Healthy
Conditions
Keywords
Vitamin D, 25(OH)D, Aerobic training, Near-infrared spectroscopy, Diffuse correlation spectroscopy, MRS
Brief summary
The purpose of this study is to identify the magnitude of muscle lipid redistribution and muscle oxygen use in individuals 60 years old or older following combined treatment of vitamin D repletion and aerobic training compared to vitamin D repletion alone, aerobic training alone, or no treatment.
Detailed description
The investigators plan to recruit approximately 56 aged individuals with vitamin D insufficiency for a 13 week trial. All subjects will be 60 years of age or older. Participants will be randomized to one of four groups: vitamin D (50,000IU/wk) + aerobic training (7 days during the 13th week); vitamin D (50,000IU/wk) + normal daily activity during the 13th week; placebo + aerobic training (7 days during the 13th week); or placebo + normal daily activity during the 13th week. Following screening and informed consent process a physical activity questionnaire will be administered. A blood draw will then be conducted at baseline, midpoint and endpoint. Collected blood for the purposes of this study will assess vitamin D status (25(OH)D), parathyroid hormone, ionized calcium, insulin, and a comprehensive metabolic panel. At baseline and endpoint muscle lipid will be assessed using Magnetic Resonance Spectroscopy and muscle oxygen consumption will be determined using a novel hybrid diffuse optical instrument consisting of a near-infrared spectroscopy and a diffuse correlation spectroscopy. In addition, at each study time point 3 dietary recalls will be completed and physical activity will be measured using an accelerometer.
Interventions
DIETARY_SUPPLEMENTvitamin D
50,000IU/wk of vitamin D3
OTHERaerobic training
7 days of treadmill training during the 13th week of study
Sponsors
David Travis Thomas
Study design
Allocation
RANDOMIZED
Intervention model
FACTORIAL
Primary purpose
OTHER
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
60 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Age: 60 and older * BMI: 18.5-29 * Communicates fluently in English
Exclusion criteria
* Metal implant not suitable for MRI * Any form of hormone replacement therapy * Engage in more than 1 hr/week of vigorous activity * Participated in a high-intensity resistance or aerobic training program in the last 3 months * Lower extremity injury or surgery in the past 3 months * Foot sores or bone conditions severely limiting ability to move or perform exercise or joint pain made worse by mild exercise * Diabetes, inflammatory bowel disease, renal disease or uncontrolled hypertension. * Currently have or had a history of cardiovascular or pulmonary disease that would preclude the involvement in the performance of exercise * History of myopathy (including congenital myopathies) * History of neurological conditions related to spinal derangement, disk disease, peripheral neuropathies, tremor and rigidity * Past medical history of hyperparathyroidism, kidney stones or rhabdomyolysis * Currently receiving treatment for vitamin D deficiency * Vitamin D level \>30ng/mL * Currently smoking
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| blood measure | Change from Baseline in vitamin D at 13 weeks | vitamin D |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| muscle lipid | baseline and 13 weeks after baseline | Intramyocellular lipid and extramyocellular lipid will be assessed using magnetic resonance spectroscopy and fat segmentation. |
| muscle oxygen consumption | baseline and 13 weeks after baseline | Local muscle tissue oxidative capacity will be measured using a novel hybrid diffuse optical instrument consisting of a near-infrared spectroscopy (NIRS) and a diffuse correlation spectroscopy (DCS) |
Countries
United States
Outcome results
None listed