Chronic Obstructive Pulmonary Disease
Conditions
Keywords
airway resistance, lung compliance, Duration of mechanical ventilation
Brief summary
Investigators developed a test to assess the bronchodilator effects in mechanically ventilated chronic obstructive pulmonary disease patients by comparing the change of airway resistance. No matter whether patients respond to bronchodilator or not, they are randomized assigned to bronchodilator 3-4 times per day group and no bronchodilator group. Then investigators could objectively decide whether individual patients need or benefit from bronchodilator administration.
Detailed description
Bronchodilator is commonly used in mechanical ventilated chronic obstructive pulmonary disease patients. It is assumed that patient's response to bronchodilator is the same during acute exacerbation or when stable whether on mechanical ventilation or not. Decision to treat is often independent of response and the patient's response to the medicine is not precisely evaluated. Investigators developed a test to assess the bronchodilator effects in mechanically ventilated chronic obstructive pulmonary disease patients by comparing the change of airway resistance. No matter whether patients respond to bronchodilator or not, they are randomized assigned to bronchodilator 3-4 times per day group and no bronchodilator group. Then investigators could objectively decide whether individual patients need or benefit from bronchodilator administration.
Interventions
DRUGAlbuterol
Sponsors
First Affiliated Hospital of Chongqing Medical University
Beijing Chao Yang Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
should meet all the criteria: 1. Acute exacerbated chronic obstructive pulmonary disease 2. Invasive mechanical ventilation with intubation outside ICU no more than 48 hours
Exclusion criteria
Meet any of the criteria: 1. Asthma 2. Tracheotomy 3. Prolonged Mechanical Ventilation (Have been mechanical ventilated for more than 21 days) 4. Unstable hemodynamic status 5. Severe pneumonia 6. Contraindication for bronchodilator 7. Contraindication for sedation 8. Refusal to participate in study 9. Re-intubation in 48 hours 10. Mental disorder, could not understand and accomplish pulmonary function test
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Percentage of 12% Decrease in airway resistance | 30 minutes |
Secondary
| Measure | Time frame |
|---|---|
| Duration of mechanical ventilation | participants will be followed for the duration of ICU stay, an expected average of 28 days |
Countries
China
Contacts
Primary ContactJie Li, Master
Outcome results
None listed