Pain
Conditions
Keywords
statins, nondepolarizing muscle relaxants, rocuronium, myalgia
Brief summary
provide evidence for prevention or reduction muscle pain.
Detailed description
The purpose of this study is to determine interaction of statins and nondepolarizing muscle relaxant,In order to provide evidence for prevention or reduction muscle pain.
Interventions
DRUGRocuronium
Rocuronium 0.6mg/kg iv single dose
Sponsors
Huang-wei LV
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
40 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Patients with American Society of Anesthesiologists physical status I-III * Patients taking statins for at least 3 months and those who had never used statins were considered to be eligible
Exclusion criteria
* Orthopedic * Spinal surgery * Surgery involving extensive muscle manipulation * History of liver and kidney failure * Neuromuscular disease * Susceptibility to or family history of malignant hyperthermia * Extensive denervation of skeletal muscle * Chronic pain syndromes * Taking medications that might interact with the effect of rocuronium or serum myoglobin difficult intubation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| plasma myoglobin concentration | 20 minutes after administration |
Secondary
| Measure | Time frame |
|---|---|
| urine myoglobin and onset plus duration of succinylcholine block | 2 and 24 hours postoperatively |
| serum potassium concentration | 2 and 24 hours postoperatively |
| plasma creatine phosphokinase concentration | 2 and 24 hours postoperatively |
| muscle pain | 2 and 24 hours postoperatively |
Countries
China
Outcome results
None listed