Type 1 Diabetes Mellitus
Conditions
Keywords
Type 1 Diabetes Mellitus, Exercise, Appetite
Brief summary
The investigators hypothesise that manipulating the glycaemic index of the meal after exercise will influence the acute appetite responses of Type 1 diabetes individuals
Interventions
DIETARY_SUPPLEMENTMeal composition - Low versus high GI.
Sponsors
Newcastle University
Northumbria University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
18 Years to 50 Years
Healthy volunteers
No
Inclusion criteria
* Aged between 18-50 years old (male or female). * Free from any diabetes related complications (apart from mild background diabetic retinopathy). * HbA1c \<8.5%. * Not taking any prescribed medication other than insulin, and treated with a stable insulin regimen composed of a combination of slow/long acting insulin (glargine or detemir) and fast-acting insulin analogues (lispro or aspart), for a minimum of 6 months before the start of the study. * Demonstrate normal cardiac function in response to exercise.
Exclusion criteria
* Aged younger than 18, or older than 50 years. * Suffering from, or diagnosed with a diabetes related complication (apart from mild background diabetic retinopathy). * HbA1c \>8.5%. * Currently taking prescribed medication, and not currently treated with a stable basal bolus regimen composed of a combination glargine or detemir, and lispro or aspart for at least 6 months before the start of the study. * Failure to demonstrate normal cardiopulmonary responses during exercise, or have a medical condition which could prevent completion of exercise or be exacerbated because of.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Acute subjective appetite responses | 4 hours post-exercise | Subjective appetite ratings via Visual Analogue Scales |
Countries
United Kingdom
Outcome results
None listed