Change in Cognitive Function and Fatigue During Extended Performance of the Cognitive Demand Battery (CDB) at 1, 3 and 6 Hours Post Consumption, Change in Long Term Declarative Memory at 1, 3 and 6 Hours Post-intervention.
Conditions
Brief summary
Acute, randomized, placebo controlled, double blind, 4 arm crossover study to determine the effect of different combinations of plant based extracts on cognitive function and cerebral blood flow.
Detailed description
The objectives of this study are to assess the effects of oral consumption of three differing combinations of plant based extracts, on cognitive function and cerebral blood flow (using Near infrared Spectroscopy) in comparison to placebo. The primary outcome will be change in cognitive function and mental fatigue during extended performance of the Cognitive Demand Battery (CDB) at 1, 3 and 6 hours post- consumption.
Interventions
OTHERBeverage containing plant based extracts
Intervention involves single exposure, oral consumption of test article following baseline measurements
Sponsors
PepsiCo Global R&D
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 49 Years
Healthy volunteers
Yes
Inclusion criteria
* Are over 18 or under 49 years of age * Self-report of good health * Are not excluded on the basis of the following
Exclusion criteria
* English is first language (some of the cognitive tests have only been validated in native English speakers)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in cognitive function and fatigue during extended performance of the Cognitive Demand Battery (CDB) at 1, 3 and 6 hours post consumption Change in long term declarative memory at 1, 3 and 6 hours post-intervention. | 1-6 hours post intervention |
Secondary
| Measure | Time frame |
|---|---|
| Change in executive function at 1, 3 and 6 hours post intervention. | 1-6 hours post intervention |
| Change in cerebral blood flow parameters (oxygenated and deoxygenated haemoglobin levels and their sum) in the frontal cortex during task performance commencing at 1, 3 and 6 hours post-intervention. | 1-6 hours post intervention |
| Change in episodic memory, as measured by immediate word recall, at 1, 3 and 6 hours post intervention. | 1-6 hours post intervention |
| Change in mood ratings, at 1,3 and 6 hours post intervention. | 1-6 hours post intervention |
Countries
United Kingdom
Contacts
Primary ContactDavid Kennedy, PhD
Backup ContactPhilippa Jackson
Outcome results
None listed