Healthy
Conditions
Keywords
NAFLD, Oral Fructose Challenge, 31P MRS, Liver, Subjects
Brief summary
The purpose of this study is to determine the effects of an oral fructose challenge on liver adenosine triphosphate (ATP) reserves using 31P magnetic resonance spectroscopy (MRS) as a potential measure measure of liver health.
Detailed description
This study uses 31P spectra acquired from the liver in healthy subjects following a fructose drink to monitor ATP levels. This is also related to baseline BMI, liver glycogen and liver lipid levels
Interventions
DIETARY_SUPPLEMENTFructose
Oral Fructose Challenge (75 g fructose in 500 ml water) following overnight fast
Sponsors
Biotechnology and Biological Sciences Research Council
Unilever R&D
Stephen Bawden
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
18 Years to 30 Years
Healthy volunteers
Yes
Inclusion criteria
* Male * Age 18 - 30 * BMI 20 - 27 kg/m\^2 * Healthy
Exclusion criteria
* Smokers * Liver disease or Metabolic Disorders * Metal implants (not suitable for MRI)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Hepatic ATP reserves following an oral fructose challenge | 2 hours post prandial | Monitor hepatic ATP levels following an oral fructose challenge using 31P magnetic resonance spectroscopy |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Correlate hepatic ATP depletion / recovery with BMI, liver lipids and liver glycogen | 2 hours post prandial | Measure baseline liver lipid and glycogen using magnetic resonance spectroscopy and correlate BMI, lipid and glycogen levels with rate of ATP depletion and recovery following an oral fructose challenge |
Countries
United Kingdom
Outcome results
None listed