Acute Respiratory Distress Syndrome, Atelectasis, Emphysema, Hyperinflation, Pleural Effusion, Pneumothorax, Pulmonary Contusion, Pulmonary Edema
Conditions
Keywords
Electrical impedance tomography, lung imaging
Brief summary
The goal of this study is to evaluate the sensitivity and specificity of Electrical Impedance Tomography (EIT) as a bedside diagnostic tool for lung pathologies in patients who are mechanically ventilated. In electrical impedance tomography low amplitude, low frequency current is applied on electrodes, and the resulting voltage is measured and used to computed the electrical properties of the interior of the chest as they change in time. The computed properties are used to form an image, which can then be used for monitoring and diagnosis.
Detailed description
The goal of this study is to characterize the ability of the electrical impedance tomography system (hardware and software) to distinguish between lung pathologies by assessing the sensitivity and specificity as well as the overall agreement with the CT scan in terms of spatial resolution. The study will test, as well as refine, the mathematical algorithms needed to create meaningful outputs on adult patients receiving mechanical ventilation and who also have received or will be receiving a CT scan as part of their standard of care.
Interventions
DEVICEMechanical Ventilation
Subjects will receive mechanical ventilation as part of their standard of care, as specified in the enrollment criteria
DEVICECT Scan
Subjects will receive a CT scan as part of their standard of care, as specified in the enrollment criteria
Sponsors
National Institute for Biomedical Imaging and Bioengineering (NIBIB)
Colorado State University
Study design
Observational model
CASE_ONLY
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients admitted to the ICU at Medical Center of the Rockies and on mechanical ventilation * Age greater than or equal to 18 * Computed Tomography of the chest during normal course of hospital admission
Exclusion criteria
* Age \<18 * Any skin disorder that would prevent placement of the electrodes on the chest wall * Hemodynamic instability prohibiting patient from being moved to place the device
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Sensitivity and specificity for diagnosing lung pathology | One year | The sensitivity and specificity of EIT for the detection and identification of different types of lung pathology will be assessed with clinical diagnosis aided by CT scan as the gold standard. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Regional correlation with CT scan | One year | The spatial correlation between the organs and lung pathology in the CT scan image in the plane of the electrodes and the EIT image will be computed. |
Countries
United States
Outcome results
None listed