Exercise Improve Sympathetic Modulation in Chronic Heart Failure Patients

Exercise Training Improves Oscillatory Pattern and Arterial Baroreflex Control of Sympathetic Nerve Activity in Patients With Chronic Heart Failure

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02219451

Enrollment

Registered

2014-08-19

Start date

2013-08-31

Completion date

2014-07-31

Last updated

2014-08-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Heart Failure

Keywords

Chronic heart failure, exercise training, Sympathetic modulation, arterial baroreflex control

Brief summary

The purpose of this study is to verify the effects of exercise training on sympathetic modulation and arterial baroreflex control in patients with chronic heart failure.

Detailed description

Retrospective study. Patients were recruited by database from Rehabilitation Unit of Cardiovascular Rehabilitation and Exercise Physiology of the Heart Institute (InCor). The aim of this study is to assess the effects of exercise training on sympathetic modulation and arterial baroreflex control in patients with chronic heart failure. The investigators studied twenty-six chronic heart failure outpatients, age 30 to 70 years, functional class II to III of New York Heart Association, left ventricular ejection fraction (LVEF) ≤40% and peak oxygen uptake (VO2) ≤20. The exclusion criteria were recent myocardial infarction or unstable angina (\<3 months), heart failure duration (\<3 months), permanent pacemaker dependence, atrial fibrillation, skeletal muscle abnormality (e.g., arthritis) and participation in a regular exercise program. They were assigned to 2 groups: Untrained (n=13) and trained (n=13).

Interventions

OTHERexercise training

exercise training

Study design

Allocation

Intervention model

SINGLE_GROUP

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

30 Years to 70 Years

Healthy volunteers

Inclusion criteria

* Patients with chronic heart failure * Age 30 to 70 years * Functional class II to III of New York Heart Association * Left ventricular ejection fraction (LVEF) ≤40% * Peak oxygen uptake (VO2) ≤20

Exclusion criteria

* Recent myocardial infarction or unstable angina (\<3 months) * heart failure duration (\<3 months) * Permanent pacemaker dependence * Atrial fibrillation * Skeletal muscle abnormality (e.g., arthritis) * Participation in a regular exercise program

Design outcomes

Primary

Measure	Time frame	Description
Autonomic control	4 months	To asses the effects of exercise training on sympathetic modulation by analyze of autonomic control in chronic heart failure patients after 4 months protocol.Time series of muscle sympathetic nerve activity and systolic arterial pressure were analyzed by autoregressive spectral analysis

Secondary

Measure	Time frame	Description
Arterial baroreflex control	4 months	To asses the effects of exercise training on arterial baroreflex by analyze of arterial baroreflex control in chronic heart failure patients after 4 months. The arterial baroreflex control was analyzed by bivariate autoregressive.

Countries

Brazil

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026