Infections, Neurodegenerative Diseases
Conditions
Brief summary
In this trial, concentrations of transition metals of interest are quantified in surplus cerebrospinal fluid (CSF) and blood serum samples. Quantification of the transition metals will be performed by inductively coupled plasma mass spectrometry (ICP-MS). The treating physicians as well as the patients will not be informed about the results of drug concentrations.
Detailed description
Samples used include: Remaining portions of samples collected for diagnostic or therapeutic reasons (paired CSF and blood serum samples). No lumbar puncture will be done specifically for this protocol. The objective of this study is to gain an overview about transition metals concentrations in blood serum and CSF in order to provide preliminary data on patients. The effect of neurodegenerative diseases on metals or the other way round will be assessed if possible.
Interventions
None listed
Sponsors
University of Cologne
Study design
Observational model
ECOLOGIC_OR_COMMUNITY
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
• * The trial will include any patient (with various diseases, especially neurodegenerative diseases) who received a lumbar puncture.
Exclusion criteria
* • The lower age limit is 18 years. In concordance with the objective of the project there is no specific
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Transition metal concentration | 5 years |
Countries
Germany
Contacts
Primary ContactUwe Fuhr, Professor
Outcome results
None listed