Developmental Dyslexia
Conditions
Keywords
Electroencephalography (EEG), Magnetic Resonance Imaging (MRI), Multimodal Neuroimaging, Development, Prediction, Intervention
Brief summary
The long-term goal of this study is to improve prediction of poor reading outcome at preschool age by using a combination of behavioural and neuroimaging measures and to evaluate a specific computerized training program to support children with problems during reading acquisition.
Interventions
OTHERComputerized reading training
Sponsors
University of Zurich
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
5 Years to 9 Years
Healthy volunteers
Yes
Inclusion criteria
for all groups: * Healthy, native (CH-) German speaking subjects, with an estimated non-verbal intelligence quotient (IQ) \>=80, without neurological and/or psychiatric disorder (except for attention deficit hyperactivity disorder, specific learning disorders, developmental language impairments) * Additional criteria for subgroups: * Recruitment of preschoolers (aged 5.5-7.5 years): * Healthy children with increased risk for developmental dyslexia in their second year at kindergarten * Recruitment of children in first grade (aged 6.5-8.5years): * Children showing impairments in learning to read (first/second grade). * Adults (aged 20-40 years): * Healthy, normal reading
Exclusion criteria
for all groups: * MRI contraindications * No history of premature delivery and/or maternal reports of severe prenatal, perinatal or postnatal complications.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes in reading and spelling performance | Participants will be tested at three times for the duration of the cross-sectional intervention, an expected average of 8 months | Performance in normed reading and/or spelling (standardized tests) as a result of reading acquisition and training |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Developmental and training induced changes in functional brain activation and brain structure | Participants will be tested after an expected average of 8, 12 and 16 months | Changes in activation/structure of core language network regions assessed by EEG and MRI during development, learning and training |
| Accuracy of prediction on reading performance outcome | Participants will be tested at T1 and on average 8 months later | Accuracy of prediction on reading performance (standardized tests) using behavioural and/or neuroimaging measures. Neuroimaging measures: EEG and MRI (functional activation, structural measures from white and/or grey matter, temporal information from event-related potential and/or frequency analyses) |
Countries
Switzerland
Contacts
Primary ContactSilvia Brem, PhD
Outcome results
None listed