The Effect of Exercise Training on Cardiac Structure and Function

Status

Completed

Phases

Phase 1Phase 2

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02224495

Enrollment

200

Registered

2014-08-25

Start date

2011-09-30

Completion date

2013-05-31

Last updated

2014-08-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Myocardial Infarction

Brief summary

Exercise training, as part of cardiac rehabilitation, is effective in improving functional capacity and quality of life in patients with coronary artery disease. Other cardiovascular and non-cardiovascular benefits have been reported, namely in glucose metabolism, skeletal muscle function, oxidative stress, vascular function, pulmonary circulation, ischaemia-reperfusion lesion and ventricular remodelling. However, the benefit of exercise training on systolic and diastolic function is controversial especially after acute myocardial infarction where no longitudinal study has evaluated diastolic function using modern echocardiographic parameters. The hypothesis is that a structured program of exercise training can improve systolic and diastolic function in patients after myocardial infarction.

Interventions

BEHAVIORALStructured exercise training

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Investigator)

Eligibility

Sex/Gender

ALL

Age

18 Years to 75 Years

Healthy volunteers

Inclusion criteria

* Patients one month after myocardial infarction * Older 18 years

Exclusion criteria

* Age above 75 years, * Inability to exercise, * Hemodinamically significant valvular disease, * Moderate to severe chronic lung disease (vital capacity and/or forced expiratory volume in 1 s \<80% of age-dependent predicted value), * Atrial fibrillation * Exercise induced myocardial ischemia * Anaemia (haemoglobin \<12 g/dl).

Design outcomes

Primary

Measure	Time frame	Description
Myocardial early diastolic velocity at mitral annulus by tissue Doppler (E' velocity)	4 months	Determined by echocardiography; results in cm/s

Secondary

Measure	Time frame	Description
Ratio between early diastolic filling velocity from mitral inflow and myocardial early diastolic velocity at mitral annulus by tissue Doppler (E/E' ratio)	4 months	Determined by echocardiography; no unit (ratio)
Myocardial systolic velocity at mitral annulus by tissue Doppler (S' velocity)	4 months	Determined by echocardiography; results in cm/s
Left ventriclular ejection fraction	4 months	Determined by echocardiography; results in %

Countries

Portugal

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 18, 2026