Renal Failure
Conditions
Brief summary
A study conducted in the laboratory revealed the existence of a window during which patients with renal failure appreciate the protein-rich foods. This period, located immediately after the dialysis, is likely related to the purification of plasma products resulting from protein catabolism. It therefore appears necessary to understand the mechanisms that may explain these changes by measurements of ghrelin (orexigenic hormone), leptin (anorectic hormone) and plasma amino acids.
Detailed description
In 24 patients with renal failure treated by hemodialysis, it is evaluated (at 8:00 am and at 11:00 am), a day without hemodialysis and another day after the hemodialysis: * Hunger sensation, * Olfactory liking assessed separately for 6 foods (2 carbohydrate-, 2 fat- and 2 protein-rich foods) and 2 non-alimentary products, * Food wanting evaluated by the sequential presentation of 18 images of food (6 fat-, 6 carbohydrate- and 6 protein-rich foods), * Two blood samples for the assays of leptin, ghrelin, creatinine, albumin and pre-albumin as well as plasma amino acids. 24 healthy subjects are also evaluated in order to compare the results from patients to those of control subjects.
Interventions
None listed
Sponsors
University of Burgundy
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* Patients and healthy subjects were included if they were aged between 18 and 80 years
Exclusion criteria
* diabetes, advanced undernutrition (BMI \< 17.5 kg m-2, prealbumin \< 250 mg.L-1), congestive heart failure, acute or chronic infection, ongoing antibiotic treatment, active cancer, liver cirrhosis, smoking (more than 5 cigarettes/day), alcohol consumption (more than 3 units/day), aversion to the foods eaten or smelt during the study, impaired comprehension of the cognitive tasks
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Amount of wanting for protein-rich foods | 20 min (from 8:00 to 8:20 am) and 20 min (from 11:00 to 11:20 am) | The wanting is determined after the successive presentation (for ten seconds) of 18 pictures of food. For each food the question is at the present time, do you want to eat this food? . For each photo, subjects place a vertical line on a 10 cm horizontal line bounded at its ends by no desire and extremely envy (visual analog scale).The wanting for proteins is the mean score for the desire to eat protein-rich foods. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Concentrations of the plasma amino-acids | 8:30 am and 11:30 am | Variation in concentrations of amino-acids during the morning a day with hemodialysis and a day without hemodialysis, and comparison with plasma AAs from healthy subjects |
Countries
France
Outcome results
None listed