Verticality Perception - Multisensory Contribution

Verticality Perception - Dissociating Head and Trunk Contributors in Healthy Human Subjects

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02212704

Enrollment

Registered

2014-08-08

Start date

2014-10-31

Completion date

2015-11-30

Last updated

2024-11-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Individual Contribution of Different Sensory Systems, Verticality Perception in Healthy Human Subjects

Keywords

vestibular, proprioception, spatial orientation, bayesian

Brief summary

The purpose of this study is to evaluate the relative contribution of head- and trunk-based sensory systems to internal estimates of direction of gravity in healthy human subjects. To implement this assessment experimentally, the investigators will use a motor-driven 3D-turntable and a thermoplastic mask to keep the head in a stable, either roll-tilted (±30°) or aligned with the trunk. The investigators will then obtain measurements of the subjective visual vertical in seven different whole-body roll positions (max. 90° roll-tilt). Analysis will be driven by a state-of-the art Bayesian integration model. The investigators hypothesize that different sensory input signals are combined in a statistically optimal fashion.

Interventions

OTHERVestibular stimulation by use of the turntable (static roll-tilt while the head is roll-tilted relative to the trunk)

OTHER3D-video-head impulse testing

Evaluation of semicircular canal function. This intervention is part of the screening to determine suitability for this study

OTHERVestibular-evoked myogenic potentials (VEMPs)

Evaluation of otolith function. This intervention is part of the screening to determine suitability for this study

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

BASIC_SCIENCE

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 60 Years

Healthy volunteers

Yes

Inclusion criteria

* ages 18-60 years * informed consent * absence of

Design outcomes

Primary

Measure	Time frame
Accuracy and precision of SVV adjustments in different head and trunk roll-tilt positions	During the turntable measurement (90 minutes)

Secondary

Measure	Time frame
relative contribution of head- and trunk-based sensory systems based on Bayesian modelling	while on the turntable (1.5 hours)

Countries

Switzerland

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026