Respiratory Failure
Conditions
Keywords
Patients, mechanical, ventilation, tracheostomy
Brief summary
Ventilator-associated pneumonia (VAP) is a serious complication and carries increased risks of morbidity and mortality for patients who require mechanical ventilation. VAP is associated with the contamination and colonization of bacteria in the lower airway. These bacteria may be present in the lower airway by the aspiration of oropharyngeal secretions. Therefore limiting the amount of secretions that pass the glottis and enter the airway is paramount. Patients who require prolonged mechanical ventilation may have a tracheostomy tube placed to manage breathing. These tubes may have a distal cuff which sits within the trachea. When the cuff is inflated, oropharyngeal secretions will pool above the cuff of the tracheostomy tube thereby limiting the amount of secretions entering the lower airway. These secretions may leak around the cuff and cause tracheobronchial colonization. It has been shown that removal of secretions that pool above the cuff via dorsal lumen suction leads to a decreased incidence of VAP. The purpose of this study is to measure the effect of suction above the cuff tracheostomy tubes related to VAP incidence
Interventions
Sponsors
Study design
Eligibility
Inclusion criteria
* Patients on mechanical ventilation for respiratory failure for at least 72 hours. * A score of 35 to 65 on the Simplified Acute Physiology Score II (SAPS II). * Does not have a pulmonary infection estimated by a Clinical Pulmonary Infection Score (CPIS). * Age \>= 18 years. * have no
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of VAP | at 28 days |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Mortality rate | at 28 days | Mortality at 28-day (all-cause mortality) starting from enrollment (at tracheostomy time) |
| Duration of mechanical ventilation | 30 days | — |
| ICU length of stay | 30 days | — |
| Ventilator free days after tracheostomy | 28 days | — |
Countries
Italy