COPD
Conditions
Brief summary
Preliminary data show that in COPD patients, HFT substantially decreases ventilatory demand during sleep. The central hypothesis of this proposal is that lowering ventilatory demand using nasal high-flow therapy during sleep will elevate lung function, reduce dyspnea on exertion and improve quality of life. Thus, this proposal aims will determine the effects HFT over time on 1) lung function; 2) dyspnea on exertion; and 3) quality of life.
Interventions
DEVICENasal High Flow
Sponsors
Johns Hopkins University
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 100 Years
Healthy volunteers
No
Inclusion criteria
* 1\. Consenting adults over the age of 18 with COPD
Exclusion criteria
* 1\. Apnea Hypopnea Index\>15 events/hr 2. Use of Non-invasive positive pressure ventilation (CPAP + Bilevel) 3. Severe bilateral nasal obstruction (apparent mouth breathing at rest) 4. Documented clinical cardiovascular disease, as defined below: 1. myocardial infarction in past 3 months 2. revascularization procedure in past 3 months 3. implanted cardiac pacemaker or ICD 4. unstable arrhythmias 5. congestive heart failure with ejection fraction \< 40% 6. uncontrolled hypertension (BP \> 190/110) 5. History of end stage renal disease (on dialysis) 6. History of end stage liver disease, such as: <!-- --> 1. Jaundice 2. ascites 3. history of recurrent gastrointestinal bleeding 4. transjugular intrahepatic portosystemic shunt (TIPS) ; 7. Transportation industry worker (commercial truck or bus drivers, airline pilots) 8. Known pregnancy (by self report) 9. Known coagulopathy or anticoagulant use (e.g. coumadin) other than aspirin. 10. Do you take medications for any of the following reasons: <!-- --> 1. Pain control (besides NSAIDs) 2. Sleep medication 3. Benzodiazepines 4. Methadone
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Lung Function | Baseline and 1 month | Spirometry will be performed before and after each sleep study |
| Dyspnea score | Baseline and 1 month | Borg scale score before and after each sleep study |
| Sleep quality | Baseline and 1 month | Sleep architecture assessed from sleep studies |
| Quality of life | Baseline and 1 month | St Georges Respiratory Questionnaire Hopkins Sleep Survey MRC Breathlessness Scale UCSD Shortness of Breath |
Countries
United States
Outcome results
None listed