Evaluation of Richmond Agitation Sedation Scale According to Alveolar Concentration of Sevoflurane During a Sedation With Sevoflurane in ICU Patients

Status

Completed

Phases

Phase 2

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02202720

Acronym

SEVORASS

Enrollment

Registered

2014-07-29

Start date

2014-08-31

Completion date

2014-11-30

Last updated

2014-11-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Adult Patients, Patients Covered by French Health Care System, Patients Who Have Given Their Consent, Requiring Sedation by Sevoflurane in ICU

Keywords

Sevoflurane, RASS score, Sedation, Minimal alveolar concentration (MAC)

Brief summary

Describe the Richmond Agitation Sedation Scale (RASS) values corresponding to the values of Minimum alveolar concentration of sevoflurane during sedation of patients in ICU

Detailed description

Prospective clinical study in ICU with sedated ventilated patients with sevoflurane using the Mirus® system. Pharmacological study of the concentration-effect relationship by administration at increasing and decreasing concentrations.

Interventions

DRUGSevoflurane

Short term sedation with sevoflurane in ICU

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Requiring sedation by sevoflurane in ICU * Adult patients * Patients covered by french health care system * Patients who have given their consent or his family

Exclusion criteria

* Pregnant or lactating women * Sevoflurane anaphylaxia * Known or suspected risk of malignant hyperthermia * Refusal Protocol * Brain-damaged patients * Hemodynamic conditions not compatible with the use of sevoflurane * ARDS patients * Minor patients

Design outcomes

Primary

Measure	Time frame	Description
Description of the RASS score	at day 1	Describe the RASS score corresponding to the values of sevoflurane MAC during sedation of patients in ICU : RASS score determined at the middle of each level of 30 minutes, each level correspond to determined sevoflurane MAC with ascending MAC ranging from 0 to 0.8 and then descending MAC from 0.8 to 0.

Secondary

Measure	Time frame	Description
determination of the associated hemodynamic and respiratory parameters	at day 1	Determine the associated hemodynamic and respiratory parameters, bispectral index and analgesia-nociception index for each level of sevoflurane MAC (monitored at the middle of each level of 30 minutes).

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026