Multiple Sclerosis
Conditions
Keywords
walking, postural balance, falls
Brief summary
The study hypothesis is that for people with moderate to severe multiple sclerosis postural balance and walking improve and the risk of accidental falls are reduced after participating in a specific training intervention of 7 weeks. The hypothesis is also the the effect remain a further 7 weeks post training. Multiple Sclerosis (MS) is disease affecting the central nervous system. Walking and postural balance are often affected early in the course of the disease. The risk of falls is large. Many persons with MS have decreased trunk stability compared to healthy persons . In an earlier study including people with mild to moderate MS we found that a period of core stability exercises reduced the risk of falls. In this study the training concept will be applied for persons with more severe walking limitations.
Interventions
Group balance training 60 minutes 2 times per week plus 3-5 home exercises 2 times/week. Exercises focus om core stability in sitting, standing and lying.
Sponsors
Örebro County Council
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
SINGLE (Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* diagnosed multiple sclerosis * Expanded Disability Scale Score of 5-6.5 * walking speed of less than 0.8 m/s as tested on a 10 meter walking test
Exclusion criteria
* Ongoing relapse * Cognitive or language difficulties that prohibit participating in the intervention or performing the outcome measures * Change in specific MS medication during the last 30 days
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change from baseline in Berg Balance Scale at 8 weeks | baseline, 8 weeks |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change from baseline in Trunk Impairment scale at 8 weeks | baseline, 8 weeks | — |
| Change from baseline in the Trunk Impairment Scale at 15 weeks | baseline, 15 weeks | — |
| Change from baseline in the 10 repetition Si to stand test at 8 weeks | baseline, 8 weeks | — |
| Change from baseline in the Berg Balance scale at 15 weeks | baseline, 15 weeks | — |
| Change from baseline on the Timed Up and Go test at 8 weeks | baseline, 8 weeks | — |
| Change from baseline on the Timed Up and Go test at 15 weeks | baseline, 15 weeks | — |
| Change from baseline on the10 meter walking test at 8 weeks | baseline, 8 weeks | — |
| Change from baseline on the 10 meter walking test at 15 weks | baseline, 15 weeks | — |
| Change from baseline on the 2 minutes walking test at 8 weeks | baseline, 8 weeks | — |
| Change from baseline in 10 repetitions Sit to stand test at 15 weeks | baseline, 15 weeks | — |
| Change from baseline in postural sway at 8 weeks | baseline, 8 weeks | — |
| Change from baseline in postural sway at 15 weeks | baseline, 15 weeks | postural sway in standing on the floor is assessed |
| Change from baseline on the Falls-Efficacy scale at 8 weeks | baseline, 8 weeks | — |
| Change from baseline on the Falls Efficacy scale at 15 weeks | baseline, 15 weeks | — |
| Change from baseline on the Fatigue Scale for Motor and Cognitive functions at 8 weeks | baseline, 8 weeks | — |
| Change from baseline on the Fatigue Scale for Motor and Cognitive functions at 15 weeks | baseline, 15 weeks | — |
| Change from baseline on the MS Walking Scale-12 at 8 weeks | baseline, 8 weeks | — |
| Change from baseline on the MS Walking scale-12 at 15 weeks | baseline, 15 weeks | — |
| The number of falls and accidental falls | from baseline to 15 weeks | the number of falls and accidental falls are noted by the participant in a study-specific falls diary. |
| Change from baseline on the 2 minutes walking test at 15 weeks | baseline, 15 weeks | — |
Countries
Sweden
Outcome results
None listed