Fat Perception in the Brain
Conditions
Brief summary
This project will examine neuronal and sensory fat perception. Our hypothesis is that subjects being either hypersensitive or hyposensitive for fat will show different brain activities. Therefore the investigators will conduct functional magnetic resonance imaging (fMRI) and fat detection threshold tests examining neuronal and sensory fat perception.
Interventions
DIETARY_SUPPLEMENTyogurt
Subjects will receive yogurt with varying fat concentrations
Sponsors
University Hospital Tuebingen
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Eligibility
Sex/Gender
ALL
Age
18 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* healthy
Exclusion criteria
* lactose intolerance * fMRI contraindications (metal implants,...)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Fat detection thresholds | each measurement day | A sensory test will be conducted to establish individual fat detection thresholds. It is expected that subjects\* brain activity is dependent on sensory fat sensitivity. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Brain activity | pre and post meal intake | We are interested in brain activations following the consumption of yogurt with either a high or a low fat concentration. To assess this, before as well as after fat intake brain activity will be measured using functional magnetic resonance imaging (fMRI). We expect that brain activity will differ between the high and the low fat yogurt condition. |
Countries
Germany
Outcome results
None listed