Phenotypic Heterogeneity in Hemophilia A: An Investigation of the Role of Platelet Function

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02225483

Enrollment

Registered

2014-08-26

Start date

2014-09-30

Completion date

2016-12-31

Last updated

2017-02-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hemophilia A

Brief summary

The is study will examine whether variation in clinical bleeding frequency and severity among boys with severe Hemophilia A (Factor VIII deficiency) is associated with variations in laboratory measurements of platelet activity.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

MALE

Age

3 Years to 20 Years

Healthy volunteers

Inclusion criteria

* documented circulating FVIII level of ≤1% * age 3 - 20 years * may be on primary or secondary prophylaxis * granting of informed consent

Exclusion criteria

* measurable inhibitor level at the time of enrollment * ingestion of aspirin/supplement known to influence platelet function within 14 days of blood sampling, or ibuprofen within 3 days

Design outcomes

Primary

Measure	Time frame	Description
Procoagulant platelet-derived microparticle formation	At time of enrollment	—
Platelet aggregation	At time of enrollment	Whole blood platelet aggregation responses

Countries

Canada

Outcome results