Traumatic Brain Injury
Conditions
Keywords
Traumatic brain injury, Neuroglobin, Nogo-A, Prognosis
Brief summary
Neuroglobin has been described as a marker of traumatic brain injury. Nogo-A plays an important role in mediating neuroanatomical plasticity and functional recovery following traumatic brain injury. The investigators sought to examine the changes in serum neuroglobin and Nogo-A concentrations in patients with traumatic brain injury during the initial 96-h posttraumatic period and assessed the relation of neuroglobin and Nogo-A to Glasgow Coma Score and prognosis of such patients with traumatic brain injury.
Interventions
None listed
Sponsors
Shanghai 6th People's Hospital
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Patients who suffered head trauma and whose highest abbreviated injury score (AIS) was 3 or less (other than head injury) * Patients who delivered to hospital within 4 h
Exclusion criteria
* Patients who suffered open injuries * Patients who had existing prior neurological disease * Patients whose serial serum samples could not be obtained * Patients less than 18 years of age * Patients who suffered severe life-threatening injury to organs other than the brain
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Glasgow Outcome Scale scores | 6 months | Glasgow Outcome Scale 1 = death; Glasgow Outcome Scale 2 = vegetative state; Glasgow Outcome Scale 3 = severe neurological deficit; Glasgow Outcome Scale 4 = mild neurological deficit and Glasgow Outcome Scale 5 = premorbid level of functioning or completely recovery. Unfavorable outcome was defined as a Glasgow Outcome Scale score of ≤ 3, and favorable outcome was defined as a Glasgow Outcome Scale score of \> 3. |
Countries
China
Outcome results
None listed