Biomarkers in Saliva in Children With Juvenil Idiopathic Arthritis

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02223195

Enrollment

Registered

2014-08-22

Start date

2015-03-31

Completion date

2019-10-31

Last updated

2020-08-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Juvenile Idiopathic Arthritis

Keywords

Juvenile Idiopathic Arthritis, Saliva

Brief summary

Purpose and aims This as a pilot study that aims to investigate which inflammatory biomarkers can be found in saliva in children with Juvenile Idiopathic Arthritis (JIA). The hypothesis is that children with JIA will show a different pattern of inflammatory biomarkers in saliva than healthy Children. The null hypothesis is that there are no differences.

Detailed description

This is a comparison between 100 children with JIA and 100 healthy children. Saliva will be collected and analyzed with respect to biomarkers. One-hundred consecutive patients with active JIA, as diagnosed by the Department of Pediatric Rheumatology, Astrid Lindgrens Barnsjukhus, Karolinska University Hospital will be included. Inclusion criteria are: * age between 7 and 14 years * a diagnosis of JIA according to the International League of Associations for rheumatology Exclusion criteria are: * current malignancies * TMJ surgery or trauma within two years * recent intra-articular glucocorticoid injection in TMJ (within 1 month) * other conditions or diseases than JIA that may cause orofacial pain. The parents of the patients and/or the patients will give their verbal and written informed consent to participate in the study according to the permission from the regional ethical committee 2011/2:1. The control group of 100 age and sex matched healthy children will be included at Folktandvården Stockholms Län AB. Inclusion criteria are: • age between 7 and 14 years Exclusion criteria are: * current malignancies * TMJ surgery or trauma within two years * recent intra-articular glucocorticoid injection in TMJ (within 1 month) * A diagnosis of JIA * other conditions or diseases than JIA that may cause orofacial pain. The parents of the patients and/or the patients will give their verbal and written informed consent to participate in the study according to the permission from the regional ethical committee 2011/2:1.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

7 Years to 14 Years

Healthy volunteers

Inclusion criteria

1\. A diagnosis of JIA according to the International League of Associations for rheumatology (ILAR) The parents of the patients and/or the patients will give their verbal and written informed consent to participate in the study according to the permission from the regional ethical committee 2011/2:1

Exclusion criteria

1. current malignancies 2. TMJ surgery or trauma within two years 3. Recent intra-articular glucocorticoid injection in TMJ (within 1 month) 4. Other conditions or diseases than JIA that may cause orofacial pain. Fore the controllgroup JIA are excluded

Design outcomes

Primary

Measure	Time frame	Description
Biomarkers in saliva, a comparison between healthy children and children with juvenile idiopathic arthritis.	one day	Saliva sampels will be colleceted and analysed

Countries

Sweden

Outcome results