can be used with CT as an alternative effective contrast in diagnosis or exclusion of PE. A new type of CT scanner, a Dual Energy Scanner will be used to improve the visibility of Gadolinium contrast on CT.

Detailed description

Contrast enhancement with Gadolinium will be evaluated to assess its efficacy for diagnosis and exclusion of pulmonary embolism in a patient who previously would not have been investigated with CTPA due to an underlying allergy to contrast or other contraindication. If this proves beneficial, it will allow such patients to be investigated successfully with CTPA

Interventions

DRUGGadolinium

agents will be administered intravenously and a CT scan will be performed to evaluate contrast enhancement characteristics of the agents to assess their feasibility as an alternative to Iodine based contrast agents

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

DIAGNOSTIC

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

20 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patients suspected of having a Pulmonary embolus * Allergy to Iodine based intravenous contrast

Exclusion criteria

* Renal impairment * Less than 20 years of age * Non-English speaking * Pregnancy * Allergy to Gadolinium

Design outcomes

Primary

Measure	Time frame	Description
Diagnosis of Pulmonary Embolism	24 hours	Ability of Gadolinium to diagnose pulmonary embolism on a dual energy CT scan

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026