Pilot Study: Combining Nutritional Supplements With Standard Antidepressant to Treat Depression.

A Randomized Double-Blind Placebo-Controlled Pilot Study of L-tyrosine and L-tryptophan in Depressed Patients Receiving L-methylfolate and and SSRI

Status

Withdrawn

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02223299

Enrollment

Registered

2014-08-22

Start date

2015-11-30

Completion date

2015-11-30

Last updated

2020-02-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Depression

Keywords

Depression, SSRI, Nutritional Supplements, Beck Depression Scale

Brief summary

\*\*This study never received IRB approval and no participants were ever enrolled\*\* The purpose of this study is to determine if adding over the counter nutritional supplements will have a benefit to participants currently taking prescribed antidepressants who have not experienced complete remission of their depression symptoms.

Detailed description

Inclusion Criteria: Detroit VA Patients with major depression, mild to moderate treated with an SSRI and not having complete remission of symptoms as defined by feeling their normal selves Randomized into two groups: Experimental: will receive month supply of deplin 15mg, L-tyrosine 6g/d into 2 divided doses, and L-tryptophan 2g/d into 2 divided doses. Control: will receive month supply of deplin 15mg , and 2 placebo pills. Beck Depression Scale (BDI-2) to be administered at baseline and every 2 weeks for 1 month.

Interventions

DIETARY_SUPPLEMENTL-tyrosine

6g/d daily for 30 days

DIETARY_SUPPLEMENTL-Tryptophan

2g/d daily for 30 days

DRUGdeplin

15mg daily for 30 days

OTHERPlacebo A

a sugar-pill that looks like a real medication

OTHERPlacebo B

a sugar-pill that looks like a real medication

Study design

Allocation

RANDOMIZED

Intervention model

SINGLE_GROUP

Primary purpose

OTHER

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Inclusion criteria

\*\*This study never received IRB approval and no participants were enrolled\*\* Inclusion Criteria: * Veterans Administration Medical Center patients with major depression, mild to moderate treated with an SSRI and not having complete remission of symptoms.

Design outcomes

Primary

Measure	Time frame	Description
Benefit of nutritional supplement	30 days	Through participant interviews and Beck Depression scale determine if adding nutritional supplements improve or resolve complete remission of depression symptoms.

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026