Gene Expression Analysis of the Endometrium After Endometrial Biopsy in Fertile Women

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02219425

Enrollment

Registered

2014-08-18

Start date

2014-06-30

Completion date

2016-08-31

Last updated

2017-01-31

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infertility

Keywords

Infertility, Endometrium, Endometrial biopsy, Gene expression

Brief summary

The aim of this study is to evaluate the gene expression of the endometrium after an endometrial biopsy in fertile women using Next Generation Sequencing of total RNA.

Detailed description

An endometrial biopsy is done at cycle day LH+7 and repeated in the next cycle at cycle day LH+7. Tissue is analysed and compared for changes in gene expression profile using Seq RNA

Interventions

PROCEDUREendometrial biopsy

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 40 Years

Healthy volunteers

Yes

Inclusion criteria

* Fertile women * Age: 18-40 years * BMI: 18-32 * Regular menstrual cycle * No use of hormonal contraceptives or IUD the last 3 months

Exclusion criteria

* Patients in need of a interpreter * Suspected intrauterine abnormalities * Pregnancy

Design outcomes

Primary

Measure	Time frame	Description
Gene Expression of the Endometrium after an endometrial biopsy	1 month between each biopsy	An endometrial biopsy is done at cycle day LH+7 and repeated in the next cycle at cycle day LH+7. Endometrial tissue is analysed for changes in gene expression profile of various chemokines and cytokines using RNA Sequencing technology

Countries

Denmark

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026