Predictability of the Pulse Pressure Variation (PPV) During Spontaneous Ventilation on the Incidence of Hypotension During Induction of Anesthesia

Predictability of the Pulse Pressure Variation During Spontaneous Ventilation on the Incidence of Hypotension During Induction of Anesthesia

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02208570

Enrollment

172

Registered

2014-08-05

Start date

2014-07-31

Completion date

Unknown

Last updated

2016-04-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypotension

Keywords

Hypotension during anesthesia induction

Brief summary

The purpose of this study is to find out the predictability of the pulse pressure variation during spontaneous ventilation on the incidence of hypotension during induction of anesthesia.

Interventions

OTHERPPV>14%

Patients whose preoperative pulse pressure variation during spontaneous ventilation exceed 14

DRUGVolume loading

Hydroxyethyl starch solution 6ml/kg iv injection

OTHERPPV<14%

Patients whose preoperative pulse pressure variation during spontaneous ventilation does not exceed 14

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

TRIPLE (Subject, Caregiver, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

20 Years to 80 Years

Healthy volunteers

Inclusion criteria

* Patients undergoing general anesthesia induction with intravenous anesthesia using propofol and remifentanil * Patients requiring invasive arterial blood pressure monitoring for the surgery

Exclusion criteria

* Refusal of consent * Patients with heart disease (symptomatic valvular heart disease, intracardiac shunt, pulmonary hypertension with pulmonary systolic arterial pressure exceeding 40mmHg) * FEV1 ≤ 50% predicted FEV1 * Patients with chronic renal failure * ASA class IV, V, VI * Systolic arterial blood pressure below 90mmHg before induction of anesthesia

Design outcomes

Primary

Measure	Time frame	Description
Changes of heart rate and systolic arterial blood pressure from baseline values immediately before tracheal intubation	Three minutes after anesthesia agent injection	First, we measure the baseline heart rate and systolic arterial blood pressure and calculate the baseline heart rate and blood pressure. At 3 minutes after anesthesia agent injection we record the heart rate and blood pressure, and perform endotracheal intubation. Then we calculate the percentile change of blood pressure and heart rate from the baseline values.

Secondary

Measure	Time frame	Description
Changes of heart rate and systolic arterial blood pressure from baseline values, three minutes after intubation	Three minutes after endotracheal intubation	We collect the patient's vital signs for 1 second interval during anesthesia induction. We collect the patient's heart rate and blood pressure values for three minutes after endotracheal intubation, and average the numbers. Then we compare the numbers from the baseline value and calculate the changes.
Changes of heart rate and systolic arterial blood pressure from baseline values, three minutes before intubation	Three minutes before endotracheal intubation	We collect the patient's vital signs for 1 second interval during anesthesia induction. We collect the patient's heart rate and blood pressure values for three minutes before endotracheal intubation, and average the numbers. Then we compare the numbers from the baseline value and calculate the changes.

Countries

South Korea

Contacts

Primary ContactJae-Hyon Bahk

bahkjh@snu.ac.kr82-2-2072-2818

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026