Coronary Artery Occlusive Disease
Conditions
Keywords
high mobility group box 1, prognostic biomarker, off-pump coronary artery bypass graft, patients
Brief summary
High mobility group 1 (HMGB1) protein is both a nuclear factor and a secreted protein, and has recently been identified as a cytokine mediator of systemic inflammation. HMGB1 is released by inflammatory cells actively, or increased during cell death passively and mediates inflammatory response. It has been reported to have association with the prognosis after acute coronary syndrome, ischemia-reperfusion injury of myocardium, atherosclerosis and heart failure. This study aimed to investigate the relationship of serum levels of HMGB1 and post operative prognosis of patients who had undergone off-pump coronary artery bypass graft.
Interventions
None listed
Sponsors
Yonsei University
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
20 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Age ≥ 20 2. Patients undergoing off-pump coronary artery bypass graft
Exclusion criteria
1. Age \< 20 2. Patients undergoing off-pump coronary artery bypass graft with other simultaneous surgery 3. Patients participating other study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Maximum value of HMGB1 | Change from induction of anesthesia to 2hrs after transfer to intensive care unit | Measure the maximum value of HMGB1 in all patients and calculate median value. And device into upper median value group and under median value group and compare frequency of composite morbidity/mortality rate between two groups. composite morbidity/mortality is as follows: 1. Stroke 2. Renal failure 3. Prolonged ventilation more than 24 hours 4. Deep sternal wound infection 5. Reoperation for any reason 6. Mortality during the hospitalization for surgery, even if over 30 days |
Countries
South Korea
Outcome results
None listed