Diabetes, Hypertension, Obesity, Sleep Apnea
Conditions
Keywords
Dexmedetomidine, bariatric surgery, postoperative pain, morphine consumption, Quality of recovery
Brief summary
The purpose of this study is to determine if Dexmedetomidine given at the end of surgery will reduce postoperative morphine consumption and improve postoperative quality of recovery as compared to morphine in patients undergoing laparoscopic bariatric surgery.
Detailed description
effect of Dexmedetomidine bolus on postoperative morphine requirements
Interventions
DRUGDexmedetomidine
DRUGMorphine
Sponsors
American University of Beirut Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* Body Mass Index \> 40 kg/m2 or BMI \> 35 kg/m2 with comorbid conditions such as hypertension, diabetes or sleep apnea * American Society of Anesthesiologists class I or II * Undergoing laparoscopic sleeve gastrectomy bariatric surgery
Exclusion criteria
* Allergy to morphine or its derivatives * Allergy to α-2 adrenergic agonists * weight over 180 kg * history of uncontrolled hypertension * heart block greater than first degree * prolonged QT interval * clinically significant neurologic, cardiovascular, renal, hepatic, or gastrointestinal diseases * received an opioid analgesic medication within a 24 h period prior to surgery * history of alcohol, drug abuse or chronic opioid intake * history of psychiatric disorder * pregnant or breastfeeding.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total dose of morphine consumed in Post Anesthesia Care Unit (PACU) | At discharge from the PACU |
Secondary
| Measure | Time frame |
|---|---|
| Numeric Rating Scale (NRS) for Pain | in the PACU and at 24 hours |
| NRS for nausea | in the PACU |
| incidence of pruritus | in the PACU |
| incidence of vomiting or retching | in the PACU |
| Time to first morphine requirement in PACU | in the PACU |
| time to discharge readiness in PACU | in the PACU |
| total morphine consumption at 24 hours | at 24 hours |
| Quality of Recovery (QoR-40) score at 24 hours | at 24 hours |
| overall satisfaction at one month | one month after surgery |
| incidence of respiratory complications | in the PACU |
Countries
Lebanon
Outcome results
None listed