Obsessive-Compulsive Disorder
Conditions
Keywords
OCD, Functional Magnetic Resonance Imaging (fMRI)
Brief summary
The purpose of this study is to examine the brain functioning of OCD patients and healthy controls before and after treatment with Exposure and Response Prevention (EXRP) therapy.
Detailed description
The capacity to coordinate thoughts and actions to execute goal-directed behaviors (cognitive control) and the capacity to anticipate, respond to, and learn from reward (reward processing) are key processes for human behavior. Dysfunction in these processes has been hypothesized to contribute to repetitive thoughts and behaviors in many disorders, including obsessive-compulsive disorder (OCD), Tourette Syndrome (TS), and eating disorders. We will use multimodal imaging to investigate neural circuits that support cognitive control and reward processing, using OCD as a model system. The short-term goal is to clarify how circuit-based abnormalities contribute to repetitive thoughts/behaviors; these data will inform future transdiagnostic studies. The long-term goal is to identify control and reward circuit-abnormalities as targets for new transdiagnostic treatments.
Interventions
BEHAVIORALExposure & Response Prevention (EX/RP)
Exposure and Response Prevention (EX/RP) is a type of Cognitive Behavioral Treatment for treating OCD.
Sponsors
New York State Psychiatric Institute
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 55 Years
Healthy volunteers
Yes
Inclusion criteria
for Patients: * Male and females with OCD aged 18-55 * Diagnostic and Statistical Manual of Mental Disorders (DSM-5) Diagnosis of OCD * Not on psychotropic medication
Exclusion criteria
for Patients: * Presence of metallic devices or dental braces in the body that are contraindicators for MR imaging * Comorbid psychiatric conditions that significantly elevate the risk of study participation (e.g. psychotic disorders, bipolar disorder, evidence of dementia or other cognitive disorder, suicidality) * Unstable medical conditions that need attention and would make participation in the study unsafe (e.g. very high blood pressure) * Use of psychotropic medication * Females who are pregnant or post-menopausal Inclusion Criteria for Healthy Volunteers \- Male and females aged 18-55
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change from baseline in brain activation (fMRI) and fractional anisotropy (Diffusion tensor imaging) after therapy | Baseline & approximately 10 weeks later |
Secondary
| Measure | Time frame |
|---|---|
| Change in reaction times and correct responses on Stop signal reaction time task | Baseline and approximately 10 weeks later, at second scan |
Countries
United States
Outcome results
None listed