Disorder of Aging
Conditions
Keywords
Elderly, vitamin D insufficiency, High dose vitamin D3 supplementation, Polymorphism of the VDR gene
Brief summary
A vitamin D3 high dose would act as an antioxidant and anti-inflammatory improving markers of oxidative stress and inflammation in the elderly. Seniors exhibiting polymorphism in the VDR gene would become non-responsive to supplementation.
Detailed description
The high prevalence of hypovitaminosis D in the elderly can be identified as a risk factor for developing cardiovascular disease and consequent increase in oxidative stress and chronic inflammation. Polymorphisms in the gene that encodes the vitamin D receptor (VDR) can influence the cellular responses supplementation of vitamin D. The study objective is to evaluate the influence of supplementation of 200,000 in a single high dose of vitamin D3 in the inflammatory status and oxidative stress elderly and the influence of polymorphism of the VDR gene in this response. One randomized, placebo-controlled clinical trial, designed with non-institutionalized elderly in northeastern Brazil will be held. All volunteers will sign the Instrument of Consent and will undergo clinical, nutritional, anthropometric and biochemical evaluation. The purpose is to produce new knowledge helping to unravel the beneficial effects of vitamin D3.
Interventions
DIETARY_SUPPLEMENTVitamin D3
High dose of 200,000 IU of cholecalciferol orally in a single dose
DIETARY_SUPPLEMENTPlacebo
Capsules of starch, no therapeutic action
Sponsors
Federal University of Paraíba
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
FEMALE
Age
60 Years to 90 Years
Healthy volunteers
Yes
Inclusion criteria
* Aged 60 years; diagnosis of failure / vitamin D, preserved cognitive status, disability accepting participate and are not included in any of the
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| number of elderly women with sufficient vitamin D levels | four weeks after the intervention |
Secondary
| Measure | Time frame |
|---|---|
| number of elderly who have reduced serum levels of High-Sensitivity C-Reactive Protein | four weeks after the intervention |
| number of elderly who have reduced serum levels of Alpha 1 Acid Glycoprotein | four weeks after the intervention |
| number of elderly who have reduced plasma levels of malondialdehyde (MDA) | four weeks after the intervention |
| number of elderly that increased plasma antioxidant full capacity | four weeks after the intervention |
Other
| Measure | Time frame |
|---|---|
| Number of Participants with Polymorphism of the VDR gene | Participants will be followed for the duration of recruitment , an expected average of 1 week |
Countries
Brazil
Contacts
Primary ContactIsa Gabriela M Cavalcante, DDS
Outcome results
None listed