Pregnancy
Conditions
Keywords
Pregnancy, DHA, Gestational Length, Cognitive Development
Brief summary
Supplementation with DHA during pregnancy will increase gestational length and improve cognitive development.
Detailed description
This was a trial of supplementation with DHA during pregnancy to increase gestational length. Subjects were provided with 300 mg, 600 mg or placebo (olive oil) in a randomized design from week 24-26 of pregnancy until delivery. Gestational age, birth weight and birth length data were collected and infants growth at 2 and 4 months and cognitive development at 4 months and 1 year were measured.
Interventions
DIETARY_SUPPLEMENT600 mg DHA
Pregnant women were given 600 mg DHA in the last trimester of pregnancy
DIETARY_SUPPLEMENT300 mg DHA
Pregnant women were given 300 mg DHA in the last trimester of pregnancy and through the first 3 months of breastfeeding
DIETARY_SUPPLEMENTPlacebo
Pregnant women in the control group received placebo of either olive oil or high oleic acid sunflower oil during the study period
Sponsors
USDA Beltsville Human Nutrition Research Center
Colorado State University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 40 Years
Healthy volunteers
No
Inclusion criteria
* singleton pregnancy * 18 years of age or older
Exclusion criteria
* cervical incompetence * presence of cervical cerclage * placenta previa * intrauterine infection * known substance abuse * multiple fetuses * current pre-eclampsia * preexisting diabetes
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Gestational Length | 13 weeks | Length of gestation as measured by Last menstrual period method and US |
| Cognitive Development | 4 months | Bayley's Scales of Infant Development measured at 4 months of age |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Infant birth length | 13 weeks | self-explanatory |
| Infant Growth Velocity | 2 months to 4 months of age | Change in infant length and weight from 2 to 4 months of age |
| Infant birth weight | 13 weeks | self-explanatory |
| Infant head circumference at birth | 13 weeks | self-explanatory |
Countries
United States
Outcome results
None listed