Ketamine Prevent POCD

Low Dose Ketamine Prevent the Postoperative Cognitive Dysfunction in Aged Patients Underwent Orthopaedic Surgery，a Randomized Control Double Blinded Multicenter Clinical Trail

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02220400

Acronym

KPPOCD

Enrollment

484

Registered

2014-08-19

Start date

2014-09-30

Completion date

2016-09-30

Last updated

2014-08-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Knee Osteoarthritis, Necrosis of Femoral Head

Keywords

Postoperative cognitive dysfunction, Ketamine, Surgery

Brief summary

Previous study demonstrated that neuroinflammation induced by surgery is the main cause of the postoperative cognitive dysfunction. As an agonist of NMDA receptor, ketamine is proved to be an anti-inflammation agent. In present study investigators hypothesized that low dose ketamine would prevent the cognition decline after orthopedic surgery in aged patients.

Interventions

DRUGKetamine

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

60 Years to No maximum

Healthy volunteers

Inclusion criteria

* Elder than 60 * Easily communicated with Chinese * Selected to kneel or hip replacement * Agree to take part into this clinical trail

Exclusion criteria

* Existing cerebral disease， or have a history of neurological and psychiatric disease including AD, stroke and psychosis * Existing cognitive impairment as evidenced by Mini-Mental State Examination scores below 24 * Several audition or vision disorder * Preoperative systolic Blood pressure over 190mmHg or diastolic pressure \>100mmHg * Existing a history of hyperthyroidism * Patient with glaucoma * Unwillingness to comply with the protocol or procedures

Design outcomes

Primary

Measure	Time frame	Description
Short-term cognitive changes after surgery	The day before surgery and 7 days after surgery (or before leave hospital)	Investigators would use mini-mental state examination(MMSE), Visual reproduction test,digit symbol，digit span,color trail test and Stroop color and word test for measuring the short-term cognitive changes of patients after surgery.
Long-term cognitive changes after surgery	The day before surgery and 2 months after surgery	Investigators would use mini-mental state examination(MMSE), Visual reproduction test,digit symbol，digit span,color trail test and Stroop color and word test for measuring the long-term cognitive changes of patients after surgery.

Countries

China

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026