Effect of Homogenization and Pasteurization of Milk on the Stomach Problems in Adults

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02219126

Enrollment

Registered

2014-08-18

Start date

2014-08-31

Completion date

2018-01-01

Last updated

2018-01-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Unidentified Stomach Discomfort Following Dairy Consumption

Brief summary

This study aims to investigate differences in digestion rates and stomach problems caused by pasteurized and homogenized milk compared with raw milk in healthy adults by ingestible capsule that measures pH and pressure, diary of symptoms, blood glucose and triacylglycerol levels and plasma cytokine levels.

Interventions

OTHERDietary intervention

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

BASIC_SCIENCE

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Yes

Inclusion criteria

* Homogenized and pasteurized milk causes stomach problems (self-reported) * unhomogenized and unpasteurized milk does not cause stomach problems (self-reported) * age 18-65 * BMI 18,5 - 30 * hemoglobin under normal range * fasting plasma alanine aminotransferase ALAT \< 60 U/l (normal liver function) * fasting plasma thyroid-stimulating hormone (TSH) 0.4 - 4.5 mU/l (normal thyroid function) * fasting plasma creatinine \< 118 umol/l (normal kidney function)

Exclusion criteria

* pace maker * Crohn's disease or other disease of the intestinal tract * intestinal operation within the last 3 months * difficult dysphagia * smoking * constipation

Design outcomes

Primary

Measure	Time frame	Description
Pressure in the intestinal tract	Day 0 - Day 5	Pressure in the intestinal tract as measured by ingestible Smart Pill -capsule.
Gastrointestinal symptoms (self-reported)	Day 0 - Day 5	Gastrointestinal symptoms (self-reported) as measured by a questionnaire. The questionnaire is devided into seven types of stomach discomfort, and also includes a possibility to describe a stomach discomfort outside these seven given alternatives. The severity of the symptoms is self-reported on a three-step scale.

Secondary

Measure	Time frame
Plasma triacylglycerols	20min, 40min, 60min, 120min, 180min, 240min
Plasma glucose	20min, 40min, 60min, 90min, 120min, 180min, 240min
Plasma insulin	20min, 40min, 60min, 90min, 120min, 180min, 240min

Countries

Finland

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026