Anesthesia, Leukocyte Function
Conditions
Brief summary
One of the most common side effects of a surgical procedure is infection. In order to lower the number of infections that occur after surgery, it is important for physicians to know how medications used during surgery affect the way the body fights infection. Often, when anesthesiologists are helping people go to sleep before surgery they give people medications known as volatile anesthetics. Volatile anesthetics are medications that can change from a liquid or solid to a gas very easily. Some studies suggest that these types of medications may change the way white blood cells work in the body. Changing the way white blood cells work could possibly increase the person's risk of infection after their surgery or weaken their body's ability to fight infections. The goal of this research study is to learn about how volatile anesthesia medications change the way white blood cells work in people having anesthesia for cardiac procedures. To do this, investigators will examine the function of while blood cells in the laboratory based setting.
Interventions
None listed
Sponsors
Boston Children's Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
12 Months to No maximum
Healthy volunteers
No
Inclusion criteria
* Male and female patients * greater than or equal to 12 months of age * scheduled for a cardiac catheterization, cardiac surgery, or cardiac MRI
Exclusion criteria
* known underlying hematological disorder * known oncological disorder * patients who do not require preoperative laboratory testing
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Leukocyte function under anesthesia | up to 12 months | The study will evaluate ex vivo leukocyte function by testing leukocyte activation, TNF-a production, and phagocytic function in the laboratory. |
Countries
United States
Outcome results
None listed