Relationships Between Macular Pigment Optical Density and Lacquer Cracks in High Myopic Patients.

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02205632

Enrollment

Registered

2014-07-31

Start date

2014-02-01

Completion date

2014-11-01

Last updated

2026-06-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

High Myopia

Brief summary

Lutein ans zeaxanthin, carotenoids provided by dietary intake are mainly located in the macular area. Its absorption peak at 460 nm may reduce photic damages. The macular pigment density can be evaluated by its optical density. Reduced macular pigment level is a significant risk factor for age-macular degeneration. The nutritional intake can minimise the risk of age-macular degeneration.

Interventions

DEVICEMPS II

Study design

Allocation

NON_RANDOMIZED

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Age \>18 years-old * High axial myopia \< -6 dioptries * Presence or not of lacquer cracks in Bruch's membrane in one or both eyes * Patients with social security coverage

Exclusion criteria

* Age \<18 years-old * Amblyopia in the studied eye * Prior ocular surgery * Corneal disease or severe dry eye syndrome * Other retinal disease: diabetic retinopathy, age-related macular degeneration, macular hole, epiretinal membrane central * Extensive chorioretinal atrophy * Allergy to tropicamide * Pregnancy

Design outcomes

Primary

Measure	Time frame
Association between lacquer cracks related to high myopia and the macular pigment optical density	1 day

Secondary

Measure	Time frame
The macular pigment optical density among high myopic patients	1 day

Countries

France

Contacts

PRINCIPAL_INVESTIGATORNicolas LEVEZIEL, MD, PhD

Poitiers University Hospital

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Jun 12, 2026