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Evaluation of Different Analysis Methods for Circulating Tumor Cells, Circulating Endothelial Cell, and Circulating Tumor DNA in Patient Followed for a Tumoral Pathology

Evaluation of Different Analysis Methods for Circulating Tumor Cells, Circulating Endothelial Cell, and Circulating Tumor DNA in Patient Followed for a Tumoral Pathology

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT02220556
Acronym
CTC-CEC-ADN
Enrollment
360
Registered
2014-08-20
Start date
2010-12-31
Completion date
2018-06-30
Last updated
2025-08-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Solid Tumor, Adult

Brief summary

Fifteen cohorts will be opened. Each cohort will explore one analysis method and/or tumoral type. Up to 50 patient can be included into each cohort.

Interventions

PROCEDUREBlood sampling

Sponsors

Institut Curie
Lead SponsorOTHER

Study design

Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* 18 years old or more * Performance status from 0 to 4 * Patient treated followed for histologically confirmed solid tumor type of any of these localization : breast, prostate, uterus, ovary, colon, lung, head and neck, melanoma. * Informed consent form signed.

Exclusion criteria

* Patient with history of other invasive cancer within 5 years. * Patient treated for any non-invasive cancer * Patient individually deprived of liberty or placed under the authority of a tutor * Geographical condition potentially preventing compliance with the study protocol.

Design outcomes

Primary

MeasureTime frameDescription
CTC, CEC or ctDNA incidence3 yearsnumber of CTC or CEC in 7.5ml of blood

Secondary

MeasureTime frameDescription
CTC and CEC molecular characterization3 yearsThis outcome is self-explanatory.
Circulating tumor DNA (ctDNA) detection and quantification3 yearsplasma mutation detection (number of copy)

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 21, 2026