Jaundice
Conditions
Brief summary
It is just an observation study. The investigates want to explore the signal changes of resting state functional Magnetic resonance Imaging (fMRI) after light treatment in jaundice infants. Signal changes contain blood oxygenation level dependent (BOLD) and arterial spin labeling (ASL).Indicator of BOLD is amplitude of low-frequency fluctuation（ALFF).Indicator of ASL is cerebral blood flow (CBF). The investigates assume that the children with jaundice after light therapy, ALFF and CBF will change. Focus on the globus pallidus and subthalamic nuclei. The two brain regions were proved to be abnormal in MRI T1, T2 structure signal in kernicterus. Doctors observe the status of infants aside.Using monitoring probe can see clearly.
Detailed description
resting state fMRI scan light therapy the second time resting state fMRI scan
Interventions
DEVICElight treatment
clinical routine treatment according to the doctor's advice
Sponsors
Hangzhou Normal University
Study design
Observational model
CASE_CROSSOVER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
1 Days to 28 Days
Healthy volunteers
No
Inclusion criteria
* hyperbilirubinemia
Exclusion criteria
* asphyxia * cerebral dysgenesis
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| amplitude of low-frequency fluctuation change before and after light treatment | before and after light treatment | It is indicator of blood oxygenation level dependent. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| cerebral blood flow change before after light treatment | before and after light treatment | It is indicator of arterial spin labeling. |
Countries
China
Contacts
Primary ContactXiao-Bao Xue
Outcome results
None listed