Tumor, Benign, Optic Nerve
Conditions
Keywords
Perioptic, Stereotactic, Radiation, Benign brain tumor, Optic apparatus
Brief summary
The purpose of this study is to find out what effects (good and bad) CyberKnife stereotactic radiosurgery has on tumors near the critical structures of the eye (optic apparatus). The investigators hypothesize that hypofractionated stereotactic radiotherapy via the CyberKnife ® can deliver tumor ablating doses of radiation to perioptic lesions safely and effectively while sparing the adjacent optic apparatus and normal brain tissues from receiving damaging doses of radiation.
Detailed description
The CyberKnife system is a type of radiation machine that uses a special system to precisely focus large doses of x-rays (radiation) on the tumor. The device is designed to concentrate large doses of radiation onto the tumor so that injury from radiation to the nearby normal tissue will be minimal.
Interventions
RADIATIONCyberKnife Radiosurgery
25 Gy delivered in 5 fractions of 5 Gy per fraction
Sponsors
Community Cancer Center, Normal, Illinois
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
21 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Perioptic lesion within 2mm of the optic apparatus * Age \>= 21 * KPS \>= 50 * Planning Target Volume (PTV) \<= 6.0 cm in maximal diameter
Exclusion criteria
* Malignant histology * Age \< 21 * KPS \<= 40 * Planning Target Volume (PTV) \> 6.0 cm in maximal diameter * Prior whole brain XRT * Gross total resection
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Tumor status | 5 years | To determine the local control rate of patients with perioptic lesions treated with stereotactic CyberKnife radiosurgery. |
Countries
United States
Outcome results
None listed