High Sensitive Troponin T Release
Conditions
Keywords
Volatile Anesthetic, Cardioprotection, Lung surgery, non cardiac surgery
Brief summary
It has been shown that the use of volatile anaesthetics, that are usually used to perform a general anesthesia, have cardioprotective properties. This has been shown in animal studies and in patients that underwent cardiac surgery. The aim of our study is to examine if Sevoflurane, a volatile anaesthetic, has this properties in patients undergoing lung surgery.
Interventions
DRUGSevoflurane
Anaesthesia is induced (1-2 mg/kg) and maintained (5-7 mg/kg/h) with propofol and remifentanil (1 µg/kg and 0,2-0,4 µg/kg/min). After induction of anesthesia the propofol infusion is stopped and patients receive 1 MAC Sevoflurane over 30 min. Then the propofol infusion is restarted and Sevoflurane is washed out.
DRUGTIVA
Anaesthesia is induced (1-2 mg/kg) and maintained (5-7 mg/kg/h) with propofol and remifentanil (1 µg/kg and 0,2-0,4 µg/kg/min).
Sponsors
Dr. Horst Schmidt Klinik GmbH
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Lung surgery * ASA (American Society of Anesthesiologists) physical status 1-3
Exclusion criteria
* Disposition for malignant hyperthermia * Medication with ß-blocking drugs * Use of clonidin
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Troponin T | change of Troponin T levels preoperative and postoperative up to 40 hours after surgery | assessing a change in high sensitive Troponin T (5th generation) Level before and at six time points after surgery (right after surgery, every 8 hours up to 40 hours after surgery) |
Countries
Germany
Outcome results
None listed