Major Depressive Disorder
Conditions
Keywords
Major depression
Brief summary
Depression is a leading cause of disability worldwide, affecting nearly 16% of the general population. Its physiopathology remains unclear. Based on gene-environment studies and epigenetic studies, a main hypothesis proposed that the major depressive episode (MDE) results from the convergence of multiple factors including biological factors such as multi-genic vulnerability, hormonal and immunological variations as well as environmental factors. As a consequence, mRNA could define a biological signature of the MDE.
Interventions
OTHERblood prelevement
blood sample will be done at the inclusion then at T 2 weeks, T8 weeks, T30weeks
OTHERpsychometric data collection
Sponsors
Assistance Publique Hopitaux De Marseille
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* Major depressive disorder at inclusion according to the DSM IV at the time of the inclusion, * Having a score on the scale of depression of Hamilton ( HDRS-17) \> 19 at the time of the inclusion, * Taken care by a grown-up psychiatric department, that the coverage(care) is realized in ambulatory or during a hospitalization
Exclusion criteria
* Schizophrenia
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| describe a transcriptional signature of the Major Depressive Episode. | 6 months | The major aim of our study is to compare the expression level of selected genes between patient suffering from major depression and control subjects and within patients across the MDE evolution. We plan to describe a transcriptional signature of the MDE. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| evaluate the role played by confounding factors as genetic polymorphisms, | 6 months | evaluate the role played by confounding factors as genetic polymorphisms to distinguish bipolar from unipolar depression |
Other
| Measure | Time frame | Description |
|---|---|---|
| evaluate the role played by confounding factors as immune phenotype | 6 months | evaluate the role played by confounding factors as immune phenotype to distinguish bipolar from unipolar depression |
| evaluate the role played by confounding factors as psychotropic medications | 6 months | evaluate the role played by confounding factors as psychotropic medications to distinguish bipolar from unipolar depression |
Countries
France
Outcome results
None listed