Diabetes Mellitus Type 2, Diabetic Blood Glucose Monitoring, Dietary Modification, Insulin Tolerance
Conditions
Keywords
Dietary fiber, Dietary Supplements, Type 2 diabetes, Postprandial Period, Plasma insulin, Plasma glucose, Area Under Curve, Soluble fiber
Brief summary
To compare the acute effect of soluble fiber intake from foods or supplement after a common meal on postprandial plasma glucose and insulin in patients with type 2 diabetes. The hypothesis is a meal with a high content of soluble fiber from food determines glycemic and insulinemic response similar to a meal with a high content of soluble fiber from supplement sources.
Detailed description
Three breakfasts (high amount of fiber from diet food sources - HFD, high amount of soluble fiber from guar gum supplement - HFS and usual amount of fiber -UF), isocaloric and similar distribution of carbohydrates, proteins and lipids, the order of breakfasts randomly determined. Meals HFD and HFS have the same amount of fiber from different sources, origin in food and supplement respectively. Meal UF consist of the same foods meal HFS, but without the use of soluble fiber supplement and white bread instead of rye bread (low fiber content in relation to meals HFD and HFS). The supplement (Sachet 5g - Fiber Mais ®: 60% guar gum and 40% inulin) will be added to the plain water to meal HFD.
Interventions
High amount of fiber from diet food sources (HFD; total fiber 9.7g; soluble fiber 5.4g)
High amount of soluble fiber from guar gum supplement (HFS; total fiber 9.1g; soluble fiber 5.4g) - sachet 5 g Fiber Mais, Nestlé Brasil, São Paulo, BR
Usual amount of fiber (UF; total fiber 2.4g; soluble fiber 0.8g)
Sponsors
Study design
Eligibility
Inclusion criteria
* Patients with type 2 diabetes * Body Mass Index (BMI) \<= 35 kg / m² * Hemoglobin A1c (HbA1c) \<= 9%
Exclusion criteria
* Serum creatinine \>2.0 mg/dL * Digestive diseases (e.g. malabsorption) * Severe autonomic neuropathy (presence of symptomatic postural hypotension, gastroparesis, diabetic diarrhea) * Recent cardiovascular event * Cachexia * Psychiatric disorder with impairment of understanding * Participating in other research protocol
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Area Under the Curve (AUC 0-180min) for glycemic and insulinemic responses | Prior to the initial meal A, B and C and 30, 60,120,180 minutes postmeal |
Countries
Brazil