Cocaine Use Disorder
Conditions
Keywords
cocaine, phendimetrazine, pharmacotherapy
Brief summary
This study will determine the safety and tolerability of phendimetrazine (Bontril®) as a pharmacotherapy for cocaine use disorder. A rigorous, inpatient human laboratory study will be conducted in which the subjective and physiological effects of cocaine are evaluated during maintenance on placebo and phendimetrazine.
Interventions
DRUGCocaine
The pharmacodynamic effects of cocaine will be determined during maintenance on placebo and phendimetrazine.
DRUGPlacebo
The pharmacodynamic effects of placebo will be determined during maintenance on placebo and phendimetrazine.
Sponsors
National Institute on Drug Abuse (NIDA)
William Stoops
Study design
Allocation
NON_RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
TRIPLE (Subject, Caregiver, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 55 Years
Healthy volunteers
Yes
Inclusion criteria
* Recent cocaine use
Exclusion criteria
* Abnormal screening outcome (e.g., ECG, blood chemistry result) that study physicians deem clinically significant * Current or past histories of substance abuse or dependence that are deemed by the study physicians to interfere with study completion * History of serious physical disease, current physical disease, impaired cardiovascular functioning, chronic obstructive pulmonary disease, history of seizure or current or past histories of serious psychiatric disorder that in the opinion of the study physician would interfere with study participation will be excluded from participation * Females not currently using effective birth control * Contraindications to cocaine or phendimetrazine
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Peak Systolic Pressure | This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions. | Systolic blood pressure was measured with an automated monitor. Higher values represent greater systolic pressure. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo maintenance conditions. |
| Peak Diastolic Pressure | This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions. | Diastolic blood pressure was measured with an automated monitor. Higher values represent greater diastolic pressure. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo maintenance conditions. |
| Peak Heart Rate | This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions. | Heart rate was measured with an automated monitor. Higher values represent greater heart rate. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo maintenance conditions. |
| Peak Temperature | This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions. | Oral temperature was measured with an automated monitor. Higher values represent greater temperature. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo maintenance conditions. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Peak Ratings of Bad Effect on the Visual Analog Scale | This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions. | Subjects rated their feelings of Bad Effect on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions. |
| Peak Ratings of Euphoric on the Visual Analog Scale | This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions. | Subjects rated their feelings of Euphoric on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions. |
| Peak Ratings of Good Effect on the Visual Analog Scale | This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions. | Subjects rated their feelings of Good Effect on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions. |
| Peak Ratings of High on the Visual Analog Scale | This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions. | Subjects rated their feelings of High on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions. |
| Peak Ratings of Irregular/Racing Heartbeat on the Visual Analog Scale | This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions. | Subjects rated their feelings of Irregular/Racing Heartbeat on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions. |
| Peak Ratings of Like Drug on the Visual Analog Scale | This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions. | Subjects rated their feelings of Like Drug on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions. |
| Peak Ratings of Nauseated/Queasy/Sick to Stomach on the Visual Analog Scale | This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions. | Subjects rated their feelings of Nauseated/Queasy/Sick to Stomach on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions. |
| Peak Ratings of Nervous/Anxious on the Visual Analog Scale | This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions. | Subjects rated their feelings of Nervous/Anxious on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions. |
| Peak Ratings of Willing to Pay For on the Visual Analog Scale | This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions. | Subjects rated their feelings of Willing to Pay For on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions. |
| Peak Score on Sedative Subscale of the Adjective Rating Scale | This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions. | Subjects completed 16 items that loaded into the Sedative Subscale of the Adjective Rating Scale. The items were rated 0-4 on a Likert-type scale and the sum for the 16 sedative items was summed to yield the Sedative Subscale score. The maximum score for this scale was 64, the minimum was 0. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions. |
| Peak Ratings of Performance Improved on the Visual Analog Scale | This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions. | Subjects rated their feelings of Performance Improved on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions. |
| Peak Ratings of Restless on the Visual Analog Scale | This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions. | Subjects rated their feelings of Restless on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions. |
| Peak Ratings of Rush on the Visual Analog Scale | This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions. | Subjects rated their feelings of Rush on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions. |
| Peak Ratings of Shaky/Jittery on the Visual Analog Scale | This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions. | Subjects rated their feelings of Shaky/Jittery on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions. |
| Peak Ratings of Sluggish/Fatigued/Lazy on the Visual Analog Scale | This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions. | Subjects rated their feelings of Sluggish/Fatigued/Lazy on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions. |
| Peak Ratings of Stimulated on the Visual Analog Scale | This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions. | Subjects rated their feelings of Stimulated on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions. |
| Peak Ratings of Willing to Take Again on the Visual Analog Scale | This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions. | Subjects rated their feelings of Willing to Take Again on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions. |
| Peak Ratings of Talkative/Friendly on the Visual Analog Scale | This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions. | Subjects rated their feelings of Talkative/Friendly on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions. |
| Peak Ratings of Performance Impaired on the Visual Analog Scale | This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions. | Subjects rated their feelings of Performance Impaired on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions. |
| Peak Score on Stimulant Subscale of the Adjective Rating Scale | This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions. | Subjects completed 16 items that loaded into the Stimulant Subscale of the Adjective Rating Scale. The items were rated 0-4 on a Likert-type scale and the sum for the 16 stimulant items was summed to yield the Stimulant Subscale score. The maximum score for this scale was 64, the minimum was 0. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions. |
| Peak Ratings of Active, Alert, Energetic on the Visual Analog Scale | This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions. | Subjects rated their feelings of Active, Alert, Energetic on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions. |
| Peak Ratings of Any Effect on the Visual Analog Scale | This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions. | Subjects rated their feelings of Any Effect on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions. |
Countries
United States
Participant flow
Pre-assignment details
Eleven subjects were enrolled (i.e., signed consent), but only 10 subjects completed. Due to the within-subject nature of this study (i.e., missing data from the 11th subject cannot be analyzed with repeated-measures ANOVA), only data from the 10 subjects who completed the protocol were analyzed and reported.
Participants by arm
| Arm | Count |
|---|---|
| Phendimetrazine Dose Escalation Subjects were maintained on oral placebo, 70 mg phendimetrazine/day, 140 mg phendimetrazine/day and 210 mg phendimetrazine/day in ascending order.
Cocaine was administered acutely after at least seven days of maintenance on each condition.
Placebo cocaine was administered acutely after at least seven days of maintenance on each condition.
Cocaine: The pharmacodynamic effects of cocaine were determined during maintenance on placebo and phendimetrazine.
Placebo: The pharmacodynamic effects of placebo cocaine were determined during maintenance on placebo and phendimetrazine. | 10 |
| Total | 10 |
Withdrawals & dropouts
| Period | Reason | FG000 |
|---|---|---|
| Overall Study | Adverse Event | 1 |
Baseline characteristics
| Characteristic | Phendimetrazine Dose Escalation |
|---|---|
| Age, Continuous | 43 years STANDARD_DEVIATION 4 |
| Ethnicity (NIH/OMB) Hispanic or Latino | 1 Participants |
| Ethnicity (NIH/OMB) Not Hispanic or Latino | 9 Participants |
| Ethnicity (NIH/OMB) Unknown or Not Reported | 0 Participants |
| Race (NIH/OMB) American Indian or Alaska Native | 0 Participants |
| Race (NIH/OMB) Asian | 0 Participants |
| Race (NIH/OMB) Black or African American | 6 Participants |
| Race (NIH/OMB) More than one race | 0 Participants |
| Race (NIH/OMB) Native Hawaiian or Other Pacific Islander | 0 Participants |
| Race (NIH/OMB) Unknown or Not Reported | 0 Participants |
| Race (NIH/OMB) White | 4 Participants |
| Region of Enrollment United States | 10 participants |
| Sex: Female, Male Female | 1 Participants |
| Sex: Female, Male Male | 9 Participants |
Adverse events
| Event type | EG000 affected / at risk |
|---|---|
| deaths Total, all-cause mortality | — / — |
| other Total, other adverse events | 1 / 11 |
| serious Total, serious adverse events | 0 / 11 |
Outcome results
Primary
Peak Diastolic Pressure
Diastolic blood pressure was measured with an automated monitor. Higher values represent greater diastolic pressure. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo maintenance conditions.
Time frame: This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Phendimetrazine Dose Escalation | Peak Diastolic Pressure | 0 mg Cocaine with 0 mg Phendimetrazine | 75.6 mm Hg | Standard Error 1.28 |
| Phendimetrazine Dose Escalation | Peak Diastolic Pressure | 10 mg Cocaine with 0 mg Phendimetrazine | 75.2 mm Hg | Standard Error 1.63 |
| Phendimetrazine Dose Escalation | Peak Diastolic Pressure | 20 mg Cocaine with 0 mg Phendimetrazine | 78.4 mm Hg | Standard Error 1.88 |
| Phendimetrazine Dose Escalation | Peak Diastolic Pressure | 40 mg Cocaine with 0 mg Phendimetrazine | 78 mm Hg | Standard Error 1.38 |
| Phendimetrazine Dose Escalation | Peak Diastolic Pressure | 80 mg Cocaine with 0 mg Phendimetrazine | 80.8 mm Hg | Standard Error 1.87 |
| Phendimetrazine Dose Escalation | Peak Diastolic Pressure | 0 mg Cocaine with 70 mg Phendimetrazine | 77.2 mm Hg | Standard Error 2.7 |
| Phendimetrazine Dose Escalation | Peak Diastolic Pressure | 10 mg Cocaine with 70 mg Phendimetrazine | 76.7 mm Hg | Standard Error 2.62 |
| Phendimetrazine Dose Escalation | Peak Diastolic Pressure | 20 mg Cocaine with 70 mg Phendimetrazine | 75.6 mm Hg | Standard Error 2.45 |
| Phendimetrazine Dose Escalation | Peak Diastolic Pressure | 40 mg Cocaine with 70 mg Phendimetrazine | 75.6 mm Hg | Standard Error 3.02 |
| Phendimetrazine Dose Escalation | Peak Diastolic Pressure | 80 mg Cocaine with 70 mg Phendimetrazine | 83.2 mm Hg | Standard Error 2.69 |
| Phendimetrazine Dose Escalation | Peak Diastolic Pressure | 0 mg Cocaine with 140 mg Phendimetrazine | 74.3 mm Hg | Standard Error 1.72 |
| Phendimetrazine Dose Escalation | Peak Diastolic Pressure | 10 mg Cocaine with 140 mg Phendimetrazine | 76 mm Hg | Standard Error 1.84 |
| Phendimetrazine Dose Escalation | Peak Diastolic Pressure | 20 mg Cocaine with 140 mg Phendimetrazine | 78.1 mm Hg | Standard Error 1.29 |
| Phendimetrazine Dose Escalation | Peak Diastolic Pressure | 40 mg Cocaine with 140 mg Phendimetrazine | 77.7 mm Hg | Standard Error 2.28 |
| Phendimetrazine Dose Escalation | Peak Diastolic Pressure | 80 mg Cocaine with 140 mg Phendimetrazine | 83.6 mm Hg | Standard Error 1.26 |
| Phendimetrazine Dose Escalation | Peak Diastolic Pressure | 0 mg Cocaine with 210 mg Phendimetrazine | 76.6 mm Hg | Standard Error 2.42 |
| Phendimetrazine Dose Escalation | Peak Diastolic Pressure | 10 mg Cocaine with 210 mg Phendimetrazine | 77.9 mm Hg | Standard Error 1.99 |
| Phendimetrazine Dose Escalation | Peak Diastolic Pressure | 20 mg Cocaine with 210 mg Phendimetrazine | 80.7 mm Hg | Standard Error 2.34 |
| Phendimetrazine Dose Escalation | Peak Diastolic Pressure | 40 mg Cocaine with 210 mg Phendimetrazine | 78.6 mm Hg | Standard Error 1.83 |
| Phendimetrazine Dose Escalation | Peak Diastolic Pressure | 80 mg Cocaine with 210 mg Phendimetrazine | 84.8 mm Hg | Standard Error 2.37 |
Primary
Peak Heart Rate
Heart rate was measured with an automated monitor. Higher values represent greater heart rate. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo maintenance conditions.
Time frame: This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Phendimetrazine Dose Escalation | Peak Heart Rate | 0 mg Cocaine with 0 mg Phendimetrazine | 75 Beats per Minute | Standard Error 3.72 |
| Phendimetrazine Dose Escalation | Peak Heart Rate | 10 mg Cocaine with 0 mg Phendimetrazine | 72.7 Beats per Minute | Standard Error 2.64 |
| Phendimetrazine Dose Escalation | Peak Heart Rate | 20 mg Cocaine with 0 mg Phendimetrazine | 77.4 Beats per Minute | Standard Error 4.19 |
| Phendimetrazine Dose Escalation | Peak Heart Rate | 40 mg Cocaine with 0 mg Phendimetrazine | 79.2 Beats per Minute | Standard Error 4.63 |
| Phendimetrazine Dose Escalation | Peak Heart Rate | 80 mg Cocaine with 0 mg Phendimetrazine | 87.8 Beats per Minute | Standard Error 5.6 |
| Phendimetrazine Dose Escalation | Peak Heart Rate | 0 mg Cocaine with 70 mg Phendimetrazine | 76.6 Beats per Minute | Standard Error 2.57 |
| Phendimetrazine Dose Escalation | Peak Heart Rate | 10 mg Cocaine with 70 mg Phendimetrazine | 75.3 Beats per Minute | Standard Error 3.21 |
| Phendimetrazine Dose Escalation | Peak Heart Rate | 20 mg Cocaine with 70 mg Phendimetrazine | 77 Beats per Minute | Standard Error 3.06 |
| Phendimetrazine Dose Escalation | Peak Heart Rate | 40 mg Cocaine with 70 mg Phendimetrazine | 81 Beats per Minute | Standard Error 4.48 |
| Phendimetrazine Dose Escalation | Peak Heart Rate | 80 mg Cocaine with 70 mg Phendimetrazine | 83.8 Beats per Minute | Standard Error 3.92 |
| Phendimetrazine Dose Escalation | Peak Heart Rate | 0 mg Cocaine with 140 mg Phendimetrazine | 82.1 Beats per Minute | Standard Error 4.07 |
| Phendimetrazine Dose Escalation | Peak Heart Rate | 10 mg Cocaine with 140 mg Phendimetrazine | 81.1 Beats per Minute | Standard Error 3.87 |
| Phendimetrazine Dose Escalation | Peak Heart Rate | 20 mg Cocaine with 140 mg Phendimetrazine | 83.4 Beats per Minute | Standard Error 4.81 |
| Phendimetrazine Dose Escalation | Peak Heart Rate | 40 mg Cocaine with 140 mg Phendimetrazine | 83.5 Beats per Minute | Standard Error 3.66 |
| Phendimetrazine Dose Escalation | Peak Heart Rate | 80 mg Cocaine with 140 mg Phendimetrazine | 84.8 Beats per Minute | Standard Error 4.03 |
| Phendimetrazine Dose Escalation | Peak Heart Rate | 0 mg Cocaine with 210 mg Phendimetrazine | 84.9 Beats per Minute | Standard Error 2.28 |
| Phendimetrazine Dose Escalation | Peak Heart Rate | 10 mg Cocaine with 210 mg Phendimetrazine | 77.5 Beats per Minute | Standard Error 2.2 |
| Phendimetrazine Dose Escalation | Peak Heart Rate | 20 mg Cocaine with 210 mg Phendimetrazine | 85.3 Beats per Minute | Standard Error 4.05 |
| Phendimetrazine Dose Escalation | Peak Heart Rate | 40 mg Cocaine with 210 mg Phendimetrazine | 82.8 Beats per Minute | Standard Error 3.08 |
| Phendimetrazine Dose Escalation | Peak Heart Rate | 80 mg Cocaine with 210 mg Phendimetrazine | 88.9 Beats per Minute | Standard Error 4.13 |
Primary
Peak Systolic Pressure
Systolic blood pressure was measured with an automated monitor. Higher values represent greater systolic pressure. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo maintenance conditions.
Time frame: This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Phendimetrazine Dose Escalation | Peak Systolic Pressure | 0 mg Cocaine with 0 mg Phendimetrazine | 115.4 mm Hg | Standard Error 2.54 |
| Phendimetrazine Dose Escalation | Peak Systolic Pressure | 10 mg Cocaine with 0 mg Phendimetrazine | 121.3 mm Hg | Standard Error 3.51 |
| Phendimetrazine Dose Escalation | Peak Systolic Pressure | 20 mg Cocaine with 0 mg Phendimetrazine | 123.4 mm Hg | Standard Error 4.06 |
| Phendimetrazine Dose Escalation | Peak Systolic Pressure | 40 mg Cocaine with 0 mg Phendimetrazine | 122.1 mm Hg | Standard Error 2.86 |
| Phendimetrazine Dose Escalation | Peak Systolic Pressure | 80 mg Cocaine with 0 mg Phendimetrazine | 135.4 mm Hg | Standard Error 3.89 |
| Phendimetrazine Dose Escalation | Peak Systolic Pressure | 0 mg Cocaine with 70 mg Phendimetrazine | 120.0 mm Hg | Standard Error 7.14 |
| Phendimetrazine Dose Escalation | Peak Systolic Pressure | 10 mg Cocaine with 70 mg Phendimetrazine | 119.7 mm Hg | Standard Error 3.54 |
| Phendimetrazine Dose Escalation | Peak Systolic Pressure | 20 mg Cocaine with 70 mg Phendimetrazine | 119.9 mm Hg | Standard Error 3.8 |
| Phendimetrazine Dose Escalation | Peak Systolic Pressure | 40 mg Cocaine with 70 mg Phendimetrazine | 125.4 mm Hg | Standard Error 6.05 |
| Phendimetrazine Dose Escalation | Peak Systolic Pressure | 80 mg Cocaine with 70 mg Phendimetrazine | 130.3 mm Hg | Standard Error 2.9 |
| Phendimetrazine Dose Escalation | Peak Systolic Pressure | 0 mg Cocaine with 140 mg Phendimetrazine | 117.9 mm Hg | Standard Error 4.78 |
| Phendimetrazine Dose Escalation | Peak Systolic Pressure | 10 mg Cocaine with 140 mg Phendimetrazine | 121.7 mm Hg | Standard Error 4.73 |
| Phendimetrazine Dose Escalation | Peak Systolic Pressure | 20 mg Cocaine with 140 mg Phendimetrazine | 122.1 mm Hg | Standard Error 4.4 |
| Phendimetrazine Dose Escalation | Peak Systolic Pressure | 40 mg Cocaine with 140 mg Phendimetrazine | 121.5 mm Hg | Standard Error 4.51 |
| Phendimetrazine Dose Escalation | Peak Systolic Pressure | 80 mg Cocaine with 140 mg Phendimetrazine | 131.9 mm Hg | Standard Error 3.6 |
| Phendimetrazine Dose Escalation | Peak Systolic Pressure | 0 mg Cocaine with 210 mg Phendimetrazine | 119.2 mm Hg | Standard Error 3.45 |
| Phendimetrazine Dose Escalation | Peak Systolic Pressure | 10 mg Cocaine with 210 mg Phendimetrazine | 119.7 mm Hg | Standard Error 4.09 |
| Phendimetrazine Dose Escalation | Peak Systolic Pressure | 20 mg Cocaine with 210 mg Phendimetrazine | 119.8 mm Hg | Standard Error 2.65 |
| Phendimetrazine Dose Escalation | Peak Systolic Pressure | 40 mg Cocaine with 210 mg Phendimetrazine | 119.3 mm Hg | Standard Error 2.72 |
| Phendimetrazine Dose Escalation | Peak Systolic Pressure | 80 mg Cocaine with 210 mg Phendimetrazine | 130.9 mm Hg | Standard Error 2.95 |
Primary
Peak Temperature
Oral temperature was measured with an automated monitor. Higher values represent greater temperature. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo maintenance conditions.
Time frame: This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Phendimetrazine Dose Escalation | Peak Temperature | 0 mg Cocaine with 0 mg Phendimetrazine | 98.09 Degrees Fahrenheit | Standard Error 0.13 |
| Phendimetrazine Dose Escalation | Peak Temperature | 10 mg Cocaine with 0 mg Phendimetrazine | 98.12 Degrees Fahrenheit | Standard Error 0.17 |
| Phendimetrazine Dose Escalation | Peak Temperature | 20 mg Cocaine with 0 mg Phendimetrazine | 98.24 Degrees Fahrenheit | Standard Error 0.12 |
| Phendimetrazine Dose Escalation | Peak Temperature | 40 mg Cocaine with 0 mg Phendimetrazine | 98.21 Degrees Fahrenheit | Standard Error 0.15 |
| Phendimetrazine Dose Escalation | Peak Temperature | 80 mg Cocaine with 0 mg Phendimetrazine | 98.04 Degrees Fahrenheit | Standard Error 0.29 |
| Phendimetrazine Dose Escalation | Peak Temperature | 0 mg Cocaine with 70 mg Phendimetrazine | 98.25 Degrees Fahrenheit | Standard Error 0.07 |
| Phendimetrazine Dose Escalation | Peak Temperature | 10 mg Cocaine with 70 mg Phendimetrazine | 98.28 Degrees Fahrenheit | Standard Error 0.08 |
| Phendimetrazine Dose Escalation | Peak Temperature | 20 mg Cocaine with 70 mg Phendimetrazine | 98.25 Degrees Fahrenheit | Standard Error 0.12 |
| Phendimetrazine Dose Escalation | Peak Temperature | 40 mg Cocaine with 70 mg Phendimetrazine | 98.24 Degrees Fahrenheit | Standard Error 0.22 |
| Phendimetrazine Dose Escalation | Peak Temperature | 80 mg Cocaine with 70 mg Phendimetrazine | 98.32 Degrees Fahrenheit | Standard Error 0.17 |
| Phendimetrazine Dose Escalation | Peak Temperature | 0 mg Cocaine with 140 mg Phendimetrazine | 98.19 Degrees Fahrenheit | Standard Error 0.04 |
| Phendimetrazine Dose Escalation | Peak Temperature | 10 mg Cocaine with 140 mg Phendimetrazine | 98.17 Degrees Fahrenheit | Standard Error 0.06 |
| Phendimetrazine Dose Escalation | Peak Temperature | 20 mg Cocaine with 140 mg Phendimetrazine | 98.25 Degrees Fahrenheit | Standard Error 0.05 |
| Phendimetrazine Dose Escalation | Peak Temperature | 40 mg Cocaine with 140 mg Phendimetrazine | 98.2 Degrees Fahrenheit | Standard Error 0.09 |
| Phendimetrazine Dose Escalation | Peak Temperature | 80 mg Cocaine with 140 mg Phendimetrazine | 98.3 Degrees Fahrenheit | Standard Error 0.04 |
| Phendimetrazine Dose Escalation | Peak Temperature | 0 mg Cocaine with 210 mg Phendimetrazine | 98.41 Degrees Fahrenheit | Standard Error 0.07 |
| Phendimetrazine Dose Escalation | Peak Temperature | 10 mg Cocaine with 210 mg Phendimetrazine | 98.17 Degrees Fahrenheit | Standard Error 0.06 |
| Phendimetrazine Dose Escalation | Peak Temperature | 20 mg Cocaine with 210 mg Phendimetrazine | 98.18 Degrees Fahrenheit | Standard Error 0.08 |
| Phendimetrazine Dose Escalation | Peak Temperature | 40 mg Cocaine with 210 mg Phendimetrazine | 98.24 Degrees Fahrenheit | Standard Error 0.07 |
| Phendimetrazine Dose Escalation | Peak Temperature | 80 mg Cocaine with 210 mg Phendimetrazine | 98.38 Degrees Fahrenheit | Standard Error 0.1 |
Secondary
Peak Ratings of Active, Alert, Energetic on the Visual Analog Scale
Subjects rated their feelings of Active, Alert, Energetic on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.
Time frame: This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Phendimetrazine Dose Escalation | Peak Ratings of Active, Alert, Energetic on the Visual Analog Scale | 0 mg Cocaine with 0 mg Phendimetrazine | .6 units on a scale | Standard Error 0.5 |
| Phendimetrazine Dose Escalation | Peak Ratings of Active, Alert, Energetic on the Visual Analog Scale | 10 mg Cocaine with 0 mg Phendimetrazine | 3.9 units on a scale | Standard Error 1.91 |
| Phendimetrazine Dose Escalation | Peak Ratings of Active, Alert, Energetic on the Visual Analog Scale | 20 mg Cocaine with 0 mg Phendimetrazine | 8.9 units on a scale | Standard Error 3.89 |
| Phendimetrazine Dose Escalation | Peak Ratings of Active, Alert, Energetic on the Visual Analog Scale | 40 mg Cocaine with 0 mg Phendimetrazine | 7.8 units on a scale | Standard Error 4.99 |
| Phendimetrazine Dose Escalation | Peak Ratings of Active, Alert, Energetic on the Visual Analog Scale | 80 mg Cocaine with 0 mg Phendimetrazine | 14 units on a scale | Standard Error 6.23 |
| Phendimetrazine Dose Escalation | Peak Ratings of Active, Alert, Energetic on the Visual Analog Scale | 0 mg Cocaine with 70 mg Phendimetrazine | 1.5 units on a scale | Standard Error 1 |
| Phendimetrazine Dose Escalation | Peak Ratings of Active, Alert, Energetic on the Visual Analog Scale | 10 mg Cocaine with 70 mg Phendimetrazine | 6 units on a scale | Standard Error 2.28 |
| Phendimetrazine Dose Escalation | Peak Ratings of Active, Alert, Energetic on the Visual Analog Scale | 20 mg Cocaine with 70 mg Phendimetrazine | 9 units on a scale | Standard Error 3.87 |
| Phendimetrazine Dose Escalation | Peak Ratings of Active, Alert, Energetic on the Visual Analog Scale | 40 mg Cocaine with 70 mg Phendimetrazine | 13.4 units on a scale | Standard Error 3.91 |
| Phendimetrazine Dose Escalation | Peak Ratings of Active, Alert, Energetic on the Visual Analog Scale | 80 mg Cocaine with 70 mg Phendimetrazine | 16 units on a scale | Standard Error 4.17 |
| Phendimetrazine Dose Escalation | Peak Ratings of Active, Alert, Energetic on the Visual Analog Scale | 0 mg Cocaine with 140 mg Phendimetrazine | .7 units on a scale | Standard Error 0.6 |
| Phendimetrazine Dose Escalation | Peak Ratings of Active, Alert, Energetic on the Visual Analog Scale | 10 mg Cocaine with 140 mg Phendimetrazine | 4 units on a scale | Standard Error 1.76 |
| Phendimetrazine Dose Escalation | Peak Ratings of Active, Alert, Energetic on the Visual Analog Scale | 20 mg Cocaine with 140 mg Phendimetrazine | 11.4 units on a scale | Standard Error 4.7 |
| Phendimetrazine Dose Escalation | Peak Ratings of Active, Alert, Energetic on the Visual Analog Scale | 40 mg Cocaine with 140 mg Phendimetrazine | 14.8 units on a scale | Standard Error 4.7 |
| Phendimetrazine Dose Escalation | Peak Ratings of Active, Alert, Energetic on the Visual Analog Scale | 80 mg Cocaine with 140 mg Phendimetrazine | 18.9 units on a scale | Standard Error 5.31 |
| Phendimetrazine Dose Escalation | Peak Ratings of Active, Alert, Energetic on the Visual Analog Scale | 0 mg Cocaine with 210 mg Phendimetrazine | 1 units on a scale | Standard Error 0.89 |
| Phendimetrazine Dose Escalation | Peak Ratings of Active, Alert, Energetic on the Visual Analog Scale | 10 mg Cocaine with 210 mg Phendimetrazine | 1.8 units on a scale | Standard Error 0.85 |
| Phendimetrazine Dose Escalation | Peak Ratings of Active, Alert, Energetic on the Visual Analog Scale | 20 mg Cocaine with 210 mg Phendimetrazine | 10.1 units on a scale | Standard Error 3.71 |
| Phendimetrazine Dose Escalation | Peak Ratings of Active, Alert, Energetic on the Visual Analog Scale | 40 mg Cocaine with 210 mg Phendimetrazine | 11.1 units on a scale | Standard Error 3.89 |
| Phendimetrazine Dose Escalation | Peak Ratings of Active, Alert, Energetic on the Visual Analog Scale | 80 mg Cocaine with 210 mg Phendimetrazine | 17 units on a scale | Standard Error 5.8 |
Secondary
Peak Ratings of Any Effect on the Visual Analog Scale
Subjects rated their feelings of Any Effect on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.
Time frame: This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Phendimetrazine Dose Escalation | Peak Ratings of Any Effect on the Visual Analog Scale | 0 mg Cocaine with 0 mg Phendimetrazine | 1.5 units on a scale | Standard Error 0.83 |
| Phendimetrazine Dose Escalation | Peak Ratings of Any Effect on the Visual Analog Scale | 10 mg Cocaine with 0 mg Phendimetrazine | 4.7 units on a scale | Standard Error 1.57 |
| Phendimetrazine Dose Escalation | Peak Ratings of Any Effect on the Visual Analog Scale | 20 mg Cocaine with 0 mg Phendimetrazine | 13.2 units on a scale | Standard Error 4.93 |
| Phendimetrazine Dose Escalation | Peak Ratings of Any Effect on the Visual Analog Scale | 40 mg Cocaine with 0 mg Phendimetrazine | 16.9 units on a scale | Standard Error 4.32 |
| Phendimetrazine Dose Escalation | Peak Ratings of Any Effect on the Visual Analog Scale | 80 mg Cocaine with 0 mg Phendimetrazine | 26 units on a scale | Standard Error 6.53 |
| Phendimetrazine Dose Escalation | Peak Ratings of Any Effect on the Visual Analog Scale | 0 mg Cocaine with 70 mg Phendimetrazine | .9 units on a scale | Standard Error 0.64 |
| Phendimetrazine Dose Escalation | Peak Ratings of Any Effect on the Visual Analog Scale | 10 mg Cocaine with 70 mg Phendimetrazine | 7.7 units on a scale | Standard Error 2.59 |
| Phendimetrazine Dose Escalation | Peak Ratings of Any Effect on the Visual Analog Scale | 20 mg Cocaine with 70 mg Phendimetrazine | 13.5 units on a scale | Standard Error 4.84 |
| Phendimetrazine Dose Escalation | Peak Ratings of Any Effect on the Visual Analog Scale | 40 mg Cocaine with 70 mg Phendimetrazine | 21.2 units on a scale | Standard Error 6.9 |
| Phendimetrazine Dose Escalation | Peak Ratings of Any Effect on the Visual Analog Scale | 80 mg Cocaine with 70 mg Phendimetrazine | 27.3 units on a scale | Standard Error 7.81 |
| Phendimetrazine Dose Escalation | Peak Ratings of Any Effect on the Visual Analog Scale | 0 mg Cocaine with 140 mg Phendimetrazine | .5 units on a scale | Standard Error 0.5 |
| Phendimetrazine Dose Escalation | Peak Ratings of Any Effect on the Visual Analog Scale | 10 mg Cocaine with 140 mg Phendimetrazine | 7 units on a scale | Standard Error 1.99 |
| Phendimetrazine Dose Escalation | Peak Ratings of Any Effect on the Visual Analog Scale | 20 mg Cocaine with 140 mg Phendimetrazine | 12.8 units on a scale | Standard Error 3.59 |
| Phendimetrazine Dose Escalation | Peak Ratings of Any Effect on the Visual Analog Scale | 40 mg Cocaine with 140 mg Phendimetrazine | 19 units on a scale | Standard Error 4.96 |
| Phendimetrazine Dose Escalation | Peak Ratings of Any Effect on the Visual Analog Scale | 80 mg Cocaine with 140 mg Phendimetrazine | 28.1 units on a scale | Standard Error 4.86 |
| Phendimetrazine Dose Escalation | Peak Ratings of Any Effect on the Visual Analog Scale | 0 mg Cocaine with 210 mg Phendimetrazine | 4.6 units on a scale | Standard Error 2.74 |
| Phendimetrazine Dose Escalation | Peak Ratings of Any Effect on the Visual Analog Scale | 10 mg Cocaine with 210 mg Phendimetrazine | 10.5 units on a scale | Standard Error 3.37 |
| Phendimetrazine Dose Escalation | Peak Ratings of Any Effect on the Visual Analog Scale | 20 mg Cocaine with 210 mg Phendimetrazine | 14.7 units on a scale | Standard Error 4.33 |
| Phendimetrazine Dose Escalation | Peak Ratings of Any Effect on the Visual Analog Scale | 40 mg Cocaine with 210 mg Phendimetrazine | 21.5 units on a scale | Standard Error 4.25 |
| Phendimetrazine Dose Escalation | Peak Ratings of Any Effect on the Visual Analog Scale | 80 mg Cocaine with 210 mg Phendimetrazine | 35.1 units on a scale | Standard Error 7.54 |
Secondary
Peak Ratings of Bad Effect on the Visual Analog Scale
Subjects rated their feelings of Bad Effect on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.
Time frame: This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Phendimetrazine Dose Escalation | Peak Ratings of Bad Effect on the Visual Analog Scale | 0 mg Cocaine with 0 mg Phendimetrazine | .6 units on a scale | Standard Error 0.4 |
| Phendimetrazine Dose Escalation | Peak Ratings of Bad Effect on the Visual Analog Scale | 10 mg Cocaine with 0 mg Phendimetrazine | 2.1 units on a scale | Standard Error 1.3 |
| Phendimetrazine Dose Escalation | Peak Ratings of Bad Effect on the Visual Analog Scale | 20 mg Cocaine with 0 mg Phendimetrazine | 4.9 units on a scale | Standard Error 3.52 |
| Phendimetrazine Dose Escalation | Peak Ratings of Bad Effect on the Visual Analog Scale | 40 mg Cocaine with 0 mg Phendimetrazine | 6.6 units on a scale | Standard Error 4.04 |
| Phendimetrazine Dose Escalation | Peak Ratings of Bad Effect on the Visual Analog Scale | 80 mg Cocaine with 0 mg Phendimetrazine | 8.5 units on a scale | Standard Error 4.74 |
| Phendimetrazine Dose Escalation | Peak Ratings of Bad Effect on the Visual Analog Scale | 0 mg Cocaine with 70 mg Phendimetrazine | 1.3 units on a scale | Standard Error 0.87 |
| Phendimetrazine Dose Escalation | Peak Ratings of Bad Effect on the Visual Analog Scale | 10 mg Cocaine with 70 mg Phendimetrazine | 2 units on a scale | Standard Error 1.42 |
| Phendimetrazine Dose Escalation | Peak Ratings of Bad Effect on the Visual Analog Scale | 20 mg Cocaine with 70 mg Phendimetrazine | 5.6 units on a scale | Standard Error 2.4 |
| Phendimetrazine Dose Escalation | Peak Ratings of Bad Effect on the Visual Analog Scale | 40 mg Cocaine with 70 mg Phendimetrazine | 4.9 units on a scale | Standard Error 2.7 |
| Phendimetrazine Dose Escalation | Peak Ratings of Bad Effect on the Visual Analog Scale | 80 mg Cocaine with 70 mg Phendimetrazine | 5.6 units on a scale | Standard Error 3.73 |
| Phendimetrazine Dose Escalation | Peak Ratings of Bad Effect on the Visual Analog Scale | 0 mg Cocaine with 140 mg Phendimetrazine | .7 units on a scale | Standard Error 0.7 |
| Phendimetrazine Dose Escalation | Peak Ratings of Bad Effect on the Visual Analog Scale | 10 mg Cocaine with 140 mg Phendimetrazine | 1.9 units on a scale | Standard Error 1.33 |
| Phendimetrazine Dose Escalation | Peak Ratings of Bad Effect on the Visual Analog Scale | 20 mg Cocaine with 140 mg Phendimetrazine | 5.7 units on a scale | Standard Error 3.14 |
| Phendimetrazine Dose Escalation | Peak Ratings of Bad Effect on the Visual Analog Scale | 40 mg Cocaine with 140 mg Phendimetrazine | 3.7 units on a scale | Standard Error 2.63 |
| Phendimetrazine Dose Escalation | Peak Ratings of Bad Effect on the Visual Analog Scale | 80 mg Cocaine with 140 mg Phendimetrazine | 11.4 units on a scale | Standard Error 5.39 |
| Phendimetrazine Dose Escalation | Peak Ratings of Bad Effect on the Visual Analog Scale | 0 mg Cocaine with 210 mg Phendimetrazine | 9.2 units on a scale | Standard Error 7.77 |
| Phendimetrazine Dose Escalation | Peak Ratings of Bad Effect on the Visual Analog Scale | 10 mg Cocaine with 210 mg Phendimetrazine | 2.4 units on a scale | Standard Error 1.52 |
| Phendimetrazine Dose Escalation | Peak Ratings of Bad Effect on the Visual Analog Scale | 20 mg Cocaine with 210 mg Phendimetrazine | 3.9 units on a scale | Standard Error 2.17 |
| Phendimetrazine Dose Escalation | Peak Ratings of Bad Effect on the Visual Analog Scale | 40 mg Cocaine with 210 mg Phendimetrazine | 8.1 units on a scale | Standard Error 4.45 |
| Phendimetrazine Dose Escalation | Peak Ratings of Bad Effect on the Visual Analog Scale | 80 mg Cocaine with 210 mg Phendimetrazine | 10.2 units on a scale | Standard Error 7.23 |
Secondary
Peak Ratings of Euphoric on the Visual Analog Scale
Subjects rated their feelings of Euphoric on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.
Time frame: This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Phendimetrazine Dose Escalation | Peak Ratings of Euphoric on the Visual Analog Scale | 0 mg Cocaine with 0 mg Phendimetrazine | 1 units on a scale | Standard Error 0.89 |
| Phendimetrazine Dose Escalation | Peak Ratings of Euphoric on the Visual Analog Scale | 10 mg Cocaine with 0 mg Phendimetrazine | 1.8 units on a scale | Standard Error 0.87 |
| Phendimetrazine Dose Escalation | Peak Ratings of Euphoric on the Visual Analog Scale | 20 mg Cocaine with 0 mg Phendimetrazine | 3.1 units on a scale | Standard Error 1.87 |
| Phendimetrazine Dose Escalation | Peak Ratings of Euphoric on the Visual Analog Scale | 40 mg Cocaine with 0 mg Phendimetrazine | 1.2 units on a scale | Standard Error 0.81 |
| Phendimetrazine Dose Escalation | Peak Ratings of Euphoric on the Visual Analog Scale | 80 mg Cocaine with 0 mg Phendimetrazine | 1.9 units on a scale | Standard Error 1.32 |
| Phendimetrazine Dose Escalation | Peak Ratings of Euphoric on the Visual Analog Scale | 0 mg Cocaine with 70 mg Phendimetrazine | 1 units on a scale | Standard Error 0.6 |
| Phendimetrazine Dose Escalation | Peak Ratings of Euphoric on the Visual Analog Scale | 10 mg Cocaine with 70 mg Phendimetrazine | 1 units on a scale | Standard Error 0.52 |
| Phendimetrazine Dose Escalation | Peak Ratings of Euphoric on the Visual Analog Scale | 20 mg Cocaine with 70 mg Phendimetrazine | 3.2 units on a scale | Standard Error 1.52 |
| Phendimetrazine Dose Escalation | Peak Ratings of Euphoric on the Visual Analog Scale | 40 mg Cocaine with 70 mg Phendimetrazine | 1.2 units on a scale | Standard Error 0.63 |
| Phendimetrazine Dose Escalation | Peak Ratings of Euphoric on the Visual Analog Scale | 80 mg Cocaine with 70 mg Phendimetrazine | 2 units on a scale | Standard Error 1 |
| Phendimetrazine Dose Escalation | Peak Ratings of Euphoric on the Visual Analog Scale | 0 mg Cocaine with 140 mg Phendimetrazine | .9 units on a scale | Standard Error 0.64 |
| Phendimetrazine Dose Escalation | Peak Ratings of Euphoric on the Visual Analog Scale | 10 mg Cocaine with 140 mg Phendimetrazine | 2 units on a scale | Standard Error 1.16 |
| Phendimetrazine Dose Escalation | Peak Ratings of Euphoric on the Visual Analog Scale | 20 mg Cocaine with 140 mg Phendimetrazine | 1.3 units on a scale | Standard Error 0.7 |
| Phendimetrazine Dose Escalation | Peak Ratings of Euphoric on the Visual Analog Scale | 40 mg Cocaine with 140 mg Phendimetrazine | 1 units on a scale | Standard Error 0.54 |
| Phendimetrazine Dose Escalation | Peak Ratings of Euphoric on the Visual Analog Scale | 80 mg Cocaine with 140 mg Phendimetrazine | 1.3 units on a scale | Standard Error 0.7 |
| Phendimetrazine Dose Escalation | Peak Ratings of Euphoric on the Visual Analog Scale | 0 mg Cocaine with 210 mg Phendimetrazine | .9 units on a scale | Standard Error 0.48 |
| Phendimetrazine Dose Escalation | Peak Ratings of Euphoric on the Visual Analog Scale | 10 mg Cocaine with 210 mg Phendimetrazine | .4 units on a scale | Standard Error 0.4 |
| Phendimetrazine Dose Escalation | Peak Ratings of Euphoric on the Visual Analog Scale | 20 mg Cocaine with 210 mg Phendimetrazine | 1 units on a scale | Standard Error 0.68 |
| Phendimetrazine Dose Escalation | Peak Ratings of Euphoric on the Visual Analog Scale | 40 mg Cocaine with 210 mg Phendimetrazine | .8 units on a scale | Standard Error 0.47 |
| Phendimetrazine Dose Escalation | Peak Ratings of Euphoric on the Visual Analog Scale | 80 mg Cocaine with 210 mg Phendimetrazine | 1.7 units on a scale | Standard Error 0.82 |
Secondary
Peak Ratings of Good Effect on the Visual Analog Scale
Subjects rated their feelings of Good Effect on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.
Time frame: This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Phendimetrazine Dose Escalation | Peak Ratings of Good Effect on the Visual Analog Scale | 40 mg Cocaine with 70 mg Phendimetrazine | 15.3 units on a scale | Standard Error 5.14 |
| Phendimetrazine Dose Escalation | Peak Ratings of Good Effect on the Visual Analog Scale | 80 mg Cocaine with 70 mg Phendimetrazine | 21.3 units on a scale | Standard Error 5.57 |
| Phendimetrazine Dose Escalation | Peak Ratings of Good Effect on the Visual Analog Scale | 0 mg Cocaine with 140 mg Phendimetrazine | 2.1 units on a scale | Standard Error 1.13 |
| Phendimetrazine Dose Escalation | Peak Ratings of Good Effect on the Visual Analog Scale | 10 mg Cocaine with 140 mg Phendimetrazine | 8.1 units on a scale | Standard Error 2.67 |
| Phendimetrazine Dose Escalation | Peak Ratings of Good Effect on the Visual Analog Scale | 20 mg Cocaine with 140 mg Phendimetrazine | 7.9 units on a scale | Standard Error 3.9 |
| Phendimetrazine Dose Escalation | Peak Ratings of Good Effect on the Visual Analog Scale | 40 mg Cocaine with 140 mg Phendimetrazine | 15.4 units on a scale | Standard Error 5.39 |
| Phendimetrazine Dose Escalation | Peak Ratings of Good Effect on the Visual Analog Scale | 80 mg Cocaine with 140 mg Phendimetrazine | 27.8 units on a scale | Standard Error 6.5 |
| Phendimetrazine Dose Escalation | Peak Ratings of Good Effect on the Visual Analog Scale | 0 mg Cocaine with 210 mg Phendimetrazine | 9.2 units on a scale | Standard Error 7.77 |
| Phendimetrazine Dose Escalation | Peak Ratings of Good Effect on the Visual Analog Scale | 10 mg Cocaine with 210 mg Phendimetrazine | 12 units on a scale | Standard Error 4.51 |
| Phendimetrazine Dose Escalation | Peak Ratings of Good Effect on the Visual Analog Scale | 20 mg Cocaine with 210 mg Phendimetrazine | 16.7 units on a scale | Standard Error 6.33 |
| Phendimetrazine Dose Escalation | Peak Ratings of Good Effect on the Visual Analog Scale | 40 mg Cocaine with 210 mg Phendimetrazine | 17.1 units on a scale | Standard Error 4.33 |
| Phendimetrazine Dose Escalation | Peak Ratings of Good Effect on the Visual Analog Scale | 80 mg Cocaine with 210 mg Phendimetrazine | 27.2 units on a scale | Standard Error 7.56 |
| Phendimetrazine Dose Escalation | Peak Ratings of Good Effect on the Visual Analog Scale | 0 mg Cocaine with 0 mg Phendimetrazine | 1.2 units on a scale | Standard Error 0.73 |
| Phendimetrazine Dose Escalation | Peak Ratings of Good Effect on the Visual Analog Scale | 10 mg Cocaine with 0 mg Phendimetrazine | 7.1 units on a scale | Standard Error 2.74 |
| Phendimetrazine Dose Escalation | Peak Ratings of Good Effect on the Visual Analog Scale | 20 mg Cocaine with 0 mg Phendimetrazine | 12.4 units on a scale | Standard Error 4.61 |
| Phendimetrazine Dose Escalation | Peak Ratings of Good Effect on the Visual Analog Scale | 40 mg Cocaine with 0 mg Phendimetrazine | 12.3 units on a scale | Standard Error 5.27 |
| Phendimetrazine Dose Escalation | Peak Ratings of Good Effect on the Visual Analog Scale | 80 mg Cocaine with 0 mg Phendimetrazine | 19.8 units on a scale | Standard Error 7.01 |
| Phendimetrazine Dose Escalation | Peak Ratings of Good Effect on the Visual Analog Scale | 0 mg Cocaine with 70 mg Phendimetrazine | 1.3 units on a scale | Standard Error 0.94 |
| Phendimetrazine Dose Escalation | Peak Ratings of Good Effect on the Visual Analog Scale | 10 mg Cocaine with 70 mg Phendimetrazine | 7.1 units on a scale | Standard Error 2.48 |
| Phendimetrazine Dose Escalation | Peak Ratings of Good Effect on the Visual Analog Scale | 20 mg Cocaine with 70 mg Phendimetrazine | 11.7 units on a scale | Standard Error 3.77 |
Secondary
Peak Ratings of High on the Visual Analog Scale
Subjects rated their feelings of High on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.
Time frame: This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Phendimetrazine Dose Escalation | Peak Ratings of High on the Visual Analog Scale | 0 mg Cocaine with 0 mg Phendimetrazine | 1.4 units on a scale | Standard Error 0.69 |
| Phendimetrazine Dose Escalation | Peak Ratings of High on the Visual Analog Scale | 10 mg Cocaine with 0 mg Phendimetrazine | 6 units on a scale | Standard Error 2.29 |
| Phendimetrazine Dose Escalation | Peak Ratings of High on the Visual Analog Scale | 20 mg Cocaine with 0 mg Phendimetrazine | 14.1 units on a scale | Standard Error 4.9 |
| Phendimetrazine Dose Escalation | Peak Ratings of High on the Visual Analog Scale | 40 mg Cocaine with 0 mg Phendimetrazine | 11.9 units on a scale | Standard Error 4.81 |
| Phendimetrazine Dose Escalation | Peak Ratings of High on the Visual Analog Scale | 80 mg Cocaine with 0 mg Phendimetrazine | 23.4 units on a scale | Standard Error 6.42 |
| Phendimetrazine Dose Escalation | Peak Ratings of High on the Visual Analog Scale | 0 mg Cocaine with 70 mg Phendimetrazine | 1.1 units on a scale | Standard Error 0.6 |
| Phendimetrazine Dose Escalation | Peak Ratings of High on the Visual Analog Scale | 10 mg Cocaine with 70 mg Phendimetrazine | 3.6 units on a scale | Standard Error 1.18 |
| Phendimetrazine Dose Escalation | Peak Ratings of High on the Visual Analog Scale | 20 mg Cocaine with 70 mg Phendimetrazine | 10.8 units on a scale | Standard Error 4.14 |
| Phendimetrazine Dose Escalation | Peak Ratings of High on the Visual Analog Scale | 40 mg Cocaine with 70 mg Phendimetrazine | 13.3 units on a scale | Standard Error 5.55 |
| Phendimetrazine Dose Escalation | Peak Ratings of High on the Visual Analog Scale | 80 mg Cocaine with 70 mg Phendimetrazine | 18.6 units on a scale | Standard Error 6.52 |
| Phendimetrazine Dose Escalation | Peak Ratings of High on the Visual Analog Scale | 0 mg Cocaine with 140 mg Phendimetrazine | .6 units on a scale | Standard Error 0.5 |
| Phendimetrazine Dose Escalation | Peak Ratings of High on the Visual Analog Scale | 10 mg Cocaine with 140 mg Phendimetrazine | 6.3 units on a scale | Standard Error 2.96 |
| Phendimetrazine Dose Escalation | Peak Ratings of High on the Visual Analog Scale | 20 mg Cocaine with 140 mg Phendimetrazine | 9.1 units on a scale | Standard Error 4.39 |
| Phendimetrazine Dose Escalation | Peak Ratings of High on the Visual Analog Scale | 40 mg Cocaine with 140 mg Phendimetrazine | 15.8 units on a scale | Standard Error 5.96 |
| Phendimetrazine Dose Escalation | Peak Ratings of High on the Visual Analog Scale | 80 mg Cocaine with 140 mg Phendimetrazine | 24.2 units on a scale | Standard Error 6.77 |
| Phendimetrazine Dose Escalation | Peak Ratings of High on the Visual Analog Scale | 0 mg Cocaine with 210 mg Phendimetrazine | .8 units on a scale | Standard Error 0.59 |
| Phendimetrazine Dose Escalation | Peak Ratings of High on the Visual Analog Scale | 10 mg Cocaine with 210 mg Phendimetrazine | 8.3 units on a scale | Standard Error 4.14 |
| Phendimetrazine Dose Escalation | Peak Ratings of High on the Visual Analog Scale | 20 mg Cocaine with 210 mg Phendimetrazine | 15.3 units on a scale | Standard Error 6.35 |
| Phendimetrazine Dose Escalation | Peak Ratings of High on the Visual Analog Scale | 40 mg Cocaine with 210 mg Phendimetrazine | 12.1 units on a scale | Standard Error 3.14 |
| Phendimetrazine Dose Escalation | Peak Ratings of High on the Visual Analog Scale | 80 mg Cocaine with 210 mg Phendimetrazine | 22.6 units on a scale | Standard Error 7.05 |
Secondary
Peak Ratings of Irregular/Racing Heartbeat on the Visual Analog Scale
Subjects rated their feelings of Irregular/Racing Heartbeat on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.
Time frame: This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Phendimetrazine Dose Escalation | Peak Ratings of Irregular/Racing Heartbeat on the Visual Analog Scale | 0 mg Cocaine with 0 mg Phendimetrazine | .8 units on a scale | Standard Error 0.51 |
| Phendimetrazine Dose Escalation | Peak Ratings of Irregular/Racing Heartbeat on the Visual Analog Scale | 10 mg Cocaine with 0 mg Phendimetrazine | 2.8 units on a scale | Standard Error 1.19 |
| Phendimetrazine Dose Escalation | Peak Ratings of Irregular/Racing Heartbeat on the Visual Analog Scale | 20 mg Cocaine with 0 mg Phendimetrazine | 10.8 units on a scale | Standard Error 4.07 |
| Phendimetrazine Dose Escalation | Peak Ratings of Irregular/Racing Heartbeat on the Visual Analog Scale | 40 mg Cocaine with 0 mg Phendimetrazine | 9.2 units on a scale | Standard Error 5 |
| Phendimetrazine Dose Escalation | Peak Ratings of Irregular/Racing Heartbeat on the Visual Analog Scale | 80 mg Cocaine with 0 mg Phendimetrazine | 14.6 units on a scale | Standard Error 7 |
| Phendimetrazine Dose Escalation | Peak Ratings of Irregular/Racing Heartbeat on the Visual Analog Scale | 0 mg Cocaine with 70 mg Phendimetrazine | .4 units on a scale | Standard Error 0.4 |
| Phendimetrazine Dose Escalation | Peak Ratings of Irregular/Racing Heartbeat on the Visual Analog Scale | 10 mg Cocaine with 70 mg Phendimetrazine | 1.6 units on a scale | Standard Error 0.6 |
| Phendimetrazine Dose Escalation | Peak Ratings of Irregular/Racing Heartbeat on the Visual Analog Scale | 20 mg Cocaine with 70 mg Phendimetrazine | 6.9 units on a scale | Standard Error 3.7 |
| Phendimetrazine Dose Escalation | Peak Ratings of Irregular/Racing Heartbeat on the Visual Analog Scale | 40 mg Cocaine with 70 mg Phendimetrazine | 2.4 units on a scale | Standard Error 1.3 |
| Phendimetrazine Dose Escalation | Peak Ratings of Irregular/Racing Heartbeat on the Visual Analog Scale | 80 mg Cocaine with 70 mg Phendimetrazine | 6 units on a scale | Standard Error 2.9 |
| Phendimetrazine Dose Escalation | Peak Ratings of Irregular/Racing Heartbeat on the Visual Analog Scale | 0 mg Cocaine with 140 mg Phendimetrazine | .6 units on a scale | Standard Error 0.4 |
| Phendimetrazine Dose Escalation | Peak Ratings of Irregular/Racing Heartbeat on the Visual Analog Scale | 10 mg Cocaine with 140 mg Phendimetrazine | .8 units on a scale | Standard Error 0.55 |
| Phendimetrazine Dose Escalation | Peak Ratings of Irregular/Racing Heartbeat on the Visual Analog Scale | 20 mg Cocaine with 140 mg Phendimetrazine | 3.6 units on a scale | Standard Error 2.56 |
| Phendimetrazine Dose Escalation | Peak Ratings of Irregular/Racing Heartbeat on the Visual Analog Scale | 40 mg Cocaine with 140 mg Phendimetrazine | 5.10 units on a scale | Standard Error 2.15 |
| Phendimetrazine Dose Escalation | Peak Ratings of Irregular/Racing Heartbeat on the Visual Analog Scale | 80 mg Cocaine with 140 mg Phendimetrazine | 8.2 units on a scale | Standard Error 4.17 |
| Phendimetrazine Dose Escalation | Peak Ratings of Irregular/Racing Heartbeat on the Visual Analog Scale | 0 mg Cocaine with 210 mg Phendimetrazine | 2.3 units on a scale | Standard Error 1.21 |
| Phendimetrazine Dose Escalation | Peak Ratings of Irregular/Racing Heartbeat on the Visual Analog Scale | 10 mg Cocaine with 210 mg Phendimetrazine | .6 units on a scale | Standard Error 0.5 |
| Phendimetrazine Dose Escalation | Peak Ratings of Irregular/Racing Heartbeat on the Visual Analog Scale | 20 mg Cocaine with 210 mg Phendimetrazine | 4 units on a scale | Standard Error 3.36 |
| Phendimetrazine Dose Escalation | Peak Ratings of Irregular/Racing Heartbeat on the Visual Analog Scale | 40 mg Cocaine with 210 mg Phendimetrazine | 5.5 units on a scale | Standard Error 3.48 |
| Phendimetrazine Dose Escalation | Peak Ratings of Irregular/Racing Heartbeat on the Visual Analog Scale | 80 mg Cocaine with 210 mg Phendimetrazine | 9.8 units on a scale | Standard Error 4.85 |
Secondary
Peak Ratings of Like Drug on the Visual Analog Scale
Subjects rated their feelings of Like Drug on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.
Time frame: This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Phendimetrazine Dose Escalation | Peak Ratings of Like Drug on the Visual Analog Scale | 0 mg Cocaine with 0 mg Phendimetrazine | 1 units on a scale | Standard Error 0.54 |
| Phendimetrazine Dose Escalation | Peak Ratings of Like Drug on the Visual Analog Scale | 10 mg Cocaine with 0 mg Phendimetrazine | 6.4 units on a scale | Standard Error 2.01 |
| Phendimetrazine Dose Escalation | Peak Ratings of Like Drug on the Visual Analog Scale | 20 mg Cocaine with 0 mg Phendimetrazine | 12.9 units on a scale | Standard Error 4.58 |
| Phendimetrazine Dose Escalation | Peak Ratings of Like Drug on the Visual Analog Scale | 40 mg Cocaine with 0 mg Phendimetrazine | 14 units on a scale | Standard Error 5.82 |
| Phendimetrazine Dose Escalation | Peak Ratings of Like Drug on the Visual Analog Scale | 80 mg Cocaine with 0 mg Phendimetrazine | 23.2 units on a scale | Standard Error 8.32 |
| Phendimetrazine Dose Escalation | Peak Ratings of Like Drug on the Visual Analog Scale | 0 mg Cocaine with 70 mg Phendimetrazine | .5 units on a scale | Standard Error 0.5 |
| Phendimetrazine Dose Escalation | Peak Ratings of Like Drug on the Visual Analog Scale | 10 mg Cocaine with 70 mg Phendimetrazine | 4.1 units on a scale | Standard Error 1.49 |
| Phendimetrazine Dose Escalation | Peak Ratings of Like Drug on the Visual Analog Scale | 20 mg Cocaine with 70 mg Phendimetrazine | 10.7 units on a scale | Standard Error 3.52 |
| Phendimetrazine Dose Escalation | Peak Ratings of Like Drug on the Visual Analog Scale | 40 mg Cocaine with 70 mg Phendimetrazine | 17.9 units on a scale | Standard Error 5.13 |
| Phendimetrazine Dose Escalation | Peak Ratings of Like Drug on the Visual Analog Scale | 80 mg Cocaine with 70 mg Phendimetrazine | 25 units on a scale | Standard Error 6.93 |
| Phendimetrazine Dose Escalation | Peak Ratings of Like Drug on the Visual Analog Scale | 0 mg Cocaine with 140 mg Phendimetrazine | 1.2 units on a scale | Standard Error 0.8 |
| Phendimetrazine Dose Escalation | Peak Ratings of Like Drug on the Visual Analog Scale | 10 mg Cocaine with 140 mg Phendimetrazine | 9.8 units on a scale | Standard Error 3.16 |
| Phendimetrazine Dose Escalation | Peak Ratings of Like Drug on the Visual Analog Scale | 20 mg Cocaine with 140 mg Phendimetrazine | 9.9 units on a scale | Standard Error 3.93 |
| Phendimetrazine Dose Escalation | Peak Ratings of Like Drug on the Visual Analog Scale | 40 mg Cocaine with 140 mg Phendimetrazine | 18 units on a scale | Standard Error 6.01 |
| Phendimetrazine Dose Escalation | Peak Ratings of Like Drug on the Visual Analog Scale | 80 mg Cocaine with 140 mg Phendimetrazine | 26.2 units on a scale | Standard Error 6.32 |
| Phendimetrazine Dose Escalation | Peak Ratings of Like Drug on the Visual Analog Scale | 0 mg Cocaine with 210 mg Phendimetrazine | 2.2 units on a scale | Standard Error 1.44 |
| Phendimetrazine Dose Escalation | Peak Ratings of Like Drug on the Visual Analog Scale | 10 mg Cocaine with 210 mg Phendimetrazine | 7.5 units on a scale | Standard Error 2.66 |
| Phendimetrazine Dose Escalation | Peak Ratings of Like Drug on the Visual Analog Scale | 20 mg Cocaine with 210 mg Phendimetrazine | 13.1 units on a scale | Standard Error 4.72 |
| Phendimetrazine Dose Escalation | Peak Ratings of Like Drug on the Visual Analog Scale | 40 mg Cocaine with 210 mg Phendimetrazine | 25.5 units on a scale | Standard Error 9.3 |
| Phendimetrazine Dose Escalation | Peak Ratings of Like Drug on the Visual Analog Scale | 80 mg Cocaine with 210 mg Phendimetrazine | 26.5 units on a scale | Standard Error 8.32 |
Secondary
Peak Ratings of Nauseated/Queasy/Sick to Stomach on the Visual Analog Scale
Subjects rated their feelings of Nauseated/Queasy/Sick to Stomach on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.
Time frame: This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Phendimetrazine Dose Escalation | Peak Ratings of Nauseated/Queasy/Sick to Stomach on the Visual Analog Scale | 0 mg Cocaine with 0 mg Phendimetrazine | 1.4 units on a scale | Standard Error 0.69 |
| Phendimetrazine Dose Escalation | Peak Ratings of Nauseated/Queasy/Sick to Stomach on the Visual Analog Scale | 10 mg Cocaine with 0 mg Phendimetrazine | 3.3 units on a scale | Standard Error 1.54 |
| Phendimetrazine Dose Escalation | Peak Ratings of Nauseated/Queasy/Sick to Stomach on the Visual Analog Scale | 20 mg Cocaine with 0 mg Phendimetrazine | 3.1 units on a scale | Standard Error 1.29 |
| Phendimetrazine Dose Escalation | Peak Ratings of Nauseated/Queasy/Sick to Stomach on the Visual Analog Scale | 40 mg Cocaine with 0 mg Phendimetrazine | 7.8 units on a scale | Standard Error 2.59 |
| Phendimetrazine Dose Escalation | Peak Ratings of Nauseated/Queasy/Sick to Stomach on the Visual Analog Scale | 80 mg Cocaine with 0 mg Phendimetrazine | 14 units on a scale | Standard Error 5.79 |
| Phendimetrazine Dose Escalation | Peak Ratings of Nauseated/Queasy/Sick to Stomach on the Visual Analog Scale | 0 mg Cocaine with 70 mg Phendimetrazine | .6 units on a scale | Standard Error 0.43 |
| Phendimetrazine Dose Escalation | Peak Ratings of Nauseated/Queasy/Sick to Stomach on the Visual Analog Scale | 10 mg Cocaine with 70 mg Phendimetrazine | 4.3 units on a scale | Standard Error 2.32 |
| Phendimetrazine Dose Escalation | Peak Ratings of Nauseated/Queasy/Sick to Stomach on the Visual Analog Scale | 20 mg Cocaine with 70 mg Phendimetrazine | 4.3 units on a scale | Standard Error 2.17 |
| Phendimetrazine Dose Escalation | Peak Ratings of Nauseated/Queasy/Sick to Stomach on the Visual Analog Scale | 40 mg Cocaine with 70 mg Phendimetrazine | 5.3 units on a scale | Standard Error 4.22 |
| Phendimetrazine Dose Escalation | Peak Ratings of Nauseated/Queasy/Sick to Stomach on the Visual Analog Scale | 80 mg Cocaine with 70 mg Phendimetrazine | 10.5 units on a scale | Standard Error 5.45 |
| Phendimetrazine Dose Escalation | Peak Ratings of Nauseated/Queasy/Sick to Stomach on the Visual Analog Scale | 0 mg Cocaine with 140 mg Phendimetrazine | .6 units on a scale | Standard Error 0.5 |
| Phendimetrazine Dose Escalation | Peak Ratings of Nauseated/Queasy/Sick to Stomach on the Visual Analog Scale | 10 mg Cocaine with 140 mg Phendimetrazine | 4.1 units on a scale | Standard Error 2.77 |
| Phendimetrazine Dose Escalation | Peak Ratings of Nauseated/Queasy/Sick to Stomach on the Visual Analog Scale | 20 mg Cocaine with 140 mg Phendimetrazine | 2.9 units on a scale | Standard Error 1.96 |
| Phendimetrazine Dose Escalation | Peak Ratings of Nauseated/Queasy/Sick to Stomach on the Visual Analog Scale | 40 mg Cocaine with 140 mg Phendimetrazine | 6.9 units on a scale | Standard Error 3.59 |
| Phendimetrazine Dose Escalation | Peak Ratings of Nauseated/Queasy/Sick to Stomach on the Visual Analog Scale | 80 mg Cocaine with 140 mg Phendimetrazine | 10.7 units on a scale | Standard Error 5.7 |
| Phendimetrazine Dose Escalation | Peak Ratings of Nauseated/Queasy/Sick to Stomach on the Visual Analog Scale | 0 mg Cocaine with 210 mg Phendimetrazine | 5.2 units on a scale | Standard Error 4.14 |
| Phendimetrazine Dose Escalation | Peak Ratings of Nauseated/Queasy/Sick to Stomach on the Visual Analog Scale | 10 mg Cocaine with 210 mg Phendimetrazine | 1.7 units on a scale | Standard Error 1.25 |
| Phendimetrazine Dose Escalation | Peak Ratings of Nauseated/Queasy/Sick to Stomach on the Visual Analog Scale | 20 mg Cocaine with 210 mg Phendimetrazine | 4.8 units on a scale | Standard Error 2.83 |
| Phendimetrazine Dose Escalation | Peak Ratings of Nauseated/Queasy/Sick to Stomach on the Visual Analog Scale | 40 mg Cocaine with 210 mg Phendimetrazine | 4.3 units on a scale | Standard Error 2.54 |
| Phendimetrazine Dose Escalation | Peak Ratings of Nauseated/Queasy/Sick to Stomach on the Visual Analog Scale | 80 mg Cocaine with 210 mg Phendimetrazine | 2.9 units on a scale | Standard Error 1.89 |
Secondary
Peak Ratings of Nervous/Anxious on the Visual Analog Scale
Subjects rated their feelings of Nervous/Anxious on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.
Time frame: This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Phendimetrazine Dose Escalation | Peak Ratings of Nervous/Anxious on the Visual Analog Scale | 0 mg Cocaine with 0 mg Phendimetrazine | .7 units on a scale | Standard Error 0.47 |
| Phendimetrazine Dose Escalation | Peak Ratings of Nervous/Anxious on the Visual Analog Scale | 10 mg Cocaine with 0 mg Phendimetrazine | 2.3 units on a scale | Standard Error 1.12 |
| Phendimetrazine Dose Escalation | Peak Ratings of Nervous/Anxious on the Visual Analog Scale | 20 mg Cocaine with 0 mg Phendimetrazine | 3.7 units on a scale | Standard Error 2.27 |
| Phendimetrazine Dose Escalation | Peak Ratings of Nervous/Anxious on the Visual Analog Scale | 40 mg Cocaine with 0 mg Phendimetrazine | 4.1 units on a scale | Standard Error 2.61 |
| Phendimetrazine Dose Escalation | Peak Ratings of Nervous/Anxious on the Visual Analog Scale | 80 mg Cocaine with 0 mg Phendimetrazine | 9.4 units on a scale | Standard Error 6 |
| Phendimetrazine Dose Escalation | Peak Ratings of Nervous/Anxious on the Visual Analog Scale | 0 mg Cocaine with 70 mg Phendimetrazine | .6 units on a scale | Standard Error 0.43 |
| Phendimetrazine Dose Escalation | Peak Ratings of Nervous/Anxious on the Visual Analog Scale | 10 mg Cocaine with 70 mg Phendimetrazine | .9 units on a scale | Standard Error 0.53 |
| Phendimetrazine Dose Escalation | Peak Ratings of Nervous/Anxious on the Visual Analog Scale | 20 mg Cocaine with 70 mg Phendimetrazine | 2 units on a scale | Standard Error 1.14 |
| Phendimetrazine Dose Escalation | Peak Ratings of Nervous/Anxious on the Visual Analog Scale | 40 mg Cocaine with 70 mg Phendimetrazine | 5.4 units on a scale | Standard Error 2.5 |
| Phendimetrazine Dose Escalation | Peak Ratings of Nervous/Anxious on the Visual Analog Scale | 80 mg Cocaine with 70 mg Phendimetrazine | 7.7 units on a scale | Standard Error 4.46 |
| Phendimetrazine Dose Escalation | Peak Ratings of Nervous/Anxious on the Visual Analog Scale | 0 mg Cocaine with 140 mg Phendimetrazine | .5 units on a scale | Standard Error 0.4 |
| Phendimetrazine Dose Escalation | Peak Ratings of Nervous/Anxious on the Visual Analog Scale | 10 mg Cocaine with 140 mg Phendimetrazine | 1.7 units on a scale | Standard Error 0.75 |
| Phendimetrazine Dose Escalation | Peak Ratings of Nervous/Anxious on the Visual Analog Scale | 20 mg Cocaine with 140 mg Phendimetrazine | 2.5 units on a scale | Standard Error 1.24 |
| Phendimetrazine Dose Escalation | Peak Ratings of Nervous/Anxious on the Visual Analog Scale | 40 mg Cocaine with 140 mg Phendimetrazine | 6.7 units on a scale | Standard Error 2.96 |
| Phendimetrazine Dose Escalation | Peak Ratings of Nervous/Anxious on the Visual Analog Scale | 80 mg Cocaine with 140 mg Phendimetrazine | 10.5 units on a scale | Standard Error 4.22 |
| Phendimetrazine Dose Escalation | Peak Ratings of Nervous/Anxious on the Visual Analog Scale | 0 mg Cocaine with 210 mg Phendimetrazine | .8 units on a scale | Standard Error 0.55 |
| Phendimetrazine Dose Escalation | Peak Ratings of Nervous/Anxious on the Visual Analog Scale | 10 mg Cocaine with 210 mg Phendimetrazine | .5 units on a scale | Standard Error 0.4 |
| Phendimetrazine Dose Escalation | Peak Ratings of Nervous/Anxious on the Visual Analog Scale | 20 mg Cocaine with 210 mg Phendimetrazine | 3.7 units on a scale | Standard Error 2.13 |
| Phendimetrazine Dose Escalation | Peak Ratings of Nervous/Anxious on the Visual Analog Scale | 40 mg Cocaine with 210 mg Phendimetrazine | 4.4 units on a scale | Standard Error 2.28 |
| Phendimetrazine Dose Escalation | Peak Ratings of Nervous/Anxious on the Visual Analog Scale | 80 mg Cocaine with 210 mg Phendimetrazine | 10.1 units on a scale | Standard Error 6.52 |
Secondary
Peak Ratings of Performance Impaired on the Visual Analog Scale
Subjects rated their feelings of Performance Impaired on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.
Time frame: This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Phendimetrazine Dose Escalation | Peak Ratings of Performance Impaired on the Visual Analog Scale | 0 mg Cocaine with 0 mg Phendimetrazine | .8 units on a scale | Standard Error 0.7 |
| Phendimetrazine Dose Escalation | Peak Ratings of Performance Impaired on the Visual Analog Scale | 10 mg Cocaine with 0 mg Phendimetrazine | .7 units on a scale | Standard Error 0.47 |
| Phendimetrazine Dose Escalation | Peak Ratings of Performance Impaired on the Visual Analog Scale | 20 mg Cocaine with 0 mg Phendimetrazine | 1.9 units on a scale | Standard Error 0.98 |
| Phendimetrazine Dose Escalation | Peak Ratings of Performance Impaired on the Visual Analog Scale | 40 mg Cocaine with 0 mg Phendimetrazine | 3.3 units on a scale | Standard Error 1.24 |
| Phendimetrazine Dose Escalation | Peak Ratings of Performance Impaired on the Visual Analog Scale | 80 mg Cocaine with 0 mg Phendimetrazine | 3.4 units on a scale | Standard Error 1.31 |
| Phendimetrazine Dose Escalation | Peak Ratings of Performance Impaired on the Visual Analog Scale | 0 mg Cocaine with 70 mg Phendimetrazine | 1 units on a scale | Standard Error 0.68 |
| Phendimetrazine Dose Escalation | Peak Ratings of Performance Impaired on the Visual Analog Scale | 10 mg Cocaine with 70 mg Phendimetrazine | 2.2 units on a scale | Standard Error 1.12 |
| Phendimetrazine Dose Escalation | Peak Ratings of Performance Impaired on the Visual Analog Scale | 20 mg Cocaine with 70 mg Phendimetrazine | .8 units on a scale | Standard Error 0.55 |
| Phendimetrazine Dose Escalation | Peak Ratings of Performance Impaired on the Visual Analog Scale | 40 mg Cocaine with 70 mg Phendimetrazine | .7 units on a scale | Standard Error 0.6 |
| Phendimetrazine Dose Escalation | Peak Ratings of Performance Impaired on the Visual Analog Scale | 80 mg Cocaine with 70 mg Phendimetrazine | 4.9 units on a scale | Standard Error 2.82 |
| Phendimetrazine Dose Escalation | Peak Ratings of Performance Impaired on the Visual Analog Scale | 0 mg Cocaine with 140 mg Phendimetrazine | .8 units on a scale | Standard Error 0.42 |
| Phendimetrazine Dose Escalation | Peak Ratings of Performance Impaired on the Visual Analog Scale | 10 mg Cocaine with 140 mg Phendimetrazine | .7 units on a scale | Standard Error 0.47 |
| Phendimetrazine Dose Escalation | Peak Ratings of Performance Impaired on the Visual Analog Scale | 20 mg Cocaine with 140 mg Phendimetrazine | 4.5 units on a scale | Standard Error 3.56 |
| Phendimetrazine Dose Escalation | Peak Ratings of Performance Impaired on the Visual Analog Scale | 40 mg Cocaine with 140 mg Phendimetrazine | 2.1 units on a scale | Standard Error 1 |
| Phendimetrazine Dose Escalation | Peak Ratings of Performance Impaired on the Visual Analog Scale | 80 mg Cocaine with 140 mg Phendimetrazine | 3.7 units on a scale | Standard Error 1.78 |
| Phendimetrazine Dose Escalation | Peak Ratings of Performance Impaired on the Visual Analog Scale | 0 mg Cocaine with 210 mg Phendimetrazine | .8 units on a scale | Standard Error 0.55 |
| Phendimetrazine Dose Escalation | Peak Ratings of Performance Impaired on the Visual Analog Scale | 10 mg Cocaine with 210 mg Phendimetrazine | .3 units on a scale | Standard Error 0.3 |
| Phendimetrazine Dose Escalation | Peak Ratings of Performance Impaired on the Visual Analog Scale | 20 mg Cocaine with 210 mg Phendimetrazine | 7.6 units on a scale | Standard Error 5.07 |
| Phendimetrazine Dose Escalation | Peak Ratings of Performance Impaired on the Visual Analog Scale | 40 mg Cocaine with 210 mg Phendimetrazine | 4.4 units on a scale | Standard Error 3.65 |
| Phendimetrazine Dose Escalation | Peak Ratings of Performance Impaired on the Visual Analog Scale | 80 mg Cocaine with 210 mg Phendimetrazine | 7.6 units on a scale | Standard Error 5.24 |
Secondary
Peak Ratings of Performance Improved on the Visual Analog Scale
Subjects rated their feelings of Performance Improved on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.
Time frame: This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Phendimetrazine Dose Escalation | Peak Ratings of Performance Improved on the Visual Analog Scale | 0 mg Cocaine with 0 mg Phendimetrazine | .7 units on a scale | Standard Error 0.6 |
| Phendimetrazine Dose Escalation | Peak Ratings of Performance Improved on the Visual Analog Scale | 10 mg Cocaine with 0 mg Phendimetrazine | .7 units on a scale | Standard Error 0.42 |
| Phendimetrazine Dose Escalation | Peak Ratings of Performance Improved on the Visual Analog Scale | 20 mg Cocaine with 0 mg Phendimetrazine | 1.4 units on a scale | Standard Error 0.72 |
| Phendimetrazine Dose Escalation | Peak Ratings of Performance Improved on the Visual Analog Scale | 40 mg Cocaine with 0 mg Phendimetrazine | 1.4 units on a scale | Standard Error 0.6 |
| Phendimetrazine Dose Escalation | Peak Ratings of Performance Improved on the Visual Analog Scale | 80 mg Cocaine with 0 mg Phendimetrazine | 6.6 units on a scale | Standard Error 4.49 |
| Phendimetrazine Dose Escalation | Peak Ratings of Performance Improved on the Visual Analog Scale | 0 mg Cocaine with 70 mg Phendimetrazine | .7 units on a scale | Standard Error 0.6 |
| Phendimetrazine Dose Escalation | Peak Ratings of Performance Improved on the Visual Analog Scale | 10 mg Cocaine with 70 mg Phendimetrazine | .6 units on a scale | Standard Error 0.5 |
| Phendimetrazine Dose Escalation | Peak Ratings of Performance Improved on the Visual Analog Scale | 20 mg Cocaine with 70 mg Phendimetrazine | 1.9 units on a scale | Standard Error 0.91 |
| Phendimetrazine Dose Escalation | Peak Ratings of Performance Improved on the Visual Analog Scale | 40 mg Cocaine with 70 mg Phendimetrazine | 4.8 units on a scale | Standard Error 3.31 |
| Phendimetrazine Dose Escalation | Peak Ratings of Performance Improved on the Visual Analog Scale | 80 mg Cocaine with 70 mg Phendimetrazine | 2.4 units on a scale | Standard Error 1.15 |
| Phendimetrazine Dose Escalation | Peak Ratings of Performance Improved on the Visual Analog Scale | 0 mg Cocaine with 140 mg Phendimetrazine | .9 units on a scale | Standard Error 0.6 |
| Phendimetrazine Dose Escalation | Peak Ratings of Performance Improved on the Visual Analog Scale | 10 mg Cocaine with 140 mg Phendimetrazine | .9 units on a scale | Standard Error 0.6 |
| Phendimetrazine Dose Escalation | Peak Ratings of Performance Improved on the Visual Analog Scale | 20 mg Cocaine with 140 mg Phendimetrazine | .8 units on a scale | Standard Error 0.61 |
| Phendimetrazine Dose Escalation | Peak Ratings of Performance Improved on the Visual Analog Scale | 40 mg Cocaine with 140 mg Phendimetrazine | 3.6 units on a scale | Standard Error 2.84 |
| Phendimetrazine Dose Escalation | Peak Ratings of Performance Improved on the Visual Analog Scale | 80 mg Cocaine with 140 mg Phendimetrazine | 5.1 units on a scale | Standard Error 3.58 |
| Phendimetrazine Dose Escalation | Peak Ratings of Performance Improved on the Visual Analog Scale | 0 mg Cocaine with 210 mg Phendimetrazine | 1.9 units on a scale | Standard Error 1.29 |
| Phendimetrazine Dose Escalation | Peak Ratings of Performance Improved on the Visual Analog Scale | 10 mg Cocaine with 210 mg Phendimetrazine | .5 units on a scale | Standard Error 0.4 |
| Phendimetrazine Dose Escalation | Peak Ratings of Performance Improved on the Visual Analog Scale | 20 mg Cocaine with 210 mg Phendimetrazine | 1.6 units on a scale | Standard Error 1.06 |
| Phendimetrazine Dose Escalation | Peak Ratings of Performance Improved on the Visual Analog Scale | 40 mg Cocaine with 210 mg Phendimetrazine | 3.9 units on a scale | Standard Error 2.9 |
| Phendimetrazine Dose Escalation | Peak Ratings of Performance Improved on the Visual Analog Scale | 80 mg Cocaine with 210 mg Phendimetrazine | 2.6 units on a scale | Standard Error 1.65 |
Secondary
Peak Ratings of Restless on the Visual Analog Scale
Subjects rated their feelings of Restless on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.
Time frame: This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Phendimetrazine Dose Escalation | Peak Ratings of Restless on the Visual Analog Scale | 0 mg Cocaine with 0 mg Phendimetrazine | .5 units on a scale | Standard Error 0.4 |
| Phendimetrazine Dose Escalation | Peak Ratings of Restless on the Visual Analog Scale | 10 mg Cocaine with 0 mg Phendimetrazine | 1.9 units on a scale | Standard Error 1.08 |
| Phendimetrazine Dose Escalation | Peak Ratings of Restless on the Visual Analog Scale | 20 mg Cocaine with 0 mg Phendimetrazine | .7 units on a scale | Standard Error 0.6 |
| Phendimetrazine Dose Escalation | Peak Ratings of Restless on the Visual Analog Scale | 40 mg Cocaine with 0 mg Phendimetrazine | 1.8 units on a scale | Standard Error 1.01 |
| Phendimetrazine Dose Escalation | Peak Ratings of Restless on the Visual Analog Scale | 80 mg Cocaine with 0 mg Phendimetrazine | 2.3 units on a scale | Standard Error 1.32 |
| Phendimetrazine Dose Escalation | Peak Ratings of Restless on the Visual Analog Scale | 0 mg Cocaine with 70 mg Phendimetrazine | .5 units on a scale | Standard Error 0.5 |
| Phendimetrazine Dose Escalation | Peak Ratings of Restless on the Visual Analog Scale | 10 mg Cocaine with 70 mg Phendimetrazine | .9 units on a scale | Standard Error 0.53 |
| Phendimetrazine Dose Escalation | Peak Ratings of Restless on the Visual Analog Scale | 20 mg Cocaine with 70 mg Phendimetrazine | .7 units on a scale | Standard Error 0.47 |
| Phendimetrazine Dose Escalation | Peak Ratings of Restless on the Visual Analog Scale | 40 mg Cocaine with 70 mg Phendimetrazine | 1.1 units on a scale | Standard Error 0.64 |
| Phendimetrazine Dose Escalation | Peak Ratings of Restless on the Visual Analog Scale | 80 mg Cocaine with 70 mg Phendimetrazine | 1 units on a scale | Standard Error 0.54 |
| Phendimetrazine Dose Escalation | Peak Ratings of Restless on the Visual Analog Scale | 0 mg Cocaine with 140 mg Phendimetrazine | 1 units on a scale | Standard Error 0.68 |
| Phendimetrazine Dose Escalation | Peak Ratings of Restless on the Visual Analog Scale | 10 mg Cocaine with 140 mg Phendimetrazine | 1.8 units on a scale | Standard Error 0.9 |
| Phendimetrazine Dose Escalation | Peak Ratings of Restless on the Visual Analog Scale | 20 mg Cocaine with 140 mg Phendimetrazine | 2.3 units on a scale | Standard Error 1.67 |
| Phendimetrazine Dose Escalation | Peak Ratings of Restless on the Visual Analog Scale | 40 mg Cocaine with 140 mg Phendimetrazine | 4.1 units on a scale | Standard Error 1.96 |
| Phendimetrazine Dose Escalation | Peak Ratings of Restless on the Visual Analog Scale | 80 mg Cocaine with 140 mg Phendimetrazine | 4 units on a scale | Standard Error 2.04 |
| Phendimetrazine Dose Escalation | Peak Ratings of Restless on the Visual Analog Scale | 0 mg Cocaine with 210 mg Phendimetrazine | 1.6 units on a scale | Standard Error 0.99 |
| Phendimetrazine Dose Escalation | Peak Ratings of Restless on the Visual Analog Scale | 10 mg Cocaine with 210 mg Phendimetrazine | 2.7 units on a scale | Standard Error 2.28 |
| Phendimetrazine Dose Escalation | Peak Ratings of Restless on the Visual Analog Scale | 20 mg Cocaine with 210 mg Phendimetrazine | 2.0 units on a scale | Standard Error 1.61 |
| Phendimetrazine Dose Escalation | Peak Ratings of Restless on the Visual Analog Scale | 40 mg Cocaine with 210 mg Phendimetrazine | 3.6 units on a scale | Standard Error 1.59 |
| Phendimetrazine Dose Escalation | Peak Ratings of Restless on the Visual Analog Scale | 80 mg Cocaine with 210 mg Phendimetrazine | 6.9 units on a scale | Standard Error 5.38 |
Secondary
Peak Ratings of Rush on the Visual Analog Scale
Subjects rated their feelings of Rush on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.
Time frame: This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Phendimetrazine Dose Escalation | Peak Ratings of Rush on the Visual Analog Scale | 0 mg Cocaine with 0 mg Phendimetrazine | .5 units on a scale | Standard Error 0.5 |
| Phendimetrazine Dose Escalation | Peak Ratings of Rush on the Visual Analog Scale | 10 mg Cocaine with 0 mg Phendimetrazine | 4.4 units on a scale | Standard Error 2.4 |
| Phendimetrazine Dose Escalation | Peak Ratings of Rush on the Visual Analog Scale | 20 mg Cocaine with 0 mg Phendimetrazine | 11.9 units on a scale | Standard Error 4.53 |
| Phendimetrazine Dose Escalation | Peak Ratings of Rush on the Visual Analog Scale | 40 mg Cocaine with 0 mg Phendimetrazine | 11.4 units on a scale | Standard Error 5.93 |
| Phendimetrazine Dose Escalation | Peak Ratings of Rush on the Visual Analog Scale | 80 mg Cocaine with 0 mg Phendimetrazine | 17.4 units on a scale | Standard Error 7.06 |
| Phendimetrazine Dose Escalation | Peak Ratings of Rush on the Visual Analog Scale | 0 mg Cocaine with 70 mg Phendimetrazine | .9 units on a scale | Standard Error 0.6 |
| Phendimetrazine Dose Escalation | Peak Ratings of Rush on the Visual Analog Scale | 10 mg Cocaine with 70 mg Phendimetrazine | 3.4 units on a scale | Standard Error 1.5 |
| Phendimetrazine Dose Escalation | Peak Ratings of Rush on the Visual Analog Scale | 20 mg Cocaine with 70 mg Phendimetrazine | 8 units on a scale | Standard Error 3.73 |
| Phendimetrazine Dose Escalation | Peak Ratings of Rush on the Visual Analog Scale | 40 mg Cocaine with 70 mg Phendimetrazine | 11.1 units on a scale | Standard Error 4.32 |
| Phendimetrazine Dose Escalation | Peak Ratings of Rush on the Visual Analog Scale | 80 mg Cocaine with 70 mg Phendimetrazine | 20 units on a scale | Standard Error 7.11 |
| Phendimetrazine Dose Escalation | Peak Ratings of Rush on the Visual Analog Scale | 0 mg Cocaine with 140 mg Phendimetrazine | 1 units on a scale | Standard Error 0.67 |
| Phendimetrazine Dose Escalation | Peak Ratings of Rush on the Visual Analog Scale | 10 mg Cocaine with 140 mg Phendimetrazine | 5.67 units on a scale | Standard Error 2.12 |
| Phendimetrazine Dose Escalation | Peak Ratings of Rush on the Visual Analog Scale | 20 mg Cocaine with 140 mg Phendimetrazine | 9.2 units on a scale | Standard Error 3.44 |
| Phendimetrazine Dose Escalation | Peak Ratings of Rush on the Visual Analog Scale | 40 mg Cocaine with 140 mg Phendimetrazine | 16.3 units on a scale | Standard Error 5.95 |
| Phendimetrazine Dose Escalation | Peak Ratings of Rush on the Visual Analog Scale | 80 mg Cocaine with 140 mg Phendimetrazine | 21.8 units on a scale | Standard Error 6.03 |
| Phendimetrazine Dose Escalation | Peak Ratings of Rush on the Visual Analog Scale | 0 mg Cocaine with 210 mg Phendimetrazine | 1.4 units on a scale | Standard Error 0.86 |
| Phendimetrazine Dose Escalation | Peak Ratings of Rush on the Visual Analog Scale | 10 mg Cocaine with 210 mg Phendimetrazine | 7.3 units on a scale | Standard Error 2.49 |
| Phendimetrazine Dose Escalation | Peak Ratings of Rush on the Visual Analog Scale | 20 mg Cocaine with 210 mg Phendimetrazine | 10.3 units on a scale | Standard Error 3.62 |
| Phendimetrazine Dose Escalation | Peak Ratings of Rush on the Visual Analog Scale | 40 mg Cocaine with 210 mg Phendimetrazine | 13.2 units on a scale | Standard Error 4.55 |
| Phendimetrazine Dose Escalation | Peak Ratings of Rush on the Visual Analog Scale | 80 mg Cocaine with 210 mg Phendimetrazine | 16.9 units on a scale | Standard Error 5.58 |
Secondary
Peak Ratings of Shaky/Jittery on the Visual Analog Scale
Subjects rated their feelings of Shaky/Jittery on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.
Time frame: This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Phendimetrazine Dose Escalation | Peak Ratings of Shaky/Jittery on the Visual Analog Scale | 0 mg Cocaine with 0 mg Phendimetrazine | 1.7 units on a scale | Standard Error 0.88 |
| Phendimetrazine Dose Escalation | Peak Ratings of Shaky/Jittery on the Visual Analog Scale | 10 mg Cocaine with 0 mg Phendimetrazine | 1.8 units on a scale | Standard Error 0.88 |
| Phendimetrazine Dose Escalation | Peak Ratings of Shaky/Jittery on the Visual Analog Scale | 20 mg Cocaine with 0 mg Phendimetrazine | 6.1 units on a scale | Standard Error 3.14 |
| Phendimetrazine Dose Escalation | Peak Ratings of Shaky/Jittery on the Visual Analog Scale | 40 mg Cocaine with 0 mg Phendimetrazine | 6 units on a scale | Standard Error 3.78 |
| Phendimetrazine Dose Escalation | Peak Ratings of Shaky/Jittery on the Visual Analog Scale | 80 mg Cocaine with 0 mg Phendimetrazine | 11.9 units on a scale | Standard Error 7.28 |
| Phendimetrazine Dose Escalation | Peak Ratings of Shaky/Jittery on the Visual Analog Scale | 0 mg Cocaine with 70 mg Phendimetrazine | .4 units on a scale | Standard Error 0.4 |
| Phendimetrazine Dose Escalation | Peak Ratings of Shaky/Jittery on the Visual Analog Scale | 10 mg Cocaine with 70 mg Phendimetrazine | .5 units on a scale | Standard Error 0.5 |
| Phendimetrazine Dose Escalation | Peak Ratings of Shaky/Jittery on the Visual Analog Scale | 20 mg Cocaine with 70 mg Phendimetrazine | 1.8 units on a scale | Standard Error 1.05 |
| Phendimetrazine Dose Escalation | Peak Ratings of Shaky/Jittery on the Visual Analog Scale | 40 mg Cocaine with 70 mg Phendimetrazine | 2.4 units on a scale | Standard Error 1.61 |
| Phendimetrazine Dose Escalation | Peak Ratings of Shaky/Jittery on the Visual Analog Scale | 80 mg Cocaine with 70 mg Phendimetrazine | 6.5 units on a scale | Standard Error 3.39 |
| Phendimetrazine Dose Escalation | Peak Ratings of Shaky/Jittery on the Visual Analog Scale | 0 mg Cocaine with 140 mg Phendimetrazine | 1.4 units on a scale | Standard Error 0.79 |
| Phendimetrazine Dose Escalation | Peak Ratings of Shaky/Jittery on the Visual Analog Scale | 10 mg Cocaine with 140 mg Phendimetrazine | .9 units on a scale | Standard Error 0.6 |
| Phendimetrazine Dose Escalation | Peak Ratings of Shaky/Jittery on the Visual Analog Scale | 20 mg Cocaine with 140 mg Phendimetrazine | 3.8 units on a scale | Standard Error 1.7 |
| Phendimetrazine Dose Escalation | Peak Ratings of Shaky/Jittery on the Visual Analog Scale | 40 mg Cocaine with 140 mg Phendimetrazine | 3.9 units on a scale | Standard Error 2.3 |
| Phendimetrazine Dose Escalation | Peak Ratings of Shaky/Jittery on the Visual Analog Scale | 80 mg Cocaine with 140 mg Phendimetrazine | 12.8 units on a scale | Standard Error 5.33 |
| Phendimetrazine Dose Escalation | Peak Ratings of Shaky/Jittery on the Visual Analog Scale | 0 mg Cocaine with 210 mg Phendimetrazine | .3 units on a scale | Standard Error 0.3 |
| Phendimetrazine Dose Escalation | Peak Ratings of Shaky/Jittery on the Visual Analog Scale | 10 mg Cocaine with 210 mg Phendimetrazine | .8 units on a scale | Standard Error 0.55 |
| Phendimetrazine Dose Escalation | Peak Ratings of Shaky/Jittery on the Visual Analog Scale | 20 mg Cocaine with 210 mg Phendimetrazine | 1.9 units on a scale | Standard Error 1.04 |
| Phendimetrazine Dose Escalation | Peak Ratings of Shaky/Jittery on the Visual Analog Scale | 40 mg Cocaine with 210 mg Phendimetrazine | 6.6 units on a scale | Standard Error 2.92 |
| Phendimetrazine Dose Escalation | Peak Ratings of Shaky/Jittery on the Visual Analog Scale | 80 mg Cocaine with 210 mg Phendimetrazine | 9 units on a scale | Standard Error 5.58 |
Secondary
Peak Ratings of Sluggish/Fatigued/Lazy on the Visual Analog Scale
Subjects rated their feelings of Sluggish/Fatigued/Lazy on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.
Time frame: This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Phendimetrazine Dose Escalation | Peak Ratings of Sluggish/Fatigued/Lazy on the Visual Analog Scale | 0 mg Cocaine with 0 mg Phendimetrazine | 1.7 units on a scale | Standard Error 0.9 |
| Phendimetrazine Dose Escalation | Peak Ratings of Sluggish/Fatigued/Lazy on the Visual Analog Scale | 10 mg Cocaine with 0 mg Phendimetrazine | 1.8 units on a scale | Standard Error 1.09 |
| Phendimetrazine Dose Escalation | Peak Ratings of Sluggish/Fatigued/Lazy on the Visual Analog Scale | 20 mg Cocaine with 0 mg Phendimetrazine | 1.09 units on a scale | Standard Error 1 |
| Phendimetrazine Dose Escalation | Peak Ratings of Sluggish/Fatigued/Lazy on the Visual Analog Scale | 40 mg Cocaine with 0 mg Phendimetrazine | 3.3 units on a scale | Standard Error 1.81 |
| Phendimetrazine Dose Escalation | Peak Ratings of Sluggish/Fatigued/Lazy on the Visual Analog Scale | 80 mg Cocaine with 0 mg Phendimetrazine | 8.5 units on a scale | Standard Error 5.85 |
| Phendimetrazine Dose Escalation | Peak Ratings of Sluggish/Fatigued/Lazy on the Visual Analog Scale | 0 mg Cocaine with 70 mg Phendimetrazine | .6 units on a scale | Standard Error 0.43 |
| Phendimetrazine Dose Escalation | Peak Ratings of Sluggish/Fatigued/Lazy on the Visual Analog Scale | 10 mg Cocaine with 70 mg Phendimetrazine | 3.0 units on a scale | Standard Error 1.96 |
| Phendimetrazine Dose Escalation | Peak Ratings of Sluggish/Fatigued/Lazy on the Visual Analog Scale | 20 mg Cocaine with 70 mg Phendimetrazine | 3.3 units on a scale | Standard Error 2.47 |
| Phendimetrazine Dose Escalation | Peak Ratings of Sluggish/Fatigued/Lazy on the Visual Analog Scale | 40 mg Cocaine with 70 mg Phendimetrazine | 5.3 units on a scale | Standard Error 3.53 |
| Phendimetrazine Dose Escalation | Peak Ratings of Sluggish/Fatigued/Lazy on the Visual Analog Scale | 80 mg Cocaine with 70 mg Phendimetrazine | 6 units on a scale | Standard Error 3.53 |
| Phendimetrazine Dose Escalation | Peak Ratings of Sluggish/Fatigued/Lazy on the Visual Analog Scale | 0 mg Cocaine with 140 mg Phendimetrazine | .7 units on a scale | Standard Error 0.4 |
| Phendimetrazine Dose Escalation | Peak Ratings of Sluggish/Fatigued/Lazy on the Visual Analog Scale | 10 mg Cocaine with 140 mg Phendimetrazine | 4.8 units on a scale | Standard Error 2.27 |
| Phendimetrazine Dose Escalation | Peak Ratings of Sluggish/Fatigued/Lazy on the Visual Analog Scale | 20 mg Cocaine with 140 mg Phendimetrazine | 4.6 units on a scale | Standard Error 2.47 |
| Phendimetrazine Dose Escalation | Peak Ratings of Sluggish/Fatigued/Lazy on the Visual Analog Scale | 40 mg Cocaine with 140 mg Phendimetrazine | 5.3 units on a scale | Standard Error 2.94 |
| Phendimetrazine Dose Escalation | Peak Ratings of Sluggish/Fatigued/Lazy on the Visual Analog Scale | 80 mg Cocaine with 140 mg Phendimetrazine | 10.9 units on a scale | Standard Error 5.49 |
| Phendimetrazine Dose Escalation | Peak Ratings of Sluggish/Fatigued/Lazy on the Visual Analog Scale | 0 mg Cocaine with 210 mg Phendimetrazine | 7 units on a scale | Standard Error 5.82 |
| Phendimetrazine Dose Escalation | Peak Ratings of Sluggish/Fatigued/Lazy on the Visual Analog Scale | 10 mg Cocaine with 210 mg Phendimetrazine | 5.5 units on a scale | Standard Error 2.67 |
| Phendimetrazine Dose Escalation | Peak Ratings of Sluggish/Fatigued/Lazy on the Visual Analog Scale | 20 mg Cocaine with 210 mg Phendimetrazine | 4.8 units on a scale | Standard Error 2.64 |
| Phendimetrazine Dose Escalation | Peak Ratings of Sluggish/Fatigued/Lazy on the Visual Analog Scale | 40 mg Cocaine with 210 mg Phendimetrazine | 4.2 units on a scale | Standard Error 2.63 |
| Phendimetrazine Dose Escalation | Peak Ratings of Sluggish/Fatigued/Lazy on the Visual Analog Scale | 80 mg Cocaine with 210 mg Phendimetrazine | 8.8 units on a scale | Standard Error 7.16 |
Secondary
Peak Ratings of Stimulated on the Visual Analog Scale
Subjects rated their feelings of Stimulated on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.
Time frame: This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Phendimetrazine Dose Escalation | Peak Ratings of Stimulated on the Visual Analog Scale | 20 mg Cocaine with 0 mg Phendimetrazine | 5.6 units on a scale | Standard Error 2.9 |
| Phendimetrazine Dose Escalation | Peak Ratings of Stimulated on the Visual Analog Scale | 40 mg Cocaine with 0 mg Phendimetrazine | 5.1 units on a scale | Standard Error 2.56 |
| Phendimetrazine Dose Escalation | Peak Ratings of Stimulated on the Visual Analog Scale | 0 mg Cocaine with 0 mg Phendimetrazine | 1.8 units on a scale | Standard Error 0.8 |
| Phendimetrazine Dose Escalation | Peak Ratings of Stimulated on the Visual Analog Scale | 10 mg Cocaine with 0 mg Phendimetrazine | 2 units on a scale | Standard Error 0.93 |
| Phendimetrazine Dose Escalation | Peak Ratings of Stimulated on the Visual Analog Scale | 80 mg Cocaine with 0 mg Phendimetrazine | 10.8 units on a scale | Standard Error 4.92 |
| Phendimetrazine Dose Escalation | Peak Ratings of Stimulated on the Visual Analog Scale | 0 mg Cocaine with 70 mg Phendimetrazine | .8 units on a scale | Standard Error 0.53 |
| Phendimetrazine Dose Escalation | Peak Ratings of Stimulated on the Visual Analog Scale | 10 mg Cocaine with 70 mg Phendimetrazine | 3.7 units on a scale | Standard Error 1.55 |
| Phendimetrazine Dose Escalation | Peak Ratings of Stimulated on the Visual Analog Scale | 20 mg Cocaine with 70 mg Phendimetrazine | 4.9 units on a scale | Standard Error 2.61 |
| Phendimetrazine Dose Escalation | Peak Ratings of Stimulated on the Visual Analog Scale | 40 mg Cocaine with 70 mg Phendimetrazine | 8.9 units on a scale | Standard Error 4.42 |
| Phendimetrazine Dose Escalation | Peak Ratings of Stimulated on the Visual Analog Scale | 80 mg Cocaine with 70 mg Phendimetrazine | 12.4 units on a scale | Standard Error 4.53 |
| Phendimetrazine Dose Escalation | Peak Ratings of Stimulated on the Visual Analog Scale | 0 mg Cocaine with 140 mg Phendimetrazine | 1.6 units on a scale | Standard Error 0.82 |
| Phendimetrazine Dose Escalation | Peak Ratings of Stimulated on the Visual Analog Scale | 10 mg Cocaine with 140 mg Phendimetrazine | 2.9 units on a scale | Standard Error 1.28 |
| Phendimetrazine Dose Escalation | Peak Ratings of Stimulated on the Visual Analog Scale | 20 mg Cocaine with 140 mg Phendimetrazine | 5.5 units on a scale | Standard Error 3.59 |
| Phendimetrazine Dose Escalation | Peak Ratings of Stimulated on the Visual Analog Scale | 40 mg Cocaine with 140 mg Phendimetrazine | 11.6 units on a scale | Standard Error 5.36 |
| Phendimetrazine Dose Escalation | Peak Ratings of Stimulated on the Visual Analog Scale | 80 mg Cocaine with 140 mg Phendimetrazine | 10.9 units on a scale | Standard Error 5.12 |
| Phendimetrazine Dose Escalation | Peak Ratings of Stimulated on the Visual Analog Scale | 0 mg Cocaine with 210 mg Phendimetrazine | 2.2 units on a scale | Standard Error 1.14 |
| Phendimetrazine Dose Escalation | Peak Ratings of Stimulated on the Visual Analog Scale | 10 mg Cocaine with 210 mg Phendimetrazine | 2.4 units on a scale | Standard Error 1.56 |
| Phendimetrazine Dose Escalation | Peak Ratings of Stimulated on the Visual Analog Scale | 20 mg Cocaine with 210 mg Phendimetrazine | 4.8 units on a scale | Standard Error 2.45 |
| Phendimetrazine Dose Escalation | Peak Ratings of Stimulated on the Visual Analog Scale | 40 mg Cocaine with 210 mg Phendimetrazine | 9.1 units on a scale | Standard Error 3.52 |
| Phendimetrazine Dose Escalation | Peak Ratings of Stimulated on the Visual Analog Scale | 80 mg Cocaine with 210 mg Phendimetrazine | 14.7 units on a scale | Standard Error 6.91 |
Secondary
Peak Ratings of Talkative/Friendly on the Visual Analog Scale
Subjects rated their feelings of Talkative/Friendly on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.
Time frame: This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Phendimetrazine Dose Escalation | Peak Ratings of Talkative/Friendly on the Visual Analog Scale | 0 mg Cocaine with 140 mg Phendimetrazine | 1 units on a scale | Standard Error 0.68 |
| Phendimetrazine Dose Escalation | Peak Ratings of Talkative/Friendly on the Visual Analog Scale | 0 mg Cocaine with 0 mg Phendimetrazine | 1 units on a scale | Standard Error 0.6 |
| Phendimetrazine Dose Escalation | Peak Ratings of Talkative/Friendly on the Visual Analog Scale | 10 mg Cocaine with 0 mg Phendimetrazine | 2.7 units on a scale | Standard Error 1.28 |
| Phendimetrazine Dose Escalation | Peak Ratings of Talkative/Friendly on the Visual Analog Scale | 20 mg Cocaine with 0 mg Phendimetrazine | 3.9 units on a scale | Standard Error 2.96 |
| Phendimetrazine Dose Escalation | Peak Ratings of Talkative/Friendly on the Visual Analog Scale | 40 mg Cocaine with 0 mg Phendimetrazine | 3.5 units on a scale | Standard Error 2.4 |
| Phendimetrazine Dose Escalation | Peak Ratings of Talkative/Friendly on the Visual Analog Scale | 80 mg Cocaine with 0 mg Phendimetrazine | 4.3 units on a scale | Standard Error 2.82 |
| Phendimetrazine Dose Escalation | Peak Ratings of Talkative/Friendly on the Visual Analog Scale | 0 mg Cocaine with 70 mg Phendimetrazine | .6 units on a scale | Standard Error 0.6 |
| Phendimetrazine Dose Escalation | Peak Ratings of Talkative/Friendly on the Visual Analog Scale | 10 mg Cocaine with 70 mg Phendimetrazine | 2.7 units on a scale | Standard Error 1.21 |
| Phendimetrazine Dose Escalation | Peak Ratings of Talkative/Friendly on the Visual Analog Scale | 20 mg Cocaine with 70 mg Phendimetrazine | 5.4 units on a scale | Standard Error 2.63 |
| Phendimetrazine Dose Escalation | Peak Ratings of Talkative/Friendly on the Visual Analog Scale | 40 mg Cocaine with 70 mg Phendimetrazine | 7.3 units on a scale | Standard Error 3.09 |
| Phendimetrazine Dose Escalation | Peak Ratings of Talkative/Friendly on the Visual Analog Scale | 80 mg Cocaine with 70 mg Phendimetrazine | 8 units on a scale | Standard Error 3.87 |
| Phendimetrazine Dose Escalation | Peak Ratings of Talkative/Friendly on the Visual Analog Scale | 10 mg Cocaine with 140 mg Phendimetrazine | 1.2 units on a scale | Standard Error 0.81 |
| Phendimetrazine Dose Escalation | Peak Ratings of Talkative/Friendly on the Visual Analog Scale | 20 mg Cocaine with 140 mg Phendimetrazine | 1.9 units on a scale | Standard Error 1.04 |
| Phendimetrazine Dose Escalation | Peak Ratings of Talkative/Friendly on the Visual Analog Scale | 40 mg Cocaine with 140 mg Phendimetrazine | 3.2 units on a scale | Standard Error 1.65 |
| Phendimetrazine Dose Escalation | Peak Ratings of Talkative/Friendly on the Visual Analog Scale | 80 mg Cocaine with 140 mg Phendimetrazine | 7.2 units on a scale | Standard Error 2.74 |
| Phendimetrazine Dose Escalation | Peak Ratings of Talkative/Friendly on the Visual Analog Scale | 0 mg Cocaine with 210 mg Phendimetrazine | .7 units on a scale | Standard Error 0.47 |
| Phendimetrazine Dose Escalation | Peak Ratings of Talkative/Friendly on the Visual Analog Scale | 10 mg Cocaine with 210 mg Phendimetrazine | .5 units on a scale | Standard Error 0.34 |
| Phendimetrazine Dose Escalation | Peak Ratings of Talkative/Friendly on the Visual Analog Scale | 20 mg Cocaine with 210 mg Phendimetrazine | 1.9 units on a scale | Standard Error 0.92 |
| Phendimetrazine Dose Escalation | Peak Ratings of Talkative/Friendly on the Visual Analog Scale | 40 mg Cocaine with 210 mg Phendimetrazine | 1.7 units on a scale | Standard Error 1.11 |
| Phendimetrazine Dose Escalation | Peak Ratings of Talkative/Friendly on the Visual Analog Scale | 80 mg Cocaine with 210 mg Phendimetrazine | 3.4 units on a scale | Standard Error 1.43 |
Secondary
Peak Ratings of Willing to Pay For on the Visual Analog Scale
Subjects rated their feelings of Willing to Pay For on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.
Time frame: This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Phendimetrazine Dose Escalation | Peak Ratings of Willing to Pay For on the Visual Analog Scale | 0 mg Cocaine with 0 mg Phendimetrazine | .9 units on a scale | Standard Error 0.9 |
| Phendimetrazine Dose Escalation | Peak Ratings of Willing to Pay For on the Visual Analog Scale | 10 mg Cocaine with 0 mg Phendimetrazine | 4.4 units on a scale | Standard Error 2.49 |
| Phendimetrazine Dose Escalation | Peak Ratings of Willing to Pay For on the Visual Analog Scale | 20 mg Cocaine with 0 mg Phendimetrazine | 8.2 units on a scale | Standard Error 3.53 |
| Phendimetrazine Dose Escalation | Peak Ratings of Willing to Pay For on the Visual Analog Scale | 40 mg Cocaine with 0 mg Phendimetrazine | 11.2 units on a scale | Standard Error 4.59 |
| Phendimetrazine Dose Escalation | Peak Ratings of Willing to Pay For on the Visual Analog Scale | 80 mg Cocaine with 0 mg Phendimetrazine | 20.2 units on a scale | Standard Error 7.01 |
| Phendimetrazine Dose Escalation | Peak Ratings of Willing to Pay For on the Visual Analog Scale | 0 mg Cocaine with 70 mg Phendimetrazine | 1.1 units on a scale | Standard Error 0.72 |
| Phendimetrazine Dose Escalation | Peak Ratings of Willing to Pay For on the Visual Analog Scale | 10 mg Cocaine with 70 mg Phendimetrazine | 1.4 units on a scale | Standard Error 0.86 |
| Phendimetrazine Dose Escalation | Peak Ratings of Willing to Pay For on the Visual Analog Scale | 20 mg Cocaine with 70 mg Phendimetrazine | 6.4 units on a scale | Standard Error 2.9 |
| Phendimetrazine Dose Escalation | Peak Ratings of Willing to Pay For on the Visual Analog Scale | 40 mg Cocaine with 70 mg Phendimetrazine | 14.1 units on a scale | Standard Error 4.62 |
| Phendimetrazine Dose Escalation | Peak Ratings of Willing to Pay For on the Visual Analog Scale | 80 mg Cocaine with 70 mg Phendimetrazine | 19.3 units on a scale | Standard Error 5.63 |
| Phendimetrazine Dose Escalation | Peak Ratings of Willing to Pay For on the Visual Analog Scale | 0 mg Cocaine with 140 mg Phendimetrazine | .8 units on a scale | Standard Error 0.42 |
| Phendimetrazine Dose Escalation | Peak Ratings of Willing to Pay For on the Visual Analog Scale | 10 mg Cocaine with 140 mg Phendimetrazine | 3.2 units on a scale | Standard Error 2.15 |
| Phendimetrazine Dose Escalation | Peak Ratings of Willing to Pay For on the Visual Analog Scale | 20 mg Cocaine with 140 mg Phendimetrazine | 7.9 units on a scale | Standard Error 3.82 |
| Phendimetrazine Dose Escalation | Peak Ratings of Willing to Pay For on the Visual Analog Scale | 40 mg Cocaine with 140 mg Phendimetrazine | 18.3 units on a scale | Standard Error 6.58 |
| Phendimetrazine Dose Escalation | Peak Ratings of Willing to Pay For on the Visual Analog Scale | 80 mg Cocaine with 140 mg Phendimetrazine | 23 units on a scale | Standard Error 5.77 |
| Phendimetrazine Dose Escalation | Peak Ratings of Willing to Pay For on the Visual Analog Scale | 0 mg Cocaine with 210 mg Phendimetrazine | 1.7 units on a scale | Standard Error 1.32 |
| Phendimetrazine Dose Escalation | Peak Ratings of Willing to Pay For on the Visual Analog Scale | 10 mg Cocaine with 210 mg Phendimetrazine | 6 units on a scale | Standard Error 2.65 |
| Phendimetrazine Dose Escalation | Peak Ratings of Willing to Pay For on the Visual Analog Scale | 20 mg Cocaine with 210 mg Phendimetrazine | 8.9 units on a scale | Standard Error 4.39 |
| Phendimetrazine Dose Escalation | Peak Ratings of Willing to Pay For on the Visual Analog Scale | 40 mg Cocaine with 210 mg Phendimetrazine | 12.3 units on a scale | Standard Error 3.77 |
| Phendimetrazine Dose Escalation | Peak Ratings of Willing to Pay For on the Visual Analog Scale | 80 mg Cocaine with 210 mg Phendimetrazine | 23.1 units on a scale | Standard Error 9.27 |
Secondary
Peak Ratings of Willing to Take Again on the Visual Analog Scale
Subjects rated their feelings of Willing to Take Again on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.
Time frame: This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Phendimetrazine Dose Escalation | Peak Ratings of Willing to Take Again on the Visual Analog Scale | 0 mg Cocaine with 0 mg Phendimetrazine | 1.1 units on a scale | Standard Error 0.66 |
| Phendimetrazine Dose Escalation | Peak Ratings of Willing to Take Again on the Visual Analog Scale | 10 mg Cocaine with 0 mg Phendimetrazine | 9.8 units on a scale | Standard Error 5.13 |
| Phendimetrazine Dose Escalation | Peak Ratings of Willing to Take Again on the Visual Analog Scale | 20 mg Cocaine with 0 mg Phendimetrazine | 14.1 units on a scale | Standard Error 5.44 |
| Phendimetrazine Dose Escalation | Peak Ratings of Willing to Take Again on the Visual Analog Scale | 40 mg Cocaine with 0 mg Phendimetrazine | 16.5 units on a scale | Standard Error 7.26 |
| Phendimetrazine Dose Escalation | Peak Ratings of Willing to Take Again on the Visual Analog Scale | 80 mg Cocaine with 0 mg Phendimetrazine | 22.9 units on a scale | Standard Error 8.82 |
| Phendimetrazine Dose Escalation | Peak Ratings of Willing to Take Again on the Visual Analog Scale | 0 mg Cocaine with 70 mg Phendimetrazine | 1.5 units on a scale | Standard Error 0.89 |
| Phendimetrazine Dose Escalation | Peak Ratings of Willing to Take Again on the Visual Analog Scale | 10 mg Cocaine with 70 mg Phendimetrazine | 3.5 units on a scale | Standard Error 0.96 |
| Phendimetrazine Dose Escalation | Peak Ratings of Willing to Take Again on the Visual Analog Scale | 20 mg Cocaine with 70 mg Phendimetrazine | 13 units on a scale | Standard Error 3.86 |
| Phendimetrazine Dose Escalation | Peak Ratings of Willing to Take Again on the Visual Analog Scale | 40 mg Cocaine with 70 mg Phendimetrazine | 20.7 units on a scale | Standard Error 5.96 |
| Phendimetrazine Dose Escalation | Peak Ratings of Willing to Take Again on the Visual Analog Scale | 80 mg Cocaine with 70 mg Phendimetrazine | 26.7 units on a scale | Standard Error 7.53 |
| Phendimetrazine Dose Escalation | Peak Ratings of Willing to Take Again on the Visual Analog Scale | 0 mg Cocaine with 140 mg Phendimetrazine | 1 units on a scale | Standard Error 0.63 |
| Phendimetrazine Dose Escalation | Peak Ratings of Willing to Take Again on the Visual Analog Scale | 10 mg Cocaine with 140 mg Phendimetrazine | 8.8 units on a scale | Standard Error 4.12 |
| Phendimetrazine Dose Escalation | Peak Ratings of Willing to Take Again on the Visual Analog Scale | 20 mg Cocaine with 140 mg Phendimetrazine | 11.1 units on a scale | Standard Error 4.8 |
| Phendimetrazine Dose Escalation | Peak Ratings of Willing to Take Again on the Visual Analog Scale | 40 mg Cocaine with 140 mg Phendimetrazine | 19.4 units on a scale | Standard Error 5.81 |
| Phendimetrazine Dose Escalation | Peak Ratings of Willing to Take Again on the Visual Analog Scale | 80 mg Cocaine with 140 mg Phendimetrazine | 25.8 units on a scale | Standard Error 5.2 |
| Phendimetrazine Dose Escalation | Peak Ratings of Willing to Take Again on the Visual Analog Scale | 0 mg Cocaine with 210 mg Phendimetrazine | 2 units on a scale | Standard Error 1.32 |
| Phendimetrazine Dose Escalation | Peak Ratings of Willing to Take Again on the Visual Analog Scale | 10 mg Cocaine with 210 mg Phendimetrazine | 11.2 units on a scale | Standard Error 5.2 |
| Phendimetrazine Dose Escalation | Peak Ratings of Willing to Take Again on the Visual Analog Scale | 20 mg Cocaine with 210 mg Phendimetrazine | 11.6 units on a scale | Standard Error 4.69 |
| Phendimetrazine Dose Escalation | Peak Ratings of Willing to Take Again on the Visual Analog Scale | 40 mg Cocaine with 210 mg Phendimetrazine | 17.9 units on a scale | Standard Error 5.15 |
| Phendimetrazine Dose Escalation | Peak Ratings of Willing to Take Again on the Visual Analog Scale | 80 mg Cocaine with 210 mg Phendimetrazine | 30 units on a scale | Standard Error 8.78 |
Secondary
Peak Score on Sedative Subscale of the Adjective Rating Scale
Subjects completed 16 items that loaded into the Sedative Subscale of the Adjective Rating Scale. The items were rated 0-4 on a Likert-type scale and the sum for the 16 sedative items was summed to yield the Sedative Subscale score. The maximum score for this scale was 64, the minimum was 0. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.
Time frame: This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Phendimetrazine Dose Escalation | Peak Score on Sedative Subscale of the Adjective Rating Scale | 0 mg Cocaine with 0 mg Phendimetrazine | 2.3 units on a scale | Standard Error 0.68 |
| Phendimetrazine Dose Escalation | Peak Score on Sedative Subscale of the Adjective Rating Scale | 10 mg Cocaine with 0 mg Phendimetrazine | 2.5 units on a scale | Standard Error 0.96 |
| Phendimetrazine Dose Escalation | Peak Score on Sedative Subscale of the Adjective Rating Scale | 20 mg Cocaine with 0 mg Phendimetrazine | 2.5 units on a scale | Standard Error 0.99 |
| Phendimetrazine Dose Escalation | Peak Score on Sedative Subscale of the Adjective Rating Scale | 40 mg Cocaine with 0 mg Phendimetrazine | 2.4 units on a scale | Standard Error 0.82 |
| Phendimetrazine Dose Escalation | Peak Score on Sedative Subscale of the Adjective Rating Scale | 80 mg Cocaine with 0 mg Phendimetrazine | 4.4 units on a scale | Standard Error 1.54 |
| Phendimetrazine Dose Escalation | Peak Score on Sedative Subscale of the Adjective Rating Scale | 0 mg Cocaine with 70 mg Phendimetrazine | 1.9 units on a scale | Standard Error 0.59 |
| Phendimetrazine Dose Escalation | Peak Score on Sedative Subscale of the Adjective Rating Scale | 10 mg Cocaine with 70 mg Phendimetrazine | 2.2 units on a scale | Standard Error 1.03 |
| Phendimetrazine Dose Escalation | Peak Score on Sedative Subscale of the Adjective Rating Scale | 20 mg Cocaine with 70 mg Phendimetrazine | 3.5 units on a scale | Standard Error 1.65 |
| Phendimetrazine Dose Escalation | Peak Score on Sedative Subscale of the Adjective Rating Scale | 40 mg Cocaine with 70 mg Phendimetrazine | 4.2 units on a scale | Standard Error 2.27 |
| Phendimetrazine Dose Escalation | Peak Score on Sedative Subscale of the Adjective Rating Scale | 80 mg Cocaine with 70 mg Phendimetrazine | 4.2 units on a scale | Standard Error 2.06 |
| Phendimetrazine Dose Escalation | Peak Score on Sedative Subscale of the Adjective Rating Scale | 0 mg Cocaine with 140 mg Phendimetrazine | 2.1 units on a scale | Standard Error 1.22 |
| Phendimetrazine Dose Escalation | Peak Score on Sedative Subscale of the Adjective Rating Scale | 10 mg Cocaine with 140 mg Phendimetrazine | 2.7 units on a scale | Standard Error 1.56 |
| Phendimetrazine Dose Escalation | Peak Score on Sedative Subscale of the Adjective Rating Scale | 20 mg Cocaine with 140 mg Phendimetrazine | 3.1 units on a scale | Standard Error 1.62 |
| Phendimetrazine Dose Escalation | Peak Score on Sedative Subscale of the Adjective Rating Scale | 40 mg Cocaine with 140 mg Phendimetrazine | 2.8 units on a scale | Standard Error 1.52 |
| Phendimetrazine Dose Escalation | Peak Score on Sedative Subscale of the Adjective Rating Scale | 80 mg Cocaine with 140 mg Phendimetrazine | 4.0 units on a scale | Standard Error 2.19 |
| Phendimetrazine Dose Escalation | Peak Score on Sedative Subscale of the Adjective Rating Scale | 0 mg Cocaine with 210 mg Phendimetrazine | 1.8 units on a scale | Standard Error 0.57 |
| Phendimetrazine Dose Escalation | Peak Score on Sedative Subscale of the Adjective Rating Scale | 10 mg Cocaine with 210 mg Phendimetrazine | 2.6 units on a scale | Standard Error 0.9 |
| Phendimetrazine Dose Escalation | Peak Score on Sedative Subscale of the Adjective Rating Scale | 20 mg Cocaine with 210 mg Phendimetrazine | 3.8 units on a scale | Standard Error 1.4 |
| Phendimetrazine Dose Escalation | Peak Score on Sedative Subscale of the Adjective Rating Scale | 40 mg Cocaine with 210 mg Phendimetrazine | 4.2 units on a scale | Standard Error 1.68 |
| Phendimetrazine Dose Escalation | Peak Score on Sedative Subscale of the Adjective Rating Scale | 80 mg Cocaine with 210 mg Phendimetrazine | 4.7 units on a scale | Standard Error 2.26 |
Secondary
Peak Score on Stimulant Subscale of the Adjective Rating Scale
Subjects completed 16 items that loaded into the Stimulant Subscale of the Adjective Rating Scale. The items were rated 0-4 on a Likert-type scale and the sum for the 16 stimulant items was summed to yield the Stimulant Subscale score. The maximum score for this scale was 64, the minimum was 0. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.
Time frame: This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Phendimetrazine Dose Escalation | Peak Score on Stimulant Subscale of the Adjective Rating Scale | 0 mg Cocaine with 0 mg Phendimetrazine | 5.2 units on a scale | Standard Error 1.05 |
| Phendimetrazine Dose Escalation | Peak Score on Stimulant Subscale of the Adjective Rating Scale | 10 mg Cocaine with 0 mg Phendimetrazine | 5.5 units on a scale | Standard Error 1.33 |
| Phendimetrazine Dose Escalation | Peak Score on Stimulant Subscale of the Adjective Rating Scale | 20 mg Cocaine with 0 mg Phendimetrazine | 6.3 units on a scale | Standard Error 1.52 |
| Phendimetrazine Dose Escalation | Peak Score on Stimulant Subscale of the Adjective Rating Scale | 40 mg Cocaine with 0 mg Phendimetrazine | 6.6 units on a scale | Standard Error 1.64 |
| Phendimetrazine Dose Escalation | Peak Score on Stimulant Subscale of the Adjective Rating Scale | 80 mg Cocaine with 0 mg Phendimetrazine | 8.1 units on a scale | Standard Error 1.47 |
| Phendimetrazine Dose Escalation | Peak Score on Stimulant Subscale of the Adjective Rating Scale | 0 mg Cocaine with 70 mg Phendimetrazine | 4.4 units on a scale | Standard Error 0.97 |
| Phendimetrazine Dose Escalation | Peak Score on Stimulant Subscale of the Adjective Rating Scale | 10 mg Cocaine with 70 mg Phendimetrazine | 5.2 units on a scale | Standard Error 0.92 |
| Phendimetrazine Dose Escalation | Peak Score on Stimulant Subscale of the Adjective Rating Scale | 20 mg Cocaine with 70 mg Phendimetrazine | 6.3 units on a scale | Standard Error 1.17 |
| Phendimetrazine Dose Escalation | Peak Score on Stimulant Subscale of the Adjective Rating Scale | 40 mg Cocaine with 70 mg Phendimetrazine | 6.2 units on a scale | Standard Error 0.9 |
| Phendimetrazine Dose Escalation | Peak Score on Stimulant Subscale of the Adjective Rating Scale | 80 mg Cocaine with 70 mg Phendimetrazine | 7.3 units on a scale | Standard Error 1.26 |
| Phendimetrazine Dose Escalation | Peak Score on Stimulant Subscale of the Adjective Rating Scale | 0 mg Cocaine with 140 mg Phendimetrazine | 3.7 units on a scale | Standard Error 1.1 |
| Phendimetrazine Dose Escalation | Peak Score on Stimulant Subscale of the Adjective Rating Scale | 10 mg Cocaine with 140 mg Phendimetrazine | 5.3 units on a scale | Standard Error 0.91 |
| Phendimetrazine Dose Escalation | Peak Score on Stimulant Subscale of the Adjective Rating Scale | 20 mg Cocaine with 140 mg Phendimetrazine | 5.8 units on a scale | Standard Error 1.18 |
| Phendimetrazine Dose Escalation | Peak Score on Stimulant Subscale of the Adjective Rating Scale | 40 mg Cocaine with 140 mg Phendimetrazine | 7.8 units on a scale | Standard Error 1.54 |
| Phendimetrazine Dose Escalation | Peak Score on Stimulant Subscale of the Adjective Rating Scale | 80 mg Cocaine with 140 mg Phendimetrazine | 8.1 units on a scale | Standard Error 1.43 |
| Phendimetrazine Dose Escalation | Peak Score on Stimulant Subscale of the Adjective Rating Scale | 0 mg Cocaine with 210 mg Phendimetrazine | 4.7 units on a scale | Standard Error 1.08 |
| Phendimetrazine Dose Escalation | Peak Score on Stimulant Subscale of the Adjective Rating Scale | 10 mg Cocaine with 210 mg Phendimetrazine | 5.2 units on a scale | Standard Error 1.14 |
| Phendimetrazine Dose Escalation | Peak Score on Stimulant Subscale of the Adjective Rating Scale | 20 mg Cocaine with 210 mg Phendimetrazine | 7.4 units on a scale | Standard Error 1.38 |
| Phendimetrazine Dose Escalation | Peak Score on Stimulant Subscale of the Adjective Rating Scale | 40 mg Cocaine with 210 mg Phendimetrazine | 7.3 units on a scale | Standard Error 1.35 |
| Phendimetrazine Dose Escalation | Peak Score on Stimulant Subscale of the Adjective Rating Scale | 80 mg Cocaine with 210 mg Phendimetrazine | 9 units on a scale | Standard Error 1.23 |