Prediction of Fluid Responsiveness in Atrial Fibrillation Patients Who Underwent Valvular Heart Surgery: Peep-induced Increase in Central Venous Pressure vs. Passive Leg Raising

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02224378

Enrollment

Registered

2014-08-25

Start date

2012-03-31

Completion date

2014-10-31

Last updated

2015-04-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Valvular Heart Surgery

Keywords

fluid responsiveness, atrial fibrillation, passive leg raising, central venous pressure, valvular heart surgery

Brief summary

Dynamic indices of preload depending on the heart-lung interaction require sinus rhythm and cannot be applied to patients with atrial fibrillation. PEEP-induced increase in central venous pressure (CVP) was shown to be a valid predictor of fluid responsiveness after cardiac surgery in patients with sinus rhythm, and was speculated to be of value in patients with rhythm other than sinus. The aim of this study is to assess the predictability of PEEP-induced increase in CVP and passive leg raising (PLR)-induced changes in stroke volume index (SVI) on fluid responsiveness in patients with atrial fibrillation following valvular heart surgery.

Interventions

PROCEDUREpeep induced CVP

PROCEDUREpassive leg raising(PLR)

Study design

Allocation

NON_RANDOMIZED

Intervention model

PARALLEL

Primary purpose

DIAGNOSTIC

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

20 Years to No maximum

Healthy volunteers

Inclusion criteria

1. age ≥20 2. atrial fibrillation patients who underwent elective valvular heart surgery

Exclusion criteria

1. age \< 20 2. LV ejection fraction \< 40% 3. any pulmonary disease 4. end stage renal disease 5. high intrabdominal pressure patient 6. contraindication of passive leg raising 7. deep vein thrombosis

Design outcomes

Primary

Measure	Time frame	Description
fluid responsiveness	1hr after arriving at ICU	1. ventilator peep setting was adjusted to 0cmH2O as baseline 2. Then peep was increased to 10cmH2O for 5 min. 3. We set peep to baseline 0cmH2O again, making patients to semirecumbent position following passive leg raising at 30 degree for 5 min. 4. After that, 300 ml of hydroxyethyl starch 130/0.4 was infused in the supine position for 10-20 min and haemodynamic variables including SVI were assessed 5 min after completion of fluid challenge.

Countries

South Korea

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026