Volatile Versus Propofol Anesthesia in OPCAB

Comparison of Propofol and Isoflurane Anesthesia on Cardioprotection and Clinical Outcomes in Patients Undergoing Off-pump Coronary Artery Bypass Graft Surgery : A Propensity-score Analysis

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02222142

Enrollment

1080

Registered

2014-08-21

Start date

2010-01-31

Completion date

2012-12-31

Last updated

2014-08-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Off Pump Coronary Artery Bypass Graft

Keywords

Ischemic heart disease, Off pump coronary artery bypass graft, Isoflurane, Propofol

Brief summary

Off pump coronary artery bypass graft (OPCAB) still requires myocardial protection owing to intermittent regional ischemic episode. The investigators retrospectively evaluated the cardioprotective and clinical outcomes of propofol versus isoflurane anesthesia in patients undergoing OPCAB.

Detailed description

Several experimental and clinical researches have suggested that volatile anesthetics may reduce mortality in cardiac surgery owing to its preconditioning induced cardioprotective effect. Off-pump coronary artery bypass graft (OPCAB) surgery still requires cardioprotective strategies due to coronary hypoperfusion during anastomosis. The aim of this study was to evaluate the possible cardioprotective effect and clinical outcomes of propofol versus isoflurane anesthesia in patients undergoing OPCAB using propensity matching.

Interventions

DRUGIsoflurane

Comparison between isoflurane and propofol, Retrospective study

Study design

Observational model

CASE_CONTROL

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

20 Years to No maximum

Healthy volunteers

Inclusion criteria

* OPCAB

Exclusion criteria

* On pump conversion

Design outcomes

Primary

Measure	Time frame	Description
CK-MB, CRP	Change from preoperative value in CK-MR and CRP at Postoperative day(POD), POD 1 and 2	Comparison of CK-MB and CRP values between propofol and isoflurane groups on postoperative day, POD1 and POD 2

Secondary

Measure	Time frame	Description
Clinical adverse outcomes	until 1 year after OPCAB	clinical adverse outcomes until postoperative 1 year

Other

Measure	Time frame	Description
Cardioprotection and clinical adverse outcomes in diabetic patients	POD, POD 1, POD 2, one month, one year	primary and secondary outcome analysis in diabetic patients

Countries

South Korea

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026