Human Intervention Study of Egg Protein Derivative on Cardiovascular Risk

Dietary Intervention Study to Assess the Effects of Albumin-Derived Peptides on Cardio-Metabolic Risk Factors in Adults

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02223169

Acronym

CardiProtein

Enrollment

Registered

2014-08-22

Start date

2014-04-30

Completion date

2016-02-29

Last updated

2017-05-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypertension

Keywords

Blood Pressure, Hypertension, Cardiovascular disease

Brief summary

Heart disease and stroke are the most common cause of death in Ireland today.One of the main risk factors for heart disease and stroke is high blood pressure or hypertension. Research has found that certain specific proteins or peptides found in foods such as dairy, meat, fish and eggs may promote heart health reducing blood pressure in adults with hypertension. The aim of this study is to investigate the potential beneficial effects egg peptides may have on heart health, in particular, effects on blood pressure.

Detailed description

Poor dietary habits of Irish adults has been accompanied by epidemics of obesity and metabolic disorders such as type II diabetes leading to a substantial predicted increase in the prevalence of chronic diseases such as cardiovascular disease.Hypertension is a major contributing factor to the development of cardiovascular and metabolic diseases. Dietary factors play a significant role in the prevention and/or treatment of hypertension and therefore the development of foods with antihypertensive properties could prove beneficial.

Interventions

DIETARY_SUPPLEMENTEgg albumin-derived peptide

Double-blind intervention study cross-over design with one sachet containing 3g Egg albumin-derived peptide (Tensio-control) or placebo (maltodextrin) in Phase one followed by cross-over in Phase 2.

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

PREVENTION

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

50 Years to 65 Years

Healthy volunteers

Yes

Inclusion criteria

* Male and female * Non-diabetic * Aged 50-65 * BMI 25-35kg/m² * Mild hypertensive: Blood pressure 130-149 mmHg

Exclusion criteria

* Current smoker * Diagnosed hypertensive * History of cardiovascular disease * Diabetic * Chronic kidney disease * Gastrointestinal disease * Currently on anti-hypertensive medications * Allergic to eggs

Design outcomes

Primary

Measure	Time frame
A change between baseline blood pressure and endpoint blood pressure within the intervention group vs control group.	42 days

Countries

Ireland

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026