Respiratory Failure, Sepsis, Multiple Organ Dysfunction Syndrome
Conditions
Keywords
Weakness, Mechanical Ventilation, Acupuncture Therapy
Brief summary
Intensive care unit acquired weakness (ICU-AW) is common and dramatically affect recovery. The purpose of this study is to determine whether electric acupuncture therapy is effective in the treatment of ICU-AW especially in the patients receiving mechanical ventilation with sepsis or multiorgan system failure.
Detailed description
The principle of acupuncture is to produce bioelectric current, as a consequence, to invigorate the circulation, promote tissue regeneration, relieve pain, enhance the immune function, etc. And electric acupuncture can stimulate bioelectricity activities at acupoints, out of reach for ordinary acupuncture effect, especially in the fields of nerve/muscle recovery and regeneration.
Interventions
DEVICEelectric acupuncture
Electric acupuncture therapy was made on LI4, LI11, ST36, and ST41 on four limbs for each patient, 30 min for each time, twice per day. Starting from the beginning of mechanical ventilation, to the weaning of the mechanical ventilation.
OTHERconservative
General treatment, without electric acupuncture, include passive range-of-motion exercise，q2H turning，minimizing the use of sedation, etc.
Sponsors
Jiangsu Province Hospital of Traditional Chinese Medicine
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Clinical diagnosis of sepsis or multiple organ dysfunction syndrome * Within 48 hours from the initiation of mechanical ventilation
Exclusion criteria
* Pregnant patients * Neuromuscular disease or cerebrovascular accident * With temporary or permanent pacemaker * Need to use neuromuscular blocking agents * Inactivity for more than 5 days before ICU admission
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| strength related parameters | Participants will be followed until the date of weaning from mechanical ventilation, an expected average of 8 weeks | muscle force, arm circumference, skin fold thickness |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| mechanical ventilation duration | Participants will be followed until the date of weaning from mechanical ventilation, an expected average of 8 weeks | the time span from the beginning of mechanical ventilation, till the weaning of mechanical ventilation |
| 28-day mortality | Participants will be followed until the 28th day after mechanical ventilation | the mortality till the 28th day after mechanical ventilation |
| number of participants with adverse events of electric acupuncture | Participants will be followed until the date of weaning from mechanical ventilation, an expected average of 8 weeks | the adverse enents include fainting, infection, bleeding, viscera damage, and so on. |
| ICU duration | Participants will be followed until the date of discharge from the ICU, an expected average of 8 weeks | the time span from the beginning of mechanical ventilation, till the date of discharge from the ICU |
Countries
China
Outcome results
None listed