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High Flow Nasal Canula Oxygen Helps Preoxygenate ARDS Patients

Observational Study of High Flow Nasal Canula Oxygen to Preoxygenate ARDS Patients That Require Intubation

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT02214576
Acronym
HIGHER
Enrollment
50
Registered
2014-08-12
Start date
2011-09-30
Completion date
2015-08-31
Last updated
2015-08-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Respiratory Distress Syndrome

Keywords

Respiratory Distress Syndrome, Adult, intubation, intratracheal, Oxygen Inhalation Therapy, Positive-Pressure Respiration, laryngoscopy

Brief summary

Tracheal intubation in the ICU is associated with significant complications and morbidity. Desaturation is among the most frequent and hazardous complication, occurring in almost one out of four intubations, that may in some instances lead to cardiac arrest; despite appropriate preoxygenation. Non-invasive ventilation may help improve preoxygenation but does not allow for apneic oxygenation and may not be performed in patients with neurological impairment. High flow nasal canula oxygen is increasingly used in the ICU in patients with acute hypoxemic respiratory failure and may be used to improve preoxygenation. It is currently used in our ICU for that purpose. Because high flow nasal canula oxygen is our first line oxyten therapy for patients with acute respirtory distress syndrome, we sought to determine its use as a means to ensure preoxygenation in those ARDS patients that require intubation.

Detailed description

High flow nasal canula oxygen is increasingly used to provide heated and humidified oxygen in patients with acute respiratory failure. One of the major advantages of high flow nasal canula oxygen is the possibility to maintain oxygenation during laryngoscopy and thereby providing high flow apneic oxygenation. In addition, and contrary no non-invasive ventilation, preoxygenation may be used in patients with neurological impairment. Finally, the interest of this device is that it is the same that is maintained throughout the whole management of the patient, from ICU admission to intubation.

Interventions

None listed

Sponsors

Hôpital Louis Mourier
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* ARDS according to the Berlin criteria * use of high flow nasal canula oxygen

Exclusion criteria

\-

Design outcomes

Primary

MeasureTime frameDescription
Oxygen saturation30 minutesoxygen saturation measured by pulse oxymetry during intubation and compared to levels before intubation

Secondary

MeasureTime frameDescription
complications60 minutesarrhythmia, hypotension, profound desaturation, cardiac arrest

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026